Innate Immunology

Front 1

Pathogen Associated Molecular Patterns
(PAMPs)

Back 1

Repetitive structural patterns found on microbes or their products
ex. Bacterial cell wall components, Viral DNA and RNA

Front 2

Pattern Recognition Molecules (PRMs)

Back 2

Either fixed to leukocyte membranes or are soluble molecules

Front 3

Pattern Recognition Receptors (PRRs)

Back 3

PRMs that are fixed to leukocyte membranes

ex. Toll-like receptor, Scavenger receptors, NK receptors

Front 4

Toll-like Receptors (TLRs)

Back 4

A pattern recognition receptor that has an immune response of phagocytosis, cell lysis and inflammation

Front 5

Mannose binding lectin (MBL)

Back 5

The collectin, protein that flows freely in the blood, that starts the complement cascade

Front 6

Classical C3 convertase (C4b2a)

Back 6

An antigen-antibody complex that cleaves C3 into C3a and C3b

Front 7

Alternative C3 convertase (C3bBb)

Back 7

Binds with properdin to stabilize the molecule and cleave the C3 into C3a and C3b

Front 8

Membrane Attack Complex (MAC)

Back 8

Causes lysis of the pathogen

Front 9

Opsonization

Back 9

Binding or coating of a microbe by antibody or complement which promotes phagocytosis by phagocytes

Front 10

Anaphylatoxins

Back 10

C3a, C4a, C5a

Induce dramatic events that resemble anaphylaxis, a severe systemic allergic reaction

Front 11

Acute Phase Reactants (CRP)

Back 11

Produced in the liver

C-reactive protein (CRP) induce inflammation by activating the complement cascade

Front 12

Heparine and Histamine

Back 12

Released from Mast cells and Basophils

Acts as:

Anti-coagulant

Increases vascular permeability

Neutrophil Chemotaxis, from activated macrophages, monos, lymphs, and endothelial cells

Front 13

Cytokines and Chemokines

Back 13

White Blood Cell chemotaxis

Front 14

Extravasation

Back 14

The way that professional phagocytes get to the injured tissue

Rolling, Sniffing and Stopping, And Migration

Neutrophils Slows and rolls

Neutrophil binds to ICAM via Integrin & rolling stops

Neutrophil exits the blood, into the tissue

Front 15

Integrin and ICAM

Back 15

Integrin: Transmembrane protein involved in the adhesion of cells to each other and to their substrate

ICAM:

Front 16

Selectin-Selectin Ligand (SLIG)

Back 16

NO IDEA

Front 17

Endocytic Pathway

Back 17

1. Early Endosome- Mildly acidic pH

2. Late Endosome- Initiates digestion

3. Endolysosome- Low pH

4. Exocytosis- Expelled from cell

Front 18

Phagosome and phagolysosome

Back 18

Phagosome: Intracellular vesicle in which a captured entity is first sequestered during phagocytosis

Phagolysosome: Vesicle formed by fusion of a phagosome with a lysosome during phagocytosis

Front 19

Granzyme and perforin

Back 19

Perforin: Mechanism of apoptotic target cell destruction triggered when CTLs or NK cells degranulate to release granzymes