Immunology (Test 1) Practice Test 2

Front 1

1. All of the following are true with respect to IgM antibodies EXCEPT which one:

A. they fix complement

B. they occur on the surface of B-cells

C. they predominate in the primary response to antigen

D. they are glycoproteins

E. they mediate allergic reactions

Back 1

E

Front 2

2. TCRs or antibodies react with antigens

A. because both are made by lymphocytes

B. because of complementary fit of both with antigen

C. because both have light and heavy chain polypeptides

D. because both cause histamine release from mast cells

E. because both release porforin

Back 2

B

Front 3

3. All of the following are true of antigen EXCEPT which of the following:

A. They possess epitopes

B. They will react with antibodies

C. They contain antigenic determinants

D. They can elicit an immune response

E. They possess paratopes

Back 3

E

Front 4

4. Which of the following Igs is present normally in plasma at the highest concentration?

A. IgG

B. IgE

C. IgM

D. IgD

E. IgE

Back 4

A

Front 5

5. True or False: The major Ig family to which a particular Ig belongs can be determined by sequential analysis of the 110 amino acids beginning from the carboxy terminus of the heavy chain.

Back 5

TRUE

Front 6

6. True or False: The Ig J-chain is associated with only multimeric forms of IgM and IgA.

Back 6

TRUE

Front 7

. Individuals unable to make the J-protein found in IgA would be expected to have frequent infections of the:

A. Brain

B. Blood

C. Pancreas

D. Intestinal tract

E. all of the above

Back 7

D

Front 8

The class of an Ig is detemined by :

A. the variable region

B. the J-chain

C. the heavy chain

D. the carbohydrate

Back 8

C

Front 9

Fc receptors:

A. occur on the cell surface of cells of the immune system

B. recognize the variable region domains of the Ig heavy chain

C. recognize the constant region domains of the Ig heavy chain

D. recognize the constant region domains of the Ig light chain

E. A and C are correct

Back 9

E

Front 10

10. Killer T-cells effect their killing by:

A. antibodies with specific paratopes

B. by opsonizing the Ag

C. by Class II MHC proteins

D. by inserting a pore forming protein called perforin into the target cell membrane

Back 10

D

Front 11

11. Similarities between an antigen and an immunogen include:

A. Each is sufficient to induce an immune response

B. Each is a target of an immune response

C. Each can be recongnized by antibodies

D. A and B

E. B and C

Back 11

D

Front 12

12. True or False: bcl-2 play an inhibitory role in apoptosis.

Back 12

TRUE

Front 13

13. Dendritic cells are found everywhere in the body EXCEPT:

A. the brain

B. the liver

C. bone marrow

D. the pancreas

E. none of the above are correct

Back 13

A

Front 14

14. Which of the following statements is False about apoptosis?

A. Apoptosis leads to inflammation.

B. An apoptotic cells developes a blebbing appearance around the plasma membrane.

C. Apoptosis controls the life span of progenitor cells.

D. the fas gene initiates/induces apoptosis

Back 14

A

Front 15

15. NKT cells have been shown to play a role in:

A. autoimmune disease

B. graft rejection

C. tumors

D. all of the above

E. A and C

Back 15

D

Front 16

16. True orFalse: Tissue specific macrophages of the liver are called mesangial cells.

Back 16

FALSE

Front 17

17. Which of the following is the most abundant granulocyte:

A. mast cells

B. neutrophils

C. eosinophils

D. basophils

E. erythrocytes

Back 17

B

Front 18

18. True or False: All chemoattractants are chemokines.

Back 18

FALSE

Front 19

19. Which of the following is an important first line of defense against viruses?

A. NK cells

B. B-lymphocytes

C. T-lymphocytes

D. dendritic cells

E. endothelial cells

Back 19

A

Front 20

20. True or False: The most active immunogens tend to be large macromolecules.

Back 20

TRUE