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20 Cards in this Set

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1. All of the following are true with respect to IgM antibodies EXCEPT which one:

A. they fix complement

B. they occur on the surface of B-cells

C. they predominate in the primary response to antigen

D. they are glycoproteins

E. they mediate allergic reactions
E
2. TCRs or antibodies react with antigens

A. because both are made by lymphocytes

B. because of complementary fit of both with antigen

C. because both have light and heavy chain polypeptides

D. because both cause histamine release from mast cells

E. because both release porforin
B
3. All of the following are true of antigen EXCEPT which of the following:

A. They possess epitopes

B. They will react with antibodies

C. They contain antigenic determinants

D. They can elicit an immune response

E. They possess paratopes
E
4. Which of the following Igs is present normally in plasma at the highest concentration?

A. IgG

B. IgE

C. IgM

D. IgD

E. IgE
A
5. True or False: The major Ig family to which a particular Ig belongs can be determined by sequential analysis of the 110 amino acids beginning from the carboxy terminus of the heavy chain.
TRUE
6. True or False: The Ig J-chain is associated with only multimeric forms of IgM and IgA.
TRUE
. Individuals unable to make the J-protein found in IgA would be expected to have frequent infections of the:

A. Brain

B. Blood

C. Pancreas

D. Intestinal tract

E. all of the above
D
The class of an Ig is detemined by :

A. the variable region

B. the J-chain

C. the heavy chain

D. the carbohydrate
C
Fc receptors:

A. occur on the cell surface of cells of the immune system

B. recognize the variable region domains of the Ig heavy chain

C. recognize the constant region domains of the Ig heavy chain

D. recognize the constant region domains of the Ig light chain

E. A and C are correct
E
10. Killer T-cells effect their killing by:

A. antibodies with specific paratopes

B. by opsonizing the Ag

C. by Class II MHC proteins

D. by inserting a pore forming protein called perforin into the target cell membrane
D
11. Similarities between an antigen and an immunogen include:

A. Each is sufficient to induce an immune response

B. Each is a target of an immune response

C. Each can be recongnized by antibodies

D. A and B

E. B and C
D
12. True or False: bcl-2 play an inhibitory role in apoptosis.
TRUE
13. Dendritic cells are found everywhere in the body EXCEPT:

A. the brain

B. the liver

C. bone marrow

D. the pancreas

E. none of the above are correct
A
14. Which of the following statements is False about apoptosis?

A. Apoptosis leads to inflammation.

B. An apoptotic cells developes a blebbing appearance around the plasma membrane.

C. Apoptosis controls the life span of progenitor cells.

D. the fas gene initiates/induces apoptosis
A
15. NKT cells have been shown to play a role in:

A. autoimmune disease

B. graft rejection

C. tumors

D. all of the above

E. A and C
D
16. True orFalse: Tissue specific macrophages of the liver are called mesangial cells.
FALSE
17. Which of the following is the most abundant granulocyte:

A. mast cells

B. neutrophils

C. eosinophils

D. basophils

E. erythrocytes
B
18. True or False: All chemoattractants are chemokines.
FALSE
19. Which of the following is an important first line of defense against viruses?

A. NK cells

B. B-lymphocytes

C. T-lymphocytes

D. dendritic cells

E. endothelial cells
A
20. True or False: The most active immunogens tend to be large macromolecules.
TRUE