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99 Cards in this Set

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True or False: A. MHC co-dominancy means both parental copies of MHC will be expressed in one person, not necessarily on each of his/her cells
False
4. Which of the following is involved in MHC II pathway?
A. beta-2 microglobulin
B. DM
C. Proteosome
D. TAP
DM
Which Ab is most prominent in mucosal immunity?
IgA
3 things that contribute to BCR diversity
Affinity maturation
Combinatorial factor
Junctional Diversity
What process do developing T cells undergo that developing B cells do not?
Positive selection
True or False: Polymorphism of MHC means the population diversity of MHC in one particular MHC locus
True
1. Which of the following cytokines promote Th2 differentiation?
A. IL-1
B. IL-2
C. IL-4
D. IL-6
IL-4
Where does isotype switching take place?
Paracortex

Germinal Center
Where does affinity maturation take place?
Germinal Center
Where does allelic exclusion take place?
Bone marrow

Thymus
2 functions of IgM
BCR

Complement activation
1 function of IgD
BCR
3 functions of IgA
neonatal immunity

mucosal immunity

complement activation
1 function of IgE
ADCC
Classes of Ig that are involved in ADCC
IgG

IgE
Mancini assay
??
Ouchterlony assay
??
Assay to detect cytokine production
Eli-spot
Assay to detect IgA deficiency
immunoelectrophoresis
BCG
??
5. Which Ig found in the serum of a week old newborn would indicate a fetal infection?
IgM
4 diseases strongly associated with MHC I allele
Ankylosing spondilitis
acute anterior uveitis
Reiter syndrome
Reactive arthritis
Ankylosing spondilitis
??
Autoimmune disease more common in men than in women
Reactive arthritis
Celiac disease is which Type of hypersensitivity?
Type IV
Cytopenia is associated with which type of hypersensitivity?
Type II
Most common type of congenital immune deficiency?
B cell
Which is the most common deficiency that leads to typical recurrent infection in sinus and lung specifically?
IgA deficiency
Which SCID is not recommended to be treated with bone marrow transplant?
Omenn
Omenn
??
What is the significant sign indicating immune deficiency?
Patient experiences recurrent infection.
T cell deficiency involving Fas or FasL deficiency leads to...
ALPS
ALPS
???
Hyper IgE results from ____
Lack of Th1 or IFN-g production
RAG-deficiency leads to which type of SCID?
T-B-
Omenn is which type of SCID?
T+B-
X-linked SCID leads to which deficiency?
T-B+
BLS
??
Symptoms of GVHD
rash and diarrhea
normal proteins vs. viral proteins vs. oncogene products
??
5 diseases with strong MHC II association
Celiac disease
rheumatoid arthritis
pemphigus vulgaris
narcolepsy
Type I DM
Bacterial infections associated with Reiter's syndrome
Chlamydia

Shigella
Bacterial infection associated with Reactive arthritis
Salmonella
Viruses associated with MS
Hep B

EBV

HSV-6

Influenza A
6 symptoms of SLE
butterfly malar rash
joint pain
CNS abnormalities
heart disease
photosensitivity
kidney disease
UV light is associated with which autoimmune disease?
SLE
5 Type IV HSR diseases
allergic encephalitis
Celiac disease
Type I DM
MS
RA
3 autoimmune diseases in which the mediator is unknown
ankylosing spondylitis

reactive arthritis

Reiter's syndrome
Goodpasture's syndrome

- type of HSR
- target/antigen
-consequence
Type II

base membrane collagen in kidney, lung

nephritis, lung hemorrhage
Myasthenia Gravis

- type of HSR
-target/antigen
-consequence
Type II
AChR = target
muscle paralysis
Graves' Disease

Type of HSR
Target/Antigen
Consequences
Type II
TSH receptor
hyperthyroidism
Rheumatoid Factor
autoantibody against IgG

Found in 70% of RA cases
ANA
autoantibody against dsDNA

seen in SLE
early complement component deficiency found in which autoimmune disease?
SLE
major effector in Type I DM
CTL
Plasmapheresis and High doses of IgG are treatments specific for which kinds of autoimmune disease?
Ab-mediated

Immune-complex mediated
BCG vaccine =
live or attenuated intracellular bacteria
Complement deficiency makes the patient more susceptible to...
bacterial infection

autoimmunity
Deficiency in C3 -->
susceptible to pyogenic infection

fatal in early life
Deficiency in C2, C4 -->
high risk developing immune-complex diseases
Deficiency in C9 -->
susceptibility to Neisseria infection
host factors that prevent reandom cell lysis
C1 INH

DAF

MCP

CR1
C1 INH
C1 esterase inhibitor
HANE
deficiency in C1 INH

localized edema in airway, intestine, skin
PNH
caused by somatic DNA mutations in proteins essential for GPI production
GPI deficiency
spontaneous lysis of RBC, platelets, granulocytes

anema, TTP, chronic infection
LAD
leukocyte adhesion deficiency

autosomal recessive

defect in integrins affects WBC migration
symptoms of LAD
high WBC counts

no pus formation, no effective wound heaing

no classical signs during infection
CGD
chronic granulomatous disease

X-linked or autosomal recessive

defect in respiratory burst, affects phagocytic killing
symptoms of CGD
susceptible to low virulence bacteria

widespread granulomas, may obstruct stomach, esophagous or bladder
Chediak-Higashi Syndrome
autosomal recessive

defect in vesicle fusion affects degranuation & phagocytes
symptoms of Chediak Higashi
recurrent infection by pyogenic organisms

associated with neutropenia and massive infiltration of Mf and lymphocytes to liver, spleen, LN
4 types T cell deficiency
DiGeorge Syndrome
ALPS
Hyper-IgE syndrome
Hyper-IgM syndrome
ALPS
Autoimmune LymphoProliferative Syndrome

defective in Fas, FasL or Caspase 10
increasing number CD4-CD8- T cells
symptoms of ALPS
susceptible to chronic viral infection

prone to develop B cell lymphoma
Hyper-IgE syndrome
Th1 cells fail to produce IFN-gamma
Hyper-IgM syndrome
mutations in CD40, CD40L
XLA
X-lined infantile Agammaglobulinemia

mutation of btk blocking maturation from preB

virtual absence of B cells
symptoms of XLA
recurrent pyogenic bacteria infections
IgA deficiency symptoms
recurrent sinus and lung infections
T-B- types of SCID
ADA
PNP
RAG deficiency
T+B+ SCID
BLS
Cause of T-B+: X-linked SCID
mutation of common gamma-chain

normal B cell number but no function
Cause of T-B+: autosomal SCID
mutation of JAK3 Tyr-Kinase (mediates signaling downstream from common gamma receptor)
ADA deficiency causes
accumulation of toxins, impairing lymphocyte development
PNP deficiency causes...
toxin accumulation leading to damages in neuological and lymphoid tissues
BM transplant not recommended for which SCID?
Omenn
Etiology of Omenn syndrome
partial SCID with reduced RAG activity affecting only B cell development
3 SCID like multisystem disorders
ZAP-70 mutation
Wiskott-Adrich Syndrome
Ataxia Telangiectasia
Mechanisms of Wiskott-Aldrich
mutations in WASP
reduced T cell count
abnormal B & T cell function
Mechanism of ataxia telangiectasia
mutation in DNA repair protein
Tx for ADA deficiency
BM transplant

gene replacement

enzyme replacement
oncogene product
Bcr/Abl
USES OF IMMUNOASSAYS!
STUDY!
Ouchterlony tests...
if antigens are related
Agglutination is targeted at a _____ antigen

Precipitation is targeted at a ____ antigen
Agglutination - particle antigen

Precipitation - soluble antigen
FACS determines
cell types and numbers
IF detects
antigens embedded in tissues or cells
Mancini determines
protein concentration