Rheumatoid Arthritis Research

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Rheumatoid arthritis is disease, which is chronic in nature and causes severe inflammatory disorder that can affect more than the joints. It has the potential to damage essential components of our body like skin, eyes, lungs, heart and blood vessels. It is a situation, which happens when the immune system of one’s body starts attacking its own tissues. The rheumatoid arthritis is a bit different from osteoarthritis in the fact it starts impacting the lining of one’s joints along with a disastrous swelling which in turn leads to bone erosion and joint deformity. Finally it is justified to mention that it can cause physical disabilities as well (Becker, 2001).There are no specific events that have been identified that would cause immune abnormalities to develop into localized tissue and joint inflammation (McCance & Huether, 2014) . During inflammation, arginine can be enzymatically modified into another amino acid, citrulline, this process, citrullination, changes the structure and function of the protein (McCance & Huether, 2014) . Other proteins, like fibrin and vimentin, can become citrullinated during cell death and tissue inflammation (McCance & Huether, 2014) . The citrullincated proteins can be seen as antigens by the body’s immune system, thus, the T and B cells play a role in the autoimmune response (McCance & Huether, 2014) .Inflammation of synovial membranes results in panus or thickened synovium which adheres to articular cartilage and later erodes cartilage and underlying bone; adhesions develop between opposing joint surfaces and/or cyst grow (Uphold & Graham, …show more content…
(2001). Rheumatoid arthritis. Arthritis & Rheumatism, 24(2), 133–148. doi:10.1002/art.1780240204
Baum, J. (2011). Infection in rheumatoid arthritis. Arthritis & Rheumatism, 14(1), 135–137. doi:10.1002/art.1780140119
McCance, K. & Huether, S. (2014).Pathophysiology: The Biologic Basis for Disease in Adults and Children (7th ed). Chapter 44-Alterations ofMusculoskeletal

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