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27 Cards in this Set
- Front
- Back
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T-dependent antigens
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Proteins
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Polysaccharides, lipids, small chemicals, nucleic acids
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T-independent antigens
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B cell population that resides in follicles of lymph nodes
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Follicular B cells
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B cell population that resides in marginal zones of spleen
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Marginal zone B (MZB) cells
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B cell population that resides in mucosa and peritoneum
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B-1 B cells
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B cell populations that produce primarily IgM
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MZB cells and B-1 B cells
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Major antibody produced in primary response
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IgM
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Major antibody produced in secondary response
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IgG, IgA, IgE
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Components of B cell co-receptor complex
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CR2 (CD21); CD19; CD81
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Components of B cell antigen receptor complex
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BCR; Iga, Igb
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Ligand for CR2
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C3d (and iC3b)
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Anatomical site of activation of naive B cells
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B cell zones of lymphoid tissues
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Mechanism of helper T cell-induced activation of B cells
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CD40L and cytokines
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Effector mechanism of B cells in humoral immunity
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Secretion of antibodies
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Inducers of heavy chain isotype switching
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CD40L and cytokines
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Basis of X-linked hyper-IgM syndrome
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Defective CD40L
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Enzyme that induces switch recombination
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Activation-induced deaminase (AID)
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Major cytokine that induces switching to IgG
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IFNg
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Major cytokine that induces switching to IgE
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IL-4
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Major cytokine that induces switching to IgA
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TGFb
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Process that increases affinity of antibody for antigen
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Affinity maturation
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Anatomical site where affinity maturation occurs
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Germinal centers of lymphoid follicles
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Enzyme that results in numerous point mutations in Ig genes
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AID
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Mechanism of affinity maturation
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Somatic hypermutation
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This type of antigen induces primarily an IgM response
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T-independent antigens
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This type of antigen results in isotype switching
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T-dependent antigens
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Receptor that mediates antibody feedback
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FcgRII receptor
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