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29 Cards in this Set

  • Front
  • Back
Intracellular location of phagocytized microbes
Vesicles (phagolysosome)
Location of most intracellular pathogens that have invaded cells
Cytoplasm
T cell accessory molecule that binds co-stimulators
CD28
T cell accessory molecule involved in negative regulation of activated T cells
CTLA-4
APC molecule that provides second signal to T cells
B7
T cell accessory molecules involved in signal transduction
CD4, CD8, CD3 & z (zeta)
T cell accessory molecules involved in adhesion
LFA-1 and VLA-4
Substances that induce expression of co-stimulators on APCs
Adjuvants
Autocrine cytokine that promotes T cell proliferation
IL-2
Region of contact between APC and T cell
Immunologic synapse
Anatomical site of activation of T cells by APCs
Paracortex of lymph nodes
Tyrosine motifs on CD3 and z chains involved in signaling
ITAMs
Tyrosine kinase that triggers several signaling pathways
ZAP-70
High affinity version of the IL-2 Receptor
IL-2Rabgc
T cell population that defends against intracellular microbes
Th1
Cytokines that drive development of Th1 cells
IL-12, IFNg
Signature cytokines of Th1cells
Interferon-g, TNF, IL-2
T cell population that defends against extracellular microbes
Th2
Cytokine that drives development of Th2 cells
IL-4
Signature cytokines of Th2 cells
IL4, IL-5, IL-13
T cell population involved in inflammatory disorders
Th17
Signature cytokines of Th17
IL-17, IL-22
Cytokine that inhibits T cell activation
TGFb
Cytokine that induces B cell switching to produce IgE
IL-4
Cytokine that activates eosinophils
IL-5
T cell population that drives activation of macrophages and production of some classes of antibodies
Th1
T cell population that drives production of some classes of antibodies
Th2
T cell population that directly kills infected cells
CTLs
Ligand expressed on CD4+ T cells that makes APC better at stimulating T cells
CD40L