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27 Cards in this Set
- Front
- Back
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Prevent growth or destroy transformed cells by immune system
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Immune surveillance
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Mutated self proteins; products of oncogenes or mutated tumor suppressor genes; aberrantly expressed self proteins; oncogenic viruses
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Tumor antigens
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Mechanism of tumor cell destruction
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CTLs
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Failure to produce tumor antigens by malignant cells
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Mechanism of tumor evasion
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Mutations in MHC genes or genes needed for antigen processing in tumor cells
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Mechanism of tumor evasion
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Production of immunosuppressive proteins or expression of inhibitory cell surface proteins by tumor cells
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Mechanism of tumor evasion
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Grafts from identical animals
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Syngeneic
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Grafts from animals of the same species
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Allogeneic
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Grafts from animals that are from different species
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Xenogeneic
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Antigens of allografts that are targets of rejection
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MHC proteins
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Recipient T cells recognize donor allogeneic MHC molecules on graft dendritic cells
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Direct recognition
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Recipient T cells recognize processed donor alloantigens
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Indirect recognition
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In vitro model of T cell recognition of alloantigens used to predict outcomes of grafts
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Mixed lymphocyte reaction
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Graft rejection mediated by preformed antibodies that occurs in minutes
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Hyperacute
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Graft rejection mediated by T cells and/or antibodies that occurs within days or weeks
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Acute
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Graft rejection mediated by T cells that occurs over months to years
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Chronic
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Graft rejection characterized by complement activation, endothelial damage, inflammation and thrombosis
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Hyperacute
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Graft rejection characterized by parenchymal cell damage, interstitial inflammation and inflammation of the endothelium
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Acute
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Graft rejection characterized by DTH-induced fibrosis
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Chronic
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Drugs that block T cell cytokine production by inhibiting calcineurin
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Cyclosporine and FK506
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Drug that inhibits macrophage cytokine secretion
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Glucocorticoids
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Biologic agent that depletes T cells by promoting phagocytosis or complement-mediated lysis
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Anti-CD3 monoclonal antibody
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Biologic agent that inhibits T cell proliferation
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Anti-IL-2R antibody
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Drug that blocks lymphocyte proliferation by inhibiting guanine synthesis
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Mycophenolate mofetil
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Transplantation of blood cells
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Transfusion
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Preformed ABO antibodies react against transfused blood cells
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Transfusion reaction
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Mature allogeneic T cells attack recipient’s tissues
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Graft-vs.-host (GVH) disease
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