Immunology 2

Front 1

following recovery from a communicable disease such as measles, the type of immunity acquired is described as:
a) natural active
b) artificial active
c) natural passive
d) artificial passive
e) none of the above

Back 1

A: natural active

Front 2

immunity due to administration of live poliomyelitis vaccine is described as:
a) natural active
b) artificial active
c) natural passive
d) artificial passive
e) none of the above

Back 2

B: artificial active

Front 3

artificial passive immunity is employed in which of these situations:
a) tetanus antitoxin is administered to a nonimmunized person who has a dirty wound
b) an Rh-negative mother has given birth to an Rh-positive baby
c) exposure to infectious hepatitis
d) all of the above
e) none of the above
f) only a and c

Back 3

D: all of the above

Front 4

a harmful antibody/antigen reaction is termed:
a) allergy
b) hypersensitivity
c) infection
d) all of the above
e) only a and b above
f) none of the above

Back 4

E: only a and b
allergy and hypersensitivity

Front 5

in a susceptible person anaphylaxis may occur following:
a) injection of penicillin
b) insect sting
c) injection of an antigen
d) all of the above
e) only a and b
f) none of the above

Back 5

D: all of the above
injection of penicillian
insect sting
injection of ag

Front 6

terms synonymous with cellular immunity are:
a) delayed hypersensitivity
b) immediate hypersensitivity
c) tuberculin hypersensitivity
d) only a and c above
e) only b and c above

Back 6

D: only a and c
delayed hypersensitivity
tuberculin hypersensitivity

Front 7

the increase in vascular permeability observed in man and guinea pigs in cutaneous anaphylatctic reactions results mainly from the liberation of:
a) histamine
b) 5-hydroxy tryptamine
c) SRS-A
d) adrenaline
e) serotonin
f) none of the above
g) all of the above
h) histidine

Back 7

A: histamine

Front 8

what inflammatory cell is most characteristic of lesions produced by antigen-antibody-complelment complexes:
a) T lymphocytes
b) macrophages
c) basophils
d) polymorphonuclear neutrophils
e) eosinophils
f) mast
g) none of the above

Back 8

D: polymorphonuclear neutrophils

Front 9

the organ most easily affected in chronic immune complex diseases both in experimental animals and in man is:
a) kidney
b) liver
c) lung
d) brain
e) none of the above

Back 9

A: kidney

Front 10

M.I.F. refers to:
a) migration inhibitory factor for macrophages
b) major inflammatory factor of delayed sensitivity
c) mildly interesting fiction
d) medicine is finished
e) mutation inhibitory factor
f) migration inhibitory factor for lymphocytes
g) none of the above

Back 10

A: migration inhibitory factor for macrophages

Front 11

the mode of action of antihistamines in relieving the symptoms of allergy is by:
a) inhibiting IgE production
b) blocking histamine binding to cell membranes
c) inhibiting histamine production
d) blocking the binding of pollen to histamine
e) inhibiting histamine release

Back 11

B: blocking histamine binding to cell membranes

Front 12

which of the following is not produced by sensitized Tdh lymphocytes:
a) migration inhibitory factor
b) transfer factor
c) chemotactic factor
d) interleukin 1
e) interferon gamma

Back 12

D: interluekin 1

Front 13

all RBC and WBC originate from this tissue

Back 13

bone marrow

Front 14

universal blood donor is what type

Back 14

O

Front 15

measure of strength of interaction between Ab and its epitope

Back 15

affinity

Front 16

most important mediator released from mast cells in immediate hypersensitivity reaction

Back 16

histamine

Front 17

most important memory cell type in tumor immunity

Back 17

CTL

Front 18

hemolytic disease of newborne primarily caused by Ab of this class

Back 18

IgG

Front 19

Ab are found in this specific plasma protein fraction

Back 19

gamma globulin

Front 20

fetus and newborn best able to synthesize this Ig class

Back 20

IgM

Front 21

synonym for class when referring to immunoglobulin

Back 21

isotype

Front 22

Ag specificities which are different in different groups of individuals within the same species

Back 22

allotype

Front 23

peculiar to a single Ab type made in a single individual of a given species to a single determinant

Back 23

idiotype

Front 24

cytokine most central to development of adaptive immune response

Back 24

IL2

Front 25

fetal cell layer found on placental interface between fetus and maternal host

Back 25

trophoblast

Front 26

very high density of microvilli by EM are seen on surface of this lymphocyte

Back 26

B cell

Front 27

substance that is not immunogenic but can react with Ab of appropriate specificity

Back 27

hapten

Front 28

lymphokine toxic to tumor cells in immunological surveillance

Back 28

TNF

Front 29

most predominant type of lymphocyte found in normal human blood

Back 29

T cell

Front 30

substance (antigen) that causes an allergic response

Back 30

allergen

Front 31

used to detect presence of nonhemagglutinating IgG on surface of human RBC

Back 31

antihuman IgG

Front 32

Ab class important in systemic anaphylaxis

Back 32

IgE

Front 33

a large molecular weight antigen can have many different antibody specific molecules bound to it

Back 33

true

Front 34

immunological memory can last twenty years or longer in humans

Back 34

true

Front 35

sheep t cells form rosettes with uncoated human RBC

Back 35

false
HUMAN t cells form rosettes with uncoated SHEEP RBC

Front 36

b cells capable of responding to a specific antigen are already present within the lymphoid tissue prior to exposure to the antigen

Back 36

true

Front 37

rheumatoid factor is IgM directed agaisnt the Fc of IgG and results in an autoimmune disease

Back 37

true

Front 38

the Fc of IgG has cytophilic properties but cannot activate the complement system

Back 38

false
the Fc of IgG has cytophilic properties and CAN activate the complement system

Front 39

F (ab')2 can be produced from IgG with papain treatment

Back 39

false
F (ab')2 can be produced from IgG with PEPSIN treatment

Front 40

penicillin is a hapten that can bind to IgE if specific

Back 40

true

Front 41

the immediate hypersensitivity skin test peaks at 48 hours in humans

Back 41

false
the DELAYED hypersensitivity skin test peaks at 48 hours in humans
or
the immediate hypersensitivity skin test peaks at 20 MIN in humans

Front 42

in arthus skin reaction, neutrophils would be found intradermally

Back 42

true

Front 43

the dealyed hypersensetive skin test is cell mediated by mononuclear cells

Back 43

true

Front 44

fish produce only the IgM antibody class

Back 44

true

Front 45

the MAF lymphokine, produced by Tdh, is required for activation of macrophages to kill tumor cells by direct contact

Back 45

true

Front 46

IL2 and TF monokines both recruit uncommitted T cells to a specific Ag

Back 46

false
IL2 and TF lymphokines both recruit uncommitted T cells to a specific Ag

Front 47

TNF alpha is a monokine produced by activated macrophages

Back 47

true

Front 48

the IL2 lymphokine, produced by Th1, activates cytotoxic T cells

Back 48

true

Front 49

affinity refers to the binding strength of an Fab for its specific antigenic determinant

Back 49

true

Front 50

the hypervariable regions of Vh and Vl are important in determining specificity of an Ab molecule

Back 50

true

Front 51

RBC contain blood roup Ag for the RBC typing needed for transfusion of the blood

Back 51

true

Front 52

eosinophils, basophils, and neutrophils are all polymorphonuclear leucocytes and are agranulocytes

Back 52

false
eosinophils, basophils, and neutrophils are all polymorphonuclear leucocytes and are AGRANULOCYTES

Front 53

neutrophils increase during bacterial infections, whereas T lymphocytes increase during viral infection

Back 53

true

Front 54

monocytes and T lymphocytes are agranular mononuclear leucocytes

Back 54

ture

Front 55

NK cells are null cells and are large granular lymphocytes

Back 55

true

Front 56

the H substance is an obligatory precursor substance to which the A and B groups are attached in the ABO blood group system

Back 56

true

Front 57

anti A and anti B antibodies (ABO system) are mainly IgG antibody

Back 57

false
anti A and anti B antibodies (ABO system) are mainly IgM antibodies

Front 58

a transfusion reaction is an attack on the donor RBC by recipient antibdoy

Back 58

true

Front 59

IgE shows cytophilic affinity for monocytes

Back 59

false
IgE shows cytophillic affinity for MACROPHAGES and MAST CELLS

Front 60

histamine is derived by decarboxylation of histidine and causes contraction of smooth muscle

Back 60

true

Front 61

secretory IgA is important in passive artificial immunity

Back 61

false
secretory IgA is important in passive NATURAL immunity

Front 62

in the graft-vs-host response, donor T lymphocytes attack the recipient cells

Back 62

true

Front 63

mast cells have crucial role in allergies caused by IgG

Back 63

false
mast cells have crucial role in allergies caused by IgE

Front 64

hemolytic disease of the newborn is due to production of maternal IgG specific for erythrocyte Rh antigen

Back 64

true

Front 65

in the early stages of an inflammatory response, the predominant cell type infiltrating tissue is the neutrophil

Back 65

true

Front 66

the tuberculin skin test is an example of an immediate hypersensitivity skin test

Back 66

false
the TB skin test is an example of a DELAYED hypersensitivity skin test

Front 67

IgG rather than IgM is most likely to have evolved first in animals

Back 67

false
IgM rather than IgG is most likely to have evolved first in animals

Front 68

the mast cell is nonphagocytic but has Fc receptors for IgE

Back 68

true

Front 69

macrophages found in the liver are called kupffer cells

Back 69

true

Front 70

the intrauterine fetus is actually an allograft

Back 70

true

Front 71

'blocking Ab' in desensitization therapy against atopic allergies is IgG

Back 71

true

Front 72

erythroblastosis fetalis would involve an Rh negative fetus and an Rh positive maternal host

Back 72

false
erythroblastosis fetalis would involve an Rh POSITIVE fetus and an Rh NEGATIVE maternal host

Front 73

in the arthus reaction, you are in Ag excess and IgG is involved

Back 73

false
in the arthus reaction, you are in Ab excess and IgG is involved

Front 74

in serum sickness, you are in Ab excess and IgG is involved

Back 74

false
in serum sickness, you are in Ag excess and IgG is involved

Front 75

high affinity IgG antibody is found in a secondary Ab response

Back 75

true

Front 76

poison ivy is an example of immediate hypersensitivity

Back 76

false
poison ivy is an example of DELAYED hypersensitivity response

Front 77

_________ receptors on neutrophil or macrophage surface bind antibody boated bacterium

Back 77

Fc

Front 78

_________ are antibody or complement components that bind to pathogens and hereby facilitate and enhance their phagocytosis

Back 78

opsonins

Front 79

neutrophil or macrophage cell membranes surround bacteria and fuse, creating a membrane bound vesicle or ____________

Back 79

phagosome

Front 80

__________ occurs first during phagocytosis with the generation of toxic oxygen metabolites

Back 80

the sp burst

Front 81

__________, containing digestive enzymes, fuse second with the intracellular vesicle

Back 81

lysosomes

Front 82

__________ at the site of an infection is initiated by the chemotactic response of phagocytic cells migrating into the tissues

Back 82

inflammation