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8 Cards in this Set
- Front
- Back
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Allograft
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relates to genetically distinct individuals of the same species
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Isograft
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relates to genetically identical individuals of the same species
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Autologous
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transplants w/i one individual
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Homograft
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a graft from the same species
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Xenograft
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a graft from another species
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Hyperacute alloreactivity
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very rapid (hours or even minutes)
can be a problem w/ xenotransplants and is usually linked to antibody via type III hypersensitivity or othe mechanisms of complement activation in allografts it can be linked to incompatibility of ABO blood group antigens which is type II |
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Acute alloreactivity
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short term process (days to weeks)
violent immune process and it involves large scale activation of T cells T cells release cytokines eventually leading to tissue distortion, vascular insufficiency, and cell destruction histologically leukocytes are present dominated by equivalent numbers of macrophages and t cells |
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Chronic alloreactivity
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long term (years) process involving cellular immune activation but much less so than in the acute process
clinical and lab finding are very similar to autoimmunity w/ lymphocytic infiltrates organs and tissues eventually become fibrosed w/ loss of tissue function |
