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17 Cards in this Set

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allele
one of two gene forms present at a specific locus
CD4+ T cells
T cells whose role is cytokine secretion
CD8+ T cells
T cells whose role is cytotoxicity
class I MHC (major histocompatibility complex)
proteins present on all nucleated cells, antigenic fragments are displayed on the target cell surface within the protein groove
class I MHC restriction
refers to the fact that the antigen receptors on CD8+ T cells can only recognize antigenic fragments displayed on the groove of class I MHC proteins
class II MHC (major histocompatibility complex)
proteins present on all APCs, antigenic fragments are displayed within their groove, complex on cell surface
class II MHC restriction
refers to the fact that antigen receptors on CD4+ T cells can only recognize antigenic fragments when displayed with class II MHC on the surface of an antigen presenting cells
codominant expression
both alleles are expressed
costimulatory molecules
molecules that are required for activation of some cells
endosome
a vacuole that is formed within the cytosol
human leukocyte antigens (HLA)
in humans the MHC proteins may also be referred to as HLA proteins
invariant chain (Ii)
a protein that is the same in all cells, blocks the class II MHC antigen binding site in the endoplasmic reticulum
polymorphism
the occurrence of different forms of particular MHC proteins within a population
professional antigen presenting cell
cells whose primary role is to present antigen to T cells
proteasome
a complex of proteolytic enzymes that degrade cytosolic proteins to which ubiquitin has been attached
transporter of antigen processing (TAP)
proteins to which peptides that have been degraded by the proteasome bind to enter the endoplasmic reticulum
beta-2-microglobulin
the invariant chain of the class I MHC cell surface protein