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40 Cards in this Set

  • Front
  • Back
alternative pathway of complement
pathway that is initiated by C3b, assoc. with innate immunity
anaphylatoxin
C3a, C4a, C5a. binding to their receptors on mast cells and basophils induces degranulations
anaphylatoxin inhibitor
a protein that inactivates the anaphylatoxins (C3a, C4a, C5a)
Ba
proteolytic fragment of Factor B following cleavage by Factor D
Bb
proteolytic fragment of Factor B following cleavage by Factor D, forms part of the C3 convertase AP
C1 inhibitor protein (C1 INH)
a protein that binds to C1 to prevent its activation, when unbound C1 leaves C4 and C2
C1 through to C9
proteins of the classical pathway
C2b
a weak kinin, and so can increase vascular permeability, it is a proteolytic fragment of C2
C3 convertase (AP)
C3bBb
C3 convertase (CP)
C4b2a
C3 tickover
term which refers to the spontaneous production of C3b which will activate AP of complement
C3a, C4a, C5a
anaphylatoxins - released from proteolytic cleavage of C3, C4, C5
C3b
proteolytic fragment of C3, an opsonin, activates alternative pathway, a component of both pathways
C4bp
regulatory protein, binds to C4b preventing its attachment to cells, promotes dissociation of C3 convertase
C5 convertase (AP)
C3bBbC3b
C5 convertase (CP)
C4b2a3b
CD59
membrane attack complex inhibitor, regulatory protein
classical pathway of component
pathway that is initiated by IgM or IgG immune complexes
CR1
complement receptor 1, receptor for C3b
CR2
complement receptor 2, receptor for C3bi
CR3a/4a
complement receptor 3a/4a, receptor for the anaphylatoxins C3a, C4a
CR5a
complement receptro C5a, receptor for the anaphylatoxin C5a
decay accelerating factor (DAF)
regulatory protein, prevents formation of, or causes dissociation of C3 convertases (binds C4b and C3b)
Factor B
component of the alternative pathway of complement, binds to deposited C3b
Factor D
enzyme that cleaves bound Factor B
Factor H
regulatory protein that binds C3b and so can prevent binding of Factor B to C3b, or cause the dissociation of C3bBb
Factor I
regulatory protein that requires one of several cofactors, cleaves soluble forms of C3b and of C4b
glycosylphosphatidylinositol (GPI)
molecule that serve to attach some proteins to the cell in leiu of a transmembrane domain
hereditary angioedema (HAE)
complement disorder caused by a genetic deficiency of C1 INH
homologous restriction factor (HRF)
MAC inhibitor, regulatory protein
kallikrein
formed during intrinsic coagulation pathway activation
kininogen
protein that is a substrate for kallikrein, bradykinin released
membrane attack complexes (MAC)
complex composed of C5b, 6, 7, 8, 9. complex inserts into the membrane to cause cell lysis
Neisseria species
bacterial species-MAC protein deficiencies (especially C8) results in recurrent infection with these bacteria
paroxysmal nocturnal haemoglobulinuria (PNH)
inherited disorder that manifests as hemolytic anemia because of genetic defect in GPI linkages
properdin
protein that stabilizes the alternative pathway C3 convertase
S protein
MAC inhibitor-regulatory protein
terminal pathway
alternative and classical pathways converge to form this pathway leading to MAC formation
vitronectin
MAC inhibitor-regulatory protein
xenograft
graft from another species