Immuno Five: Complement

Front 1

alternative pathway of complement

Back 1

pathway that is initiated by C3b, assoc. with innate immunity

Front 2

anaphylatoxin

Back 2

C3a, C4a, C5a. binding to their receptors on mast cells and basophils induces degranulations

Front 3

anaphylatoxin inhibitor

Back 3

a protein that inactivates the anaphylatoxins (C3a, C4a, C5a)

Front 4

Ba

Back 4

proteolytic fragment of Factor B following cleavage by Factor D

Front 5

Bb

Back 5

proteolytic fragment of Factor B following cleavage by Factor D, forms part of the C3 convertase AP

Front 6

C1 inhibitor protein (C1 INH)

Back 6

a protein that binds to C1 to prevent its activation, when unbound C1 leaves C4 and C2

Front 7

C1 through to C9

Back 7

proteins of the classical pathway

Front 8

C2b

Back 8

a weak kinin, and so can increase vascular permeability, it is a proteolytic fragment of C2

Front 9

C3 convertase (AP)

Back 9

C3bBb

Front 10

C3 convertase (CP)

Back 10

C4b2a

Front 11

C3 tickover

Back 11

term which refers to the spontaneous production of C3b which will activate AP of complement

Front 12

C3a, C4a, C5a

Back 12

anaphylatoxins - released from proteolytic cleavage of C3, C4, C5

Front 13

C3b

Back 13

proteolytic fragment of C3, an opsonin, activates alternative pathway, a component of both pathways

Front 14

C4bp

Back 14

regulatory protein, binds to C4b preventing its attachment to cells, promotes dissociation of C3 convertase

Front 15

C5 convertase (AP)

Back 15

C3bBbC3b

Front 16

C5 convertase (CP)

Back 16

C4b2a3b

Front 17

CD59

Back 17

membrane attack complex inhibitor, regulatory protein

Front 18

classical pathway of component

Back 18

pathway that is initiated by IgM or IgG immune complexes

Front 19

CR1

Back 19

complement receptor 1, receptor for C3b

Front 20

CR2

Back 20

complement receptor 2, receptor for C3bi

Front 21

CR3a/4a

Back 21

complement receptor 3a/4a, receptor for the anaphylatoxins C3a, C4a

Front 22

CR5a

Back 22

complement receptro C5a, receptor for the anaphylatoxin C5a

Front 23

decay accelerating factor (DAF)

Back 23

regulatory protein, prevents formation of, or causes dissociation of C3 convertases (binds C4b and C3b)

Front 24

Factor B

Back 24

component of the alternative pathway of complement, binds to deposited C3b

Front 25

Factor D

Back 25

enzyme that cleaves bound Factor B

Front 26

Factor H

Back 26

regulatory protein that binds C3b and so can prevent binding of Factor B to C3b, or cause the dissociation of C3bBb

Front 27

Factor I

Back 27

regulatory protein that requires one of several cofactors, cleaves soluble forms of C3b and of C4b

Front 28

glycosylphosphatidylinositol (GPI)

Back 28

molecule that serve to attach some proteins to the cell in leiu of a transmembrane domain

Front 29

hereditary angioedema (HAE)

Back 29

complement disorder caused by a genetic deficiency of C1 INH

Front 30

homologous restriction factor (HRF)

Back 30

MAC inhibitor, regulatory protein

Front 31

kallikrein

Back 31

formed during intrinsic coagulation pathway activation

Front 32

kininogen

Back 32

protein that is a substrate for kallikrein, bradykinin released

Front 33

membrane attack complexes (MAC)

Back 33

complex composed of C5b, 6, 7, 8, 9. complex inserts into the membrane to cause cell lysis

Front 34

Neisseria species

Back 34

bacterial species-MAC protein deficiencies (especially C8) results in recurrent infection with these bacteria

Front 35

paroxysmal nocturnal haemoglobulinuria (PNH)

Back 35

inherited disorder that manifests as hemolytic anemia because of genetic defect in GPI linkages

Front 36

properdin

Back 36

protein that stabilizes the alternative pathway C3 convertase

Front 37

S protein

Back 37

MAC inhibitor-regulatory protein

Front 38

terminal pathway

Back 38

alternative and classical pathways converge to form this pathway leading to MAC formation

Front 39

vitronectin

Back 39

MAC inhibitor-regulatory protein

Front 40

xenograft

Back 40

graft from another species