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42 Cards in this Set

  • Front
  • Back
affinity maturation
the consequence of genetic mutations in the hypervariable region following B cell activation and isotype switching
anti-idiotype antibodies
antibodies that are directed to the hypervariable regions of the light and heavy chains
Btk kinase
a tyrosine kinase required for B cell development its genetic deficiency leads to X-linked agammaglobulinemia
a molecule on the surface of B cells - can be used as a panmarker for enumeration of identification of B cells
a molecule present on T cells and NK cells - used as a panmarker for T cells (with contaminating NK cellS)
CD40 is present on B cells and other antigen presenting cells, CD40L is presenton T cells
a tyrosine phosphatase
molecules that are expressed in association with mIg on the surface of B cells
class II MHC
molecules that present antigen to CD4+ T cells
clonal expansion
the sequential binary division of a cell following appropriate stimulation
a low affinity receptor for the Fc region of the IgG antibodies
region of immune tissues in whcih B cells predominate
GTPase activating protein (GAP) which results in th inactivation of GTP by converting it to GDP
germinal center
the region of the follicle in which B cells undergo proliferation and other differentiation events following activation
guanine exchange factor (GEF)
exchanges GDP with GTP
high endothelial venules
venules in lymph nodes, sites at which lymphocytes leave the blood and enter lymph nodes
hyper IgM syndrome
a disorder resulting from the defect in CD40-CD40 ligand interaction (usually deficiency in CD40L on T cells)
decrease in level of antibodies in serum
a counter molecule for the adhesion molecule (LFA-1)
isotype switching
the consequence leads to the expression of IgG, IgA, or IgE on the activated B cell surface (instead of IgM and IgD)
ITAM (Skip)
immunoreceptor tyrosine based activation motif (contains tyrosine that will be phosphorylated by tyrosine kinases)
ITIM (Skip)
immunoreceptor tyrosine based inhibition motif (contains tyrosine that will be phosphorylated by tyrosine kinases)
L selectin
a molecule on lymphocytes, interacts wtih counter molecules on HEV to induce rolling of lymphocytes
leukocyte function associated antigen-1, adhesion molecule present on many cells including B and T cells
LFA-3 adhesion molecule whose ligand is CD2
lipopolysaccharide (LPS)
at high concentrations LPS is a polyclonal activator of B cells
memory cells
differentiated lymphocytes that are not destroyed following B cell or T cell activation (immunosurveillance)
B cell receptor, membrane immunoglobulin, or cell surface antibodies
p21 ras (Skip)
molecule that activates the raf kinase and so initiates activation of a kinase cascade
phosphatase (tyrosine) (skip)
a protein that removes phosphate groups from tyrosine residues
phospholipase C gamma (Skip)
a protein whose activation leads to production of diacylglycerol (DAG) and inositol triphosphate (IP3)
pneumococcal polysaccharide
a T-independent antigen, also component of a capsule in some bacteria
primary immune response
immune response following first exposure to antigen
secondary immune response
immune response following subsequent exposure to antigen
SH2 (skip)
src homology 2 domain
somatic mutation
mutations occurring in the DNA encoding the hypervariable region, following B cell activation
src family kinase (Skip)
kinases that are similar to the src kinase both in structure and function (src kinases are tyrosine kinases)
switch recombination
process following B cell activation in which the DNA of some constant regions is excised (isotype switching)
T-dependent antigen
an antigen to which B cells can only respond if T cells deliver the appropriate signals
T-independent antigen
an antigen to which B cells can be activated in the absense of cognate interaction with T cells
transient hypogammaglobulinemia of infancy
transient deficiency in serum antibodies
x-linked agammaglobulinemia (x-linked hypogammaglobulinemia, Bruton's aggammaglobulinemia)
immunodeficiency disorder resulting from a defect in the Btk kinase