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21 Cards in this Set

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adaptive immunity
that part of the immune system that is specific and has memory (B and T cells)
antibodies
molecules that are secreted by plasma cells and bind to antigen in a specific manner
antigen
classic definition: molecules that have specific sequences to which adaptive immune responses can be generated
antigenicity
a property of molecules to which an adaptive immune response can be generated
antigenic determinant
syn: epitope. A particular component of an antigen that is recognized by unique lymphocyte receptors (that component of an antigen that is recognized by B or T cells [T cells only recognize antigens displayed with MHC])
Bursa of fabricius
tissue where B cells mature from progenitor cells (in chickens)
complement
a host defense sustem consisting of soluble and membrane-bound proteins
chemokines
small molecules that were originally identified because of their role in attracting cells to a particular region
cytokines
molecules that are secreted primarily (but not exclusively) by cells of the immune system. These molecules play an important role in the activation and in down-regulation of immune responses
determinant
syn: epitope. A particular component of an antigen that is recognized by unique lymphocyte receptors (that component of an antigen that is recognized by B or T cells [T cells only recognize antigens displayed with MHC])
epitope
A particular component of an antigen that is recognized by unique lymphocyte receptors (that component of an antigen that is recognized by B or T cells [T cells only recognize antigens displayed with MHC])
follicle associated epithelium (FAE)
that region of the luminal epithelium that is not covered by mucus (part of MALT system)
germinal center
that component of a follicle where antigen-induced B cell differentiation occurs
hapten and carrier
a small molecule (<6kd) that is not immunogenic unless it binds to a carrier protein, permitting anti-hapten immune response
hematopoiesis
a term used to refer to the differentiation of various cell types from a pluripotent stem stell. Cytokines play an important role in this process
immunogenicity
syn: antigenicity. refers to a molecule that can serve as teh stimulus for an adaptive immune response
innate immunity
that component of immunity in which cells and effectors do not have memory, nor receptors specific for an epitope
mitogen
polyclonal activator
periarteriolar lymphatic sheath (PALS)
region containing the white pulp
white pulp
that region of the spleen within PALS, predominant immune cell is the T cell and is where the primary T cell responses can occur
tolerance (self tolerance)
refers to the fact that the immune system is not pathologically activated in the presence of its own antigens