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15 Cards in this Set
- Front
- Back
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What are streptokinase, urokinase, tPA (alteplase), APSAC (anistreplase)?
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Thrombolytics
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What is the mechanism of thrombolytics?
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Directly or indirectly aid conversion of plasminogen to plasmin
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What would you expect for PT, PTT and platelet count when using thrombolytics?
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Increased PT and PTT, no change in platelet count
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What is the clinical use of thrombolytics?
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Early MI, early ischemic stroke
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What is the toxicity of thrombolytics?
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Bleeding
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What do you use in thrombolytic toxicity?
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Aminocaproic acid
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What is the mechanism of aspirin?
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Acetylates and irreversibly inhibits COX-1 and COX-2 to prevent conversion of arachidonic acid to thromboxane A2
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What effect does aspirin have on PT and PTT?
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None
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What is the clinical use of aspirin?
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Antipyretic, analgesic, anti-inflammatory, antiplatelet
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What is the toxicity of aspirin?
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Gastric ulceration, bleeding, hyperventilation, Reye's syndrome, tinnitus (CN VIII)
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What is the mechanism of clopidogrel and ticlopidine?
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Inhibit platelet aggregation by irreversibly blocking ADP receptors and inhibit fibrinogen binding by preventing glycoprotein IIb/IIIa expression
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What is the toxicity of ticlopidine?
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Neutropenia
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What is the mechanism of abciximab?
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Monoclonal antibody that binds to the glycoprotein receptor IIb/IIIa on activated platelets, preventing aggregation
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What is the clinical use of abciximab?
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Acute coronary syndrome, percutaneous transluminal angioplasty
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What is the toxicity of abciximab?
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Bleeding, thrombocytopenia
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