Hypertension and Leptin
The cumulative effect of Leptin administered for short term on blood pressure in the conditions of a healthy subject are negligible. The sympathetic activity of the nervous system is activated by Leptin in lean animals (Peckett, Wright, & Riddell, 2011). However, a balance is created by the vasorelaxation that is NO-dependent and natriuresis in the event which the blood pressure is kept constant. However, prolonged hyperleptinaemia leads to an increase in the blood pressure, this is because of the impair to the effect of acute depressors and the cumulative sympathetic nervous systems that causes appearance of independent pressor effect which is inclusive of NO deficiency, oxidative stress, enhanced renal sodium ion, …show more content…
Also, there is a substantial positive correlation between high blood pressure and Leptin which is independent of the body adiposity in both the hypertensive and normotensive individuals. Gender is found to be the greatest determinant in the correlation between Leptin and high blood pressure (Peckett, Wright, & Riddell, 2011). Despite the higher levels of serum Leptin in female, the correlation of Leptin and blood pressure have been reportedly found in men more than in women, this is irrespective of adiposity and hypertension. It is also influenced by the racial and ethnic backgrounds of an individual. These levels of correlation have been noted only after the conduction of efonidipine therapy to the …show more content…
It has also been proved that impaired fibrinolysis is important in the development of atherothrombotic disease and that it raises the hazard of myocardial infarction, it has also shown the possibilities of reinfarction and death after the myocardial infarction (Lass, 2011). The major controllers of the fibrinolytic activity are the plasminogen activators tissues (tPA) which then up-regulates the fibrinolysis, and the inhibitor- 1 plasminogen activator (PAI-1), this has a positive effect, which inhibits the fibrinolytic process (Park, Bae, & Cho,
The cumulative effect of Leptin administered for short term on blood pressure in the conditions of a healthy subject are negligible. The sympathetic activity of the nervous system is activated by Leptin in lean animals (Peckett, Wright, & Riddell, 2011). However, a balance is created by the vasorelaxation that is NO-dependent and natriuresis in the event which the blood pressure is kept constant. However, prolonged hyperleptinaemia leads to an increase in the blood pressure, this is because of the impair to the effect of acute depressors and the cumulative sympathetic nervous systems that causes appearance of independent pressor effect which is inclusive of NO deficiency, oxidative stress, enhanced renal sodium ion, …show more content…
Also, there is a substantial positive correlation between high blood pressure and Leptin which is independent of the body adiposity in both the hypertensive and normotensive individuals. Gender is found to be the greatest determinant in the correlation between Leptin and high blood pressure (Peckett, Wright, & Riddell, 2011). Despite the higher levels of serum Leptin in female, the correlation of Leptin and blood pressure have been reportedly found in men more than in women, this is irrespective of adiposity and hypertension. It is also influenced by the racial and ethnic backgrounds of an individual. These levels of correlation have been noted only after the conduction of efonidipine therapy to the …show more content…
It has also been proved that impaired fibrinolysis is important in the development of atherothrombotic disease and that it raises the hazard of myocardial infarction, it has also shown the possibilities of reinfarction and death after the myocardial infarction (Lass, 2011). The major controllers of the fibrinolytic activity are the plasminogen activators tissues (tPA) which then up-regulates the fibrinolysis, and the inhibitor- 1 plasminogen activator (PAI-1), this has a positive effect, which inhibits the fibrinolytic process (Park, Bae, & Cho,