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26 Cards in this Set
- Front
- Back
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What is the function of LTB4?
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Neutrophil chemotactic agent
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What is the function of LTC4, D4 and E4?
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Bronchoconstriction, vasoconstriction, contraction of smooth muscle, increased vascular permeability
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What is the function of PGI2?
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Inhibition of platelet aggregation and promotion of vasodilation, decrease bronchial tone and uterine tone
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What is the function of PGE and PGF?
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Decreased vascular tone, decreased bronchial tone, and increased uterine tone
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What is the function of thromboxane?
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Increased platelet aggregation, increased vascular tone, increased bronchial tone
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What are ibuprofen, naproxen, indomethacin, ketorolac?
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NSAIDs
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What is the clinical use of NSAIDs?
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Antipyretic, analgesic, anti-inflammatory; indomethacin used to close PDA and for acute gout
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What is the mechanism of NSAIDs?
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Reversibly inhibit COX-1 and COX-2 blocking prostglandin synthesis
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What is the toxicity of NSAIDs?
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Renal damage, aplastic anemia, GI distress, ulcers
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What is the clinical use of celecoxib?
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Rheumatoid arthritis and osteoarthritis
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What is the mechanism of celecoxib?
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COX-2 inhibitor: reversibly inhibits COX-2: mediates inflammation and pain while sparing GI lining corosion
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What is the toxicity of celecoxib?
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Increased risk of thrombosis, sulfa allergy, less toxicity to GI mucosa than NSAIDs
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What is the clinical use of acetominophen?
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Antipyretic, analgesic, but not anti-inflammatory
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What is the mechanism of acetominophen?
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Reversibly inhibits cyclooxygenase, mostly in the CNS. Inactivated peripherally.
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What is the toxicity of aceteminophen?
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Overdose can cause hepatic necrosis
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What is the clinical use of colchicine?
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Acute gout
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What is the mechanism of colchicine?
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Depolymerizes microtubules --> impairs leukocyte chemotaxis and degranulation
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What is the toxicity of colchicine?
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GI side effects, especially if given orally
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What is the clinical use of probenecid?
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Chronic gout
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What is the mechanism of probenecid?
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Inhibits reabsorption of uric acid in the PCT (also inhibits secretion of penicillin)
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What is the clinical use of allopurinol?
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Chronic gout, lymphoma and leukemia to preven tumor-lysis-associated urate nephropathy
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What is the mechanism of allopurinol?
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Inhibitis xanthina oxidase --> decreases conversion of xanthine to uric acid
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What drugs interact with allopurinol?
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Azathioprine and 6-MP
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What is etanercept and what is the clinical use?
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Recombinant TNF; Rheumatoid arthritis, psoriasis, ankylosing spondylitis
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What is infliximab and what is the clinical use?
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Anti-TNF Ab; Crohn's disease, rheumatoid arthritis, ankylosing spondylitis
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What is the toxicity of infliximab?
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Predisposes to infections, esp reactivation of latent TB
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