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63 Cards in this Set
- Front
- Back
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which drugs are cell cycle non-specific?
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- alkylating agents, antitumor antibiotics (anthracyclines)
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which drugs are S-phase specific?
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- anti-metabolites (methotrexate, 5-FU, cytarabine)
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which drugs are M phase specific?
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- alkaloids b/c affect MTs (vinca alkaloids - vincristine, vinblastine) & (taxanes - paclitaxel, docetaxel)
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what 3 drugs are associated with delayed N/V after chemo?
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- cisplatin, cyclophosphamide, doxorubicine
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what is doxorubicin?
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- anthracycline
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what is daunorubicin?
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- anthracycline
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what is mitoxantrone?
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- anthracycline
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what is ondanestron?
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- serotonin antagonist = zofran (anti-emetic)
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what is palanosetron?
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- serotonin antagonist - prolonged half life --> 1 dose/chemo cycle (anti-emetic)
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what is aprepitant?
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- NK-1 antagonist (anti-emetic)
- used for cisplatin - toxicities w/ dexamethasone b/c metabolized by P450 system |
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what is prochloperazine?
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- dopamine antagonist (anti-emetic)
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what is metoclopramide?
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- dopamine antagonist (anti-emetic)
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what is perphenazine?
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- dopamine antagonist (anti emetic)
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what is dexamethasone?
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- corticosteroid
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what is procrit?
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- EPO to treat anemia
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what is filgrastim?
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- GCSF
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what is pegilgrastim?
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- GCSF
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what is sargramostim?
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- GMCSF
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what are the two metabolites of cyclophosphamide?
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- phosphoaramide mustard (active alkylating agent)
- acrolein (metabolite that causes urotoxicity |
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what is dihydrotestosterone?
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- androgen/hormonal agent
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what is danazol?
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- androgen/hormonal agent
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what is flutamide? side effects?
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- anti-androgen therapy used for prostate cancer
- SE: hot flashes, decreased libido, gynecomastia, transient LFTs |
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what is bicalutamide? side effects?
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- anti-androgen therapy used for prostate cancer
- SE: hot flashes, decreased libido, gynecomastia, transient LFTs |
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what is nilutamide? side effects?
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- anti-androgen therapy used for prostate cancer
- SE: hot flashes, decreased libido, gynecomastia, transient LFTs |
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what is tamoxifen? side effects?
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- anti-estrogen used for breast cancer
- menopausal symptoms = hot flashes, sweats, edema, DVT, endometrial hyperplasia (pro estrogenic there) |
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what is letrozole? side effects?
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- aromatase inhibitor (post menopausal breast cancer)
- menopausal symptoms = hot flashes, sweats, edema, DVT, endometrial hyperplasia (pro estrogenic there) |
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what is anastrozole? side effects?
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- aromatase inhibitor (post menopausal breast cancer)
- menopausal symptoms = hot flashes, sweats, edema, DVT, endometrial hyperplasia (pro estrogenic there) |
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what is exemestane? side effects?
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- aromatase inhibitor (post menopausal breast cancer)
- menopausal symptoms = hot flashes, sweats, edema, DVT, endometrial hyperplasia (pro estrogenic there) |
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what is leuprolide?
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- LH-RH agonist (testicular & breast cancers), decreased LH & FSH = decreased testosterone & estrogen
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what is goserelin?
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- LH-RH agonist (testicular & breast cancers), decreased LH & FSH = decreased testosterone & estrogen
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what is methotrexate? where does it distribute? what is the form in cells? how is it excreted?
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- binds to DHFR, s phase specific
- 3rd spaces - polyglutamated in cells - renal excretion |
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what is leucovorin?
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- rescue drug for methotrexate
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what is cytarabine? how is it metabolized? what are some toxicities?
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- metabolized by deoxycytidine kinase (cytosine analog), S phase specific
- renally - b/c gets into brain can cause cerebellar toxicity, also ocular toxicity (chemical conjuncitivitis) |
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how does 5-FU work? what does leucovorin work with it?
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- fdUMP inhibits thymidylate synthase
- keeps it bound to TS more tightly |
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how does gemcitabine work?
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- activated by deoxycitidine kinase --> incorporated into DNA/RNA --> inhibits synthesis (cousin of cytarabine)
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what is dexrazoxane?
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- chelating agent used to decrease free radical formation w/ anthracyclines (doxorubicin) from causing cardiotoxicity
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how do irinotecan & topotecan work?
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- topoisomerase I inhibitors, G2 phase specific
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how do vincristin, vinblastine, vinorebine work?
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- MT inhibitors, m phase specific
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how to paclitaxel & docetaxel work?
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- taxanes, enhance MT polmerization & inhibit disassembly, m phase specific
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what is chlorambucil?
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- nitrogen mustard alkylator, used in treatment of CLL
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what is melphalan?
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- nitrogen mustard alkylator, used in treatment of MM (M&P)
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what is dacarbazine?
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- triazene alkylator
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what is hydroxyurea?
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- antimetabolite/analog
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what is fludarabine?
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- purine analog, used in treatment of CLL
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what is raloxifene?
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- anti-estrogen like tamoxifen
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what is dalteparin?
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- LWMH
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what is aminocaproic acid?
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- anti-fibrinolytic
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what is romiplostim?
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- thrombopoietin mimetic (TPO)
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what is eltrombopag?
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- thrombopoietin mimetic (TPO)
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what is diphenhydramine?
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- used to treat exrapyramidal movement associated w/ dopamine antagonists
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what is protamine sulfate?
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- use to treat overdose w/ heparin
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what is RhoGAM?
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- used to treat hemolytic disease of the newborn --> suppresses mom --> sensitizes mom to Rh+
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what is thalidomide?
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- anti-anigiotenic, but stops osteoclasts & MM cells from talking in MM
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what is lenalidomide?
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- oral thalidomide used in MM
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what is bortezomib?
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- proteasome inhibitor used in MM
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what is rituximab?
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- anti-CD20
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what is trastuzumab (herceptin)?
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- anti-HER2 used in breast cancer
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what is bevacizumab?
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- anti-VEGF
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what is cetuximab?
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- anti-EGFR
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what is imatinib (gleevac)?
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- BCR-ABL inhibitor (tyrosine kinase inhibitor) --> t(9;22) for philadelphia chromosome in CML
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what is erlotinib?
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- EGFR (tyrosine kinase) inhibitor (intracellular as opposed to cetuximab which is extracellular)
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what is azacytidine?
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- demethylating agent
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what is decitabine?
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- demethylating agent
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