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14 Cards in this Set
- Front
- Back
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Describe the blood picture you might expect to see in a patient with iron deficiency anemia.
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microcytic, hypochromic with anisocytosis and poikilocytosis
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How would you characterize iron levels in a patient with iron deficiency anemia?
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Decreased serum iron. Increased TIBC. Decreased iron stores and decreased sideroblasts in bone marrow.
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Describe the etiology of sideroblastic anemia.
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Abnormal heme synthesis resulting in abnormal iron deposition in mitochondria. Inherited (sex-linked or autosomal) or acquired (idiopathic, lead, alcohol, drugs).
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What abnormal RBC inclusion would you expect to observe in the peripheral blood of a patient with sideroblastic anemia?
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Basophilic stippling
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What cell type would you expect to observe increased numbers in the bone marrow?
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Ringed sideroblasts
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What is the M:E ratio range for a patient with megaloblastic anemia and what is the ratio normally?
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1:1 to 1:3. Normal M:E ratio is 4:1.
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Name the stages of megalogblastic erythrocyte maturation.
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Promegaloblast, basophilic megaloblast, polychromatophilic megaloblast, orthochromatic megaloblast, diffusely basophilc macrocyte, macrocyte.
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Describe the RBC indices of a patient with megaloblastic anemia.
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MCV greater than 100 fL. MCH increased. MCHC normal.
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Describe the blood picture for a patient with megaloblastic anemia.
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Macrocytic, normochromic, anisocytosis and poikilocytosis, decreased retics, RBC inclusions.
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Characterize the bone marrow in terms of cellularity for a patient with megaloblastic anemia.
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Hypercellular.
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List the methods of laboratory differential diagnosis of Vit. B12 and folic acid deficiencies.
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Serum B12 levels, serum and RBC folate levels, antibodies to intrinsic factor, Schilling's test to evaluate B12 absorption form GI tract.
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Describe the clinical features associated with hemolysis.
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Decreased RBC count, accelerated Hgb breakdown, increased bilirubin, decreased haptoglobin, hemosiderin in kidney tubules, increased urobilinogen in urine and feces, Hgb in urine.
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How might the bone marrow respond to hemolysis.
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Erythroid hyperplasia. In the peripheral blood: NRBC, increased retics, Howell-Jolly bodies.
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Name the main intracorpuscular defects of RBC membrane.
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Hereditary spherocytosis, hereditary xerocytosis, hereditary stomatocytosis, hereditary elliptocytosis.
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