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14 Cards in this Set

  • Front
  • Back
Describe the blood picture you might expect to see in a patient with iron deficiency anemia.
microcytic, hypochromic with anisocytosis and poikilocytosis
How would you characterize iron levels in a patient with iron deficiency anemia?
Decreased serum iron. Increased TIBC. Decreased iron stores and decreased sideroblasts in bone marrow.
Describe the etiology of sideroblastic anemia.
Abnormal heme synthesis resulting in abnormal iron deposition in mitochondria. Inherited (sex-linked or autosomal) or acquired (idiopathic, lead, alcohol, drugs).
What abnormal RBC inclusion would you expect to observe in the peripheral blood of a patient with sideroblastic anemia?
Basophilic stippling
What cell type would you expect to observe increased numbers in the bone marrow?
Ringed sideroblasts
What is the M:E ratio range for a patient with megaloblastic anemia and what is the ratio normally?
1:1 to 1:3. Normal M:E ratio is 4:1.
Name the stages of megalogblastic erythrocyte maturation.
Promegaloblast, basophilic megaloblast, polychromatophilic megaloblast, orthochromatic megaloblast, diffusely basophilc macrocyte, macrocyte.
Describe the RBC indices of a patient with megaloblastic anemia.
MCV greater than 100 fL. MCH increased. MCHC normal.
Describe the blood picture for a patient with megaloblastic anemia.
Macrocytic, normochromic, anisocytosis and poikilocytosis, decreased retics, RBC inclusions.
Characterize the bone marrow in terms of cellularity for a patient with megaloblastic anemia.
List the methods of laboratory differential diagnosis of Vit. B12 and folic acid deficiencies.
Serum B12 levels, serum and RBC folate levels, antibodies to intrinsic factor, Schilling's test to evaluate B12 absorption form GI tract.
Describe the clinical features associated with hemolysis.
Decreased RBC count, accelerated Hgb breakdown, increased bilirubin, decreased haptoglobin, hemosiderin in kidney tubules, increased urobilinogen in urine and feces, Hgb in urine.
How might the bone marrow respond to hemolysis.
Erythroid hyperplasia. In the peripheral blood: NRBC, increased retics, Howell-Jolly bodies.
Name the main intracorpuscular defects of RBC membrane.
Hereditary spherocytosis, hereditary xerocytosis, hereditary stomatocytosis, hereditary elliptocytosis.