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120 Cards in this Set

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decrease haptoglobin and increased serum LDH indicate RCB _________.
RBC hemoloysis
Decrease TIBC, increase ferritin, Increased storage iron in marrow macrophages
anemia of chronic disease
increased TIBC, decreased ferritin and decreased serum iron
iron deficiency anemia
______ cells are involved in type I hypersensitivity reactions.
Mast cells

bind IgE to membrane

found in tissue
cells that are highly phagocytic for antigen-antibody complexes.
eosinophils
Causes fo eosinophilia (NAACP)
Neoplastic
Asthma
Allergic processes
Collagen vascular diseases
Parasites
Large, spherical azurophilic primary granules are called
lysosomes

contain hydrolytic enzymes, lysozyme, myeloperoxidase, and lactoferrin
hypersegment polys are seen in ______ and ______ deficiency.
Vitamin B12 and folate deficiency.
B lymph have CD__ and CD___
CD19 and CD20
B cells can function as APC via _______ __.
MCH II

when antigen is encountered, B cells differentiate into plasma cells and produce antibodies
_____ ______ is a plasma cell neoplasm
multiple myeloma
Which of the following is necessary for endogenous activation of plasminogen
tissue plasminogen activator (tPA)
The FAB designation associated with a monocytic leukemia characterized by the presence of monoblasts, promonocytes and monocytes is
M5
measures the conversion of fibrinogn to fibrin after the addition of excess thrombin to undiluted plasma.
thrombin time

prolonged thrombin time=heparin contamination
Abnormal platelet function is the suspected cause of the bleeding problem in a patient who has a normal platelet count. What laboratory procedure provides information that would aid in discovering the cause of the bleeding problem?
bleeding time
A cellulose acetate electrophoresis revealed a large band of hemoglobin in the hemoglobin S position. This band quantified as 95%. The peripheral smear revealed 70% target cells and the solubility test was negative. This hemoglobin can be classified as
Hemoglobin D
Naphthol AS-D chloroacetate esterase is usually positive in ______ cells and alpha-naphthyl acetate esterase is useful for identifying blast cells of ______ lineage.
granulocytic; monocytic
Blue cytomplasmic inclusions in the neutrophiuls and giant platelets are present on a patient's blood smear. You would suspect the presence of
May-Hegglin anomaly
An adult patient with massive splenomegaly has mild anemia, a slightly elevated WBC and an LAP score of 170. The blood smear shows teardrop erythrocytes and leukoerythroblastosis. A bone marrow aspiate was attempted but was a "dry tap". Thes findings are most consistent with
An adult patient with massive splenomegaly has mild anemia, a slightly elevated WBC and an LAP score of 170. The blood smear shows teardrop erythrocytes and leukoerythroblastosis. A bone marrow aspiate was attempted but was a "dry tap". Thes findings are most consistent with
The presence of CD2. CD5, CD7 and the absence of CD 10 (CALLA) are associated with
T-cell acute lymphocytic leukemia
A young child is admitted to the hospital with chronic steatorrhea. Upon testing, it is noted that the child has a coagulation problem due to a vitamin deficiency. Which clotting factor would this deficiency affect?
factors II, VII, IX, X
The Philadelphia chromosome is associated with
CML

chronic granulocytic leukemia
Which of the following red cell morphology is characteristically seen in abetalipoproteinemia?
acanthocytes
Auer rods are composed of fused ________ granules
primary
Appropriate screening test for detecting hemoglobin F:
Kleihauer-Betke
Appropriate screening test for hemoglobin H is:
Heat instability test
The most appropriate sreening test for hemoglobin S is:
dithionite solubility
The most appropriate screening test for hereditary spherocytosis is:
osmotic fragility
Te most appropriate screening test for paroxysmal nocturnal hemoglobinuria is:
sucrose hemolysis test
thalassemias are characterized by:
decreased rate of globin synthesis
all staes of neutrophils are most likely to be seen in the peripheral bloof of a patient w/:
chronic granuloctic leukemia
serum iron is decreased, transferrin saturation is decreased, TIBC is normal or decreased in what condition:
anemia of a chronic disorder
hemorrhage in polycythemia vera is the result of abnormal ________ function
abnormal platelet function
In chronic myelocytic leukemia, blood histamine concentrations tend to reflect the number of _____ present.
basophils
hemolysis in paroxysmal nocturnal hemoglobinuria is caused by a ____ _____ _____ defect.
red cell membrane defect
in order for hemoglobin to combine reversibly w/ O2, the iron must be in the _____ state.
ferrous
the genetic defect in thalassemia usually results in a quantitative deficiency in RNA resulting in decreased _______ _____ production
decreased globin chain production
Hemoglobin H disease results from absence of ___ of 4 alpha genes.
3 of 4 alpha genese
What is associated w/ May-Hegglin anomaly?
Dohle bodies and giant platelets
What is associated w/ Chediak-Higashi syndrome:
membrane defect of lysosomes
all stages of neutrophils are most likely to be seen in the peripheral bloof of a patient w/:
chronic granuloctic leukemia
serum iron is decreased, transferrin saturation is decreased, TIBC is normal or decreased in what condition:
anemia of a chronic disorder
hemorrhage in polycythemia vera is the result of abnormal ________ function
abnormal platelet function
In chronic myelocytic leukemia, blood histamine concentrations tend to reflect the number of _____ present.
basophils
hemolysis in paroxysmal nocturnal hemoglobinuria is caused by a ____ _____ _____ defect.
red cell membrane defect
in order for hemoglobin to combine reversibly w/ O2, the iron must be in the _____ state.
ferrous
the genetic defect in thalassemia usually results in a quantitative deficiency in RNA resulting in decreased _______ _____ production
decreased globin chain production
Hemoglobin H disease results from absence of ___ of 4 alpha genes.
3 of 4 alpha genes
What is associated w/ May-Hegglin anomaly?
Dohle bodies and giant platelets
What is associated w/ Chediak-Higashi syndrome:
membrane defect of lysosomes
normal PT time and a prolonged PTT time. THe PTT corrects ot nromal when the incubation time is increased.
Fletcher factor deficiency (prekallikrein)
Acute DIC is characterized by:
hypofibrinogenemia
Coag factors affected by coumadin are:
II, VII, IX, X
Factor ___ differentiates sever liver disease & accompanying secondary fibrinolysis from DIC.
Factor VIII activity
lab findings associated with Factor XIII deficiency?
clot solubility in a 5 Molar urea solution
a hemophiliac male and a normal female can produce:
a female carrier
most common cause of abnomality in hemostasis?
quantitative abnormality of platelets
CML can transition into _____
ALL
classic von Willebrand's disease shows a decreased platelet aggregation to ________
ristocetin
The majority of iron in an adult is found as a constituent of ______.
hemoglobin
platelet satellitosis is usually due to ______
abnormal proteins
irregular clumping of platelets is usuallly due to:
inadequate mixing of blood and anticoag
when platelets concentrate at feathered end and edges of smear, it is usually due to a:
poorly made wedge smear
erythropoietin acts to stmulate _______ synthesis of erythroid cells
RNA synthesis of erythroid cells.
secondary granules of the neutrophilic granulocyte appear first at the ______ stage.
myelocyte stage
elevation of the total granulocyte count above 9 x 10 3/ul is termed:
absolute neutrophilic leukocytosis
elevation of the total white cell count above 12x 10 9/ul is termed:
leukocytosis
elevation of lymph % above 47% is termed:
relative lymphocytosis
election of the granulocyte percentage above 75% IS TERMED:
relative neutrophilic leukocytosis
Decreaed or absent bone marrow iron stores is characteristics of _______ ______.
polycythemia vera
thrombocytopenia is a characteristic of _____ _____ _______.
May-Hegglin anomaly
If prolonged PTT is corrected w/ fresh normal plasma, adsorbed plasma, and aged serum it is most likely a deficiency o f ?
Factor XI
The abnormal PTT was corrected by normal and adsorbed plasma, but not aged serum?
Facor V
vacuolated cytoplasm containing sphingomyelin and is faintly PAS positive. This cell type is most characteristic of:
niemann-Pick disease
clumped plateles may interfere w/ the:
WBC count
cold agglutinin results in an ______ MCV and _____ RBC/
increased MCV and decreased RBC
Blood in EDTA undgergoes what changes if kept at room temperature?
increased hematocrit and MCV
Glanzmann's thrombasthenia is associated w/ absence of _____ __________.
clot retraction
the bone marrow in the terminal stage of erythroleukemis is often indistinguishable from _________.
AML
Significant feature of erythroleukemia (Di Guglielmo's syndrome)?
megaloblastoid erythropoiesis
teardrop cells and abnormal platelets most characteristically seen in what diease state?
myeloid metaplasia
most useful differentiating hemophilias A and B?
mixing studies
membrane of RBC contains the _____-___________ antiport.
chloride-bicarbonate

allows the RBC to transport CO2 from the periphery to the lungs for elimination.
CD3 marks ____
T lymphocytes
Protein C and Protein S inactivates what two factors?
Va and VIIIa

vitamin K dependant
Antithrombin III inactivates what?
thrombin, IXa, Xa, and Xia

activated by heparin
tPA generates ______.
plasmin, which cleaves fibrin
CEA is a tumor marker found in :
colorectal and pancreatic cancers

also produced by gastic & breast cancer

carcinoembryonic antigen
a-fetoprotein is a tumor marker of:
hepatocellular carcinomas

tumors of the testis
target cells are commonly found in what 4 conditions:
HbC disease, Asplenia, Liver disease, thalassemia
burr cells are seen in what 2 conditions:
HUS/TTP
vitamin B12 deficiency is associated with ______ problems unlke folate deficiency.
neurologic
decrease serum iron, increased TIBC, and decreased ferritin is associated with:
iron deficiency
decreased TIBC, increased ferritin, and increase storage iron in marrow macrophages indicates what condition?
Anemia of chronic disease
decrease serum haptoglobin and increase serum LDH indicatd:
RBC hemoloysis
Sickle cell anemia is a single amino acid replacement in the ____ chain.
Beta chain

substitution of normal glutamic acid with valine
substitution of a lysine residue for glutamic acid residue at the 6th position of the ß-globin chain results in:
hemoglobin C disease
In B-thalassemia major the B chain is _____.
B-chain is absent

fetal hemoglobin in compensatorily increased but inadequate
In B-thalassemia minor the B chain is __________.
B-chain is underproduced

fetal hemoglobin in compensatorily increased but inadequate
In a-thalassemia, the a-globin chain is _________.
underproduced

there is NO compsensatory increase of any other chains.
________ lacks 3 alpha-globin genes, B4-tetramers.
HgH
_______ lacks all 4 a-globin genes and results in hydrops fetalis & death.
Hb Barts
a-thalassemia is prevalent in _____ and _______.
Africa and Asia
b-thalassemia is prevalent in ___________.
Mediterranean populations
Increased serum bilirubin and increased reticulocytes are seen in ______ anemia.
hemolytic anemia
Autoimmune hemolytic anemias are _______ positive.
DAT

direct Coombs' positive
Herediatry spherocytosis is due to a ____ or ______ defect.
spectrin or ankyrin

increased MCHC and RDW

osmotic fragility test to confirm
autoimmune anemia is mostly _________ hemolysis.
extravascular hemolysis

accelerated RBC destruction in liver Kupffer cells and spleen.
PNH causes _______ hemolysis.
intravascular hemolysis

increased sensitivity of RBC to lytic activity of complement
Paroxysmal nocturnal hemoglobinuria results in increased urine ________.
hemosiderin
increased PPT, PT, fibrin split products (D-dimers), decreased platelet counts all indicate what condition:
DIC

activation of coag cascade leading to microthrombi nd global consumption of platelets, fibrin, and coag factors.

helmet cells and schistocytes on blood smear
Extrinsic coag pathway monitors factors ___,___,____, and ____.
2, 5, 7, and 10

PT
Glanzmann's thrombasthenia is a defect of platelet ___________.
platelet aggregation

Decreased GP IIb-IIIa
Bernard-Soulier disease is a defect of platelet _________.
platelet adhesion

decreased GP Ib
Reed-Sternberg cells are seen in __________ disease.
Hodgkin's disease
older adults;lymphadenopathy; hepatosplenomegaly;few symptoms; indolent course; increase of smudge cells in peripheral smear:
CLL
Philadelphia chromosome (t9:22),bcr-abl)myeloid stem cell proliferation; presents w/ increased neutrophils and metamyelocytes; splenomegaly; may accelerate to AML; very low LAP (leukocyte alkaline phosphatase) vs. leukemoid reaction.
CML
auer rods are peroxidase-positive cytoplasmic inclusions in _______ and ________.
granulocytes and myeloblasts

primarily seen in acute promyelocytic leukemia (M3)
heparin must be followed with ______ test.
PPT
warfarin must be following with _____ test
PT