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14 Cards in this Set
- Front
- Back
Describe the lineage of a mature RBC and discuss other paths hematopoietic stem cells can go. Also mention specific cytokines involved
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Describe erythropoiesis
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What does a reticulocyte look like?
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Describe the regulation of erythropoiesis.
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1. EPO is a glycoprotein in the kidney that is stimulated by low O2 saturation
2. EPO stimulates proliferation of BFU-E and CFU-E, also accelerates bone marrow erythroid proliferation, and Hb formation and Fe utilization |
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What are the 4 essential requirements of RBC production?
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1. Fe
2. AAs 3. Folic Acid 4. B12 (cobalamin) 5. B6 (pyridoxine) |
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Describe Fe transport
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What molecule acts as the storage form of insoluble iron?
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1. Hemosiderin
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Describe how Fe enters and leaves the duodenal cell.
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Describe the synthesis of hemoglobin.
**include heme synthesis and globin synthesis in general** |
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Describe how Hepcidin acts as a negative iron regulator
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Describe O2 dissociation curve and what effects it.
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Describe the basic structure of the RBC cytoskeleton.
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Contents
1. Ankyrin 2. Alpha and beta spectrin 3. Actin 4. Tropomyosin 5. Band 3 6. Adducin |
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What functions do ATP, NADH, 2,3-DPG, NADPH, and GSH contribute to RBC metabolism?
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1. ATP - energy
2. NADH - maintain reduced form of Fe 3. 2,3-DPG - enhance O2 release under low O2 tension 4. NADPH and GSH - removal of toxic oxidants and prevent denaturation of globin |
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Describe the recycling process of RBC components
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1. The protoporphyrin ring is broken releasing CO and FE (tetrapyrrole ring too)
2. Unconjugated bilirubin travels to the liver via albumin, then conjugated 3. conjugated bilirubin is converted to urobilinogen which is excreted in the stool or reabsorbed |