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48 Cards in this Set
- Front
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The following Results are obtained:PT: Normal , APTT: Prolonged; APTT withAds Plasma: Not Corrected. What is the deficient factor?
A. Antihemophilic Factor B. Plasma Thromboplastin component C. Stuart Prower Factor D. Hageman Factor |
B. Plasma Thromboplastin component |
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transient thrombocytopenia (HIT) is side effect of:
Protamine sulfate Heparin Warfarin Aspirin |
Heparin |
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In cellulose Acetate Electrophoresis, which of the following HGB variants willmigrate with Hgb A2?
A. Hgb S B. Hgb C C. Hgb F D. Hgb A |
B. Hgb C |
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Which of the following factors is not found in the serum? A. V C. X B. XI D. A and C |
A. V |
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Glanzmann Thrombasthenia will show a normal in vitro aggregation test result in which of the following stimulating agents? A. ADP B. Ristocetin C. Collagen D. Both A and B |
B. Ristocetin |
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What occurs during platelet Adhesion? A. Binding of GP IIb/ IIIa with Fibrinogen B. Shape change of Platelet C. Binding of GP ib with vWf D. Release of Thromboxane A2 |
C. Binding of GP ib with vWf |
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DIPYRIDAMOLE Mechanism of Action: Inhibiting the binding of fibrinogen to activated platelets Inhibiting cyclic nucleotide phosphodiesterase Blocking glycoprotein IIb/IIIa receptor Inhibiting cyclooxygenase |
Inhibiting cyclic nucleotide phosphodiesterase |
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Prolonged APTT, Prothrombin Time, and Bleeding Time is a result for which condition? A. Von Willebrand Disease B. Hemophilia B C. DIC D. All of the above |
C. DIC |
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Which of the following Organisms is a VIT K Producer? A. Orientia tsutsugamushi B. Bacteroides fragilis C. Proteus mirabillis D. B and C |
B. Bacteroides fragilis |
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Bernard Soulier Syndrome will result to a defect in which platelet function? A. Platelet Adhesion B. Platelet Secretion C. Platelet aggregation D. None |
A. Platelet Adhesion |
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Which of the following my be used to stain neutral fats, phospholipids and sterols? A. Peroxidase B. Sudan Black B C. PAS D.Prussian Blue |
B. Sudan Black B |
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A 5-year-old boy contracts fulminant hepatitis A from contaminated vegetables. He is hospitalized in the intensive care unit with hepatic failure and hepato-renal syndrome necessitating dialysis. The intensive care physician is planning on placing a dialysis catheter and orders a PT and aPTT. The PT is 56 seconds (normal range 9–12 seconds) and the aPTT is 99 seconds (normal range is 22–33 seconds). Which combination of factor deficiencies is most likely in this scenario? A. Factors II, V, VIII, and X B. Factors II, VII, VIII, and IX C. Factors II, VII, IX, and X D. Factors VII, VIII, IX, and XI E. Factors VII, VIII, IX, and von Willebrand factor |
C. Factors II, VII, IX, and X |
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Which of the following factor will be decreased in cases of Vitamin K deficiency? I. Christmas Factor II. Proconvertin III. Stuart Factor IV. Hageman Factor A. II and III B. I, II and III C. I and IV D. I, II and IV |
D. I, II and IV |
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In the positive pressure method for Capillary Fragility Test, which is being increased? A. Oncotic Pressure B. Hydrostatic Pressure C. Osmotic pressure D. Both B and C |
B. Hydrostatic Pressure |
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A 5 year old male presents with fulminant acute hepatic failure. He is noted to be bleeding from his gums, nose and has hematochezia. This patient’s bleeding is most likely due to which of the following combinations: A. Deficiency of fibrinogen, factor VII and factor II. B. Thrombocytopenia and factor XI deficiency. C. Factor VIII, IX and XI deficiency. D. Factor V and VIII deficiency. E. Low levels of von Willebrand factor and factor VIII. |
A. Deficiency of fibrinogen, factor VII and factor II. |
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A patient has a white blood count of 50 x 103/uL. To distinguish between bacterial infection and chronic granulocytic leukemia, the most useful test is? A. NBT Reduction B. TRAP C. PAS D. LAP |
A. NBT Reduction |
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A 6 year old girl requiring a adenoidectomy undergoes pre-operative laboratory testing by her surgeon revealing a prolonged activated partial thromboplastin time (PTT) of 150 seconds (normal range 22-36 seconds). Her prothrombin time (PT) is normal. She had previously had 2 dental extractions that were uneventful. She otherwise has no personal or family history of bleeding. Which of the following is most likely: A. Factor VIII activity of 2% B. Factor IX activity of 2% C. Factor VII activity of 2% D. Factor XI activity of 2% E. Factor XII activity of 2% |
E. Factor XII activity of 2% |
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A 10 day old male is being seen in the emergency room due lethargy and poor feeding. Her anterior fontanel is full. A CT scan demonstrates an intraparenchymal hemorrhage. Coagulation tests are ordered with the following results: PT—37 seconds (normal 9.7-11.2 seconds) and a PTT of 66 seconds (normal 22-36 seconds). This child may have which of the following factor deficiencies: A. Factor VII. B. Factor VIII. C. Factor IX. D. Factor X. E. Factor XI. |
D. Factor X. |
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Abnormal Increased activity of Inhibitors will result to which of the following? Bleeding Clotting Fibrinolysis All |
Bleeding |
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A 56 Year old woman was admitted to the hospital with a history of a moderate to severe bleeding tendency of several duration. APTT was said to be prolonged and PT was normal. Abnormal result was corrected with Aged serum and adsorbed plasma. Deficiency of which of the following is most likely? A. Factor X B. Factor VIII C. Factor XI D. Factor IX |
C. Factor XI |
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In case of Hemophilia B, which of the following tests would be prolonged? I. Clotting Time II. APTT III. PT IV. Reptilase Time A. I and II B. I, II and III C. II and IV D. I and IV |
A. I and II |
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Which of the following is secreted by the Alpha granules of the platelets? I. ADP II. Fibrinogen III. Serotonin IV. vWf A. I and III B. II and III C. I and II D. II and IV |
D. II and IV |
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A 3-year-old girl presents with prolonged oozing from her tongue after apparently biting it. Her platelet count is normal. Her PT is 68 seconds (normal range is 9–12 seconds), her aPTT is 123 seconds (normal range is 22–33 seconds) and her thrombin time is 58 seconds (normal range is 12–18 seconds). Which of the following tests should be ordered next? A. Factor XIII level B. Fibrinogen level C. Factor X level D. Ristocetin cofactor activity E. Prekallikrein level |
B. Fibrinogen level |
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"prevent progression of thrombosis" is the function of: Anticoagulatants Fibrinolytics Antiplatelets All of the above |
Anticoagulatants |
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Which of the following tests can be useful in differentiating leukemoid reactions from chronic granulocytic leukemias? A. Peroxidase stain B. Specific esterase Stain C. Sudan Black B stain D. Leukocyte Alkaline Phosphatase |
D. Leukocyte Alkaline Phosphatase |
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You are seeing a 10 year boy old with easy bruising and recurrent epistaxis as a second opinion. He is active in a variety of sports, however his mother feels that his bruising is excessive. His pediatrician sent the following laboratory tests all of which are normal: WBC, Hemoglobin, platelet count, PT, PTT. Another hematologist ordered the following all of which were normal: VWF Ag, ristocetin cofactor activity, factor VIII activity, factor XIII activity, and platelet aggregation studies. Which of the following physical exam findings would be most informative: A. Petechiae where the blood pressure cuff was placed. B. Hypermobility of the finger joints. C. Palpable bruises over the tibial surface. D. A conjunctival hemorrhage E. Albinism. |
A. Petechiae where the bloodpressure cuff was placed. |
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Deficiency of Decay Accelerating Factor (DAF) on the cell membrane can cause a hemolytic Disorder that can be confirmed using which special Hematology Test? A. Kyurem Denaturation Test B. RivaltasTest C. Sucrose Hemolysis Test D. A and C Test |
C. Sucrose Hemolysis Test |
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Which of the following INCREASE ANTICOAGULANT EFFICACY? Hyperlipidemia Edema Hyperthyroidism Hypothyroidism |
Hyperthyroidism |
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ANTIPLATELET DRUGS except: FONDAPARINUX CLOPIDOGREL TIROFIBAN None |
FONDAPARINUX |
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kidney enzyme that directly converts plasminogen to active plasmin: Streptokinase Alteplase Urokinase Tenecteplase |
Urokinase |
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Kasabach Merritt Syndrome Is characterized by: A. Vasculitis caused by allergy with Complement containing IgA B. Collagen degradation due to Old age C. Hemangioma D. Missing Elastin |
C. Hemangioma |
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Rosenthal Syndrome will result to a prolonged result in: A. Clot Retraction B. Prothrombin Time C. APTT D. Both A and C |
C. APTT |
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A 1 year old male presents to the emergency room with irritability and vomiting, and a CT scan demonstrates a large intracranial parenchymal hemorrhage. The mother reports that his only other bleeding symptom was prolonged bleeding from the umbilical stump. The patient comes from a large pedigree with numerous male and female first and second degree relatives, however there is no history of excessive bleeding in any of them. Which of the laboratory test patterns are most consistent with this history? A. Normal PT and PTT. B. Prolonged PT, normal PTT. C. Normal PT, prolonged PTT. D. Prolonged PT, prolonged PTT. |
A. Normal PT and PTT. |
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Mechanism of Action of Warfarin, Except: inhibit epoxide hydrase
interfere with the synthesis of vitamin K and thus inhibits activation of vitamin K- dependent clotting factors (II, VII, IX, X)
also decreases the activity of protein S (activated by thrombin) – responsible for some side effect None |
also decreases the activity of protein S (activated by thrombin) – responsible for some side effect |
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An 11 year old female with recurrent tonsillitis is referred for a tonsillectomy. Her surgeon orders pre-operative laboratory tests and the results demonstrate a PT of 10.2 seconds (normal 9.7-11.2 seconds) and a PTT of 58 seconds (normal 22-36 seconds). The most appropriate next test to order is: A. Factor VIII activity. B. Factor IX activity. C. Factor XI activity. D. Factor XII activity. E. A mixing study. |
E. A mixing study. |
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The cell series most readily identified by a positive Sudan Black B is: A. Erythrocytic B. Myelocytic C. Lymphocytic D. Megakaryocytic |
B. Myelocytic |
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A 4-year-old male is in the intensive care unit and has been intubated and sedated. You are asked to consult because of the presence of numerous generalized petechiae and some large ecchymosis on the abdomen and trunk. Laboratory evaluation demonstrates a platelet count of 45 × 109/L, a PT of 15.4 seconds (normal 9.7–11.2 seconds), a PTT of 48 seconds (normal 22–36 seconds), and a fibrinogen level of 0.87 g/L (normal 2–4 g/L). Which of the following most likely led to these clinical findings? A. Immune thrombocytopenic purpura (ITP) B. Systemic lupus erythematosus (SLE) C. Congenital hypofibrinogenemia D. Acute promyelocytic leukemia E. Vitamin K deficiency |
D. Acute promyelocytic leukemia |
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Elevated APTT is observed in which of the following? I. DIC II. Parahemophilia III. XIII Deficiency IV. Thrombocytopenia A. I only B. I and II C. I, II and III D. I, II, III and IV |
C. I, II and III |
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In the Sodium Dithionite Test, which of the following component will Lyse the RBCs to release hgb? A. Atroxin C. Platelin D. Durex |
A. Atroxin |
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A 13-year-old girl develops menorrhagia at the onset of menarche requiring several packed red blood cell transfusions. She also required a transfusion after a tonsillectomy and adenoidectomy when she was 5 years old, but it was never evaluated. She also has easy bruising and gingival bleeding daily when she brushes her teeth. She is referred to you by her pediatrician for an evaluation. There is a history of menorrhagia in the mother though she never required any transfusions. In addition, there is a history of epistaxis and postsurgical bleeding in the father. Her parents have normal aPTTs and the patient has an abnormal screening laboratory test. Which of the following is the most likely diagnosis? A. Factor VII deficiency B. Factor VIII deficiency C. Factor IX deficiency D. Factor XII deficiency E. Factor XIII deficiency |
A. Factor VII deficiency |
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Scurvy is a vascular disorder characterized by inefficient collagen synthesis due to deficiency of which of the following? A. Folic Acid B. Ascorbic Acid C. Collagen synthetase D. Hyaluronic Acid |
B. Ascorbic Acid |
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A 44-year-old man in acute distress is noted to have multiple ecchymoses of the skin that have developed over the past 48 hours. His prothrombin time (PT) is 38 seconds and partial thromboplastin time (PTT) 55 seconds. A CBC shows a WBC count of 5300/microliter, hemoglobin 8.1 g/dL, hematocrit 24.9%, MCV 99 fL, and platelet count 16,300/microliter. His D-Dimer test is very high. Which of the following is the most likely diagnosis? A. Hemophilia A B. Afibrinogenemia C. Vitamin K deficiency D. vonWillebrand disease E. Disseminated intravascular coagulopathy |
E. Disseminated intravascularcoagulopathy |
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The positive Color for Non-Specific Esterase staining is: A. Gold B. Red C. Blue D. Purple |
B. Red |
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Which of the following is true regarding the bleeding time? A. It is a highly reliable and reproducible test B. The sample is evaluated using an optical densitometer C. It evaluates platelet function in vivo D. It is a commonly ordered test E. It evaluates the coagulation system |
C. It evaluates platelet function in vivo |
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Mode of Administration for Heparin: Intramuscular Intradermal Intravenous All of the above |
Intravenous |
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Acute Disseminated intravascular coagulation is characterized by: A. Hypofibrinoginemia B. Thrombocytosis C. Negative D-Dimer D. Shortened Prothrombin Time |
A. Hypofibrinoginemia |
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Which of the following is a characteristic of a normal inactive platelet? A. Appears gray in wright stained smears B. Multi nucleated C. Granular D. Spherical in shape |
C. Granular (Still unsure can be in shape still) |
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Singer Method of Alkaline Denaturation is a test to measure increased Level of: A. Hgb S C. Hgb F D. Hgb A |
C. Hgb F |
