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10 Cards in this Set

  • Front
  • Back
Heart failure
THERAPUTIC STRATEGIES
Diuretics
ACE inhibitors
beta blockers
Vasodilators
Digoxin- for chronic heart failur
beta 1 selective agonists
PDE inhibitors
Digoxin
תאור
Cardiac glycoside- steroid + lactone rind+ sugar residues
Block Na/K pump thus increase contractility and CO
Digoxin
effects
increase contractility and CO
Electrical effects: prolong PR- slow ventricular rate
Shorten QT, invert T, ST depression
Digoxin
Toxicity
Increased automaticity due to Ca overload- PVB- Bigeminy
chronic:arrhythmias(thaccicardia and fibrilation), nausea, vomiting, diarrhea
acute intoxication (suiiccied) will result in cardiac depression and arrest.
Treatment: תיקון מדדי הפוטסיום והמגנזיום in chronic case. in the acute case there is usually hyperkalemia so no k.
antiarrhythmic drugs
digoxin antibodies - digibind
beta 1 selective agonists
Dobutamine
Dopamine
given in acute heart failure
beta blockers
carvediol
metoprolol
בטיפול במצב כרוני ובבעלי לב מוגדל
PDE inhibitors
theophilline
Amrinonr
Milrinon
אותו אפקט כמו לבטה אגוניסט
Vasodilators
acute: Nitroprusside
Nitroglycerin
chronic: Hydralazine
Isosorbide dinitrate
Diuretics
Furosemide
Tiazide
K sparring
ACE inhibitors
Captopril
Losartan