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30 Cards in this Set
- Front
- Back
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What are the 4 types of Heachaches?
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Tension HA
Sinus Cluster Migraine |
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Unilateral, severe, restless during attack, ipsi symptoms, lasts 15-180 min.?
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Cluster HAs
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Bilateral, band like, may have photophobia, lasts minutes to days?
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Tension HAs
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60% bilateral, pulsating, worse w/physical activity, nausea, photophobia, lasts 4-72 hours?
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Migraines
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What are the 4 areas sensitive to pain w/ a HA? (trauma is most likely cause)
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1. Fold of dura btwn hemispheres
2. MMA of the dura 3. dural venous sinuses 4. extraparenchymal region of larger pial arteries |
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Pain at the front of the head has what innervation?
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branches of Trigeminal N---TrigmeninoThalamic pain circuit
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Pain at the back of the head has what innervation?
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branches of 1st 3 cervical spinal nerves---CervicoThalamic Pain circuit
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What are some Migraine triggers?
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Vasodilators- alcohol, Na Nitrates
Vasoconstrictors- caffeine, tyramine MSG Artifical sweeteners |
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What vitamins might be helpful for migraines?
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B2/B6 vitamins
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between ages 40-60, more common in women, cocaine use?
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Thunderclap HA
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Aura w/vasoconstriction releases serotonin----it will go on to trigger _____________.
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Trigeminal N---which will vasodilate and release peptides that cause pain
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Serotonin is made from _______________.
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Tryptophan
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How is Serotonin terminated?
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reuptake and MAOb
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What serotonin receptor is in the CNS and BVs and changes cAMP levels?
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5HT1
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What serotonin receptor is in the CNS and BVs and changes IP3 and DAG activity?
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5HT2
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What serotonin receptor is in the peripheral nervous system?
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5HT3
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What serotonin receptor is in the enteric nervous system?
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5HT4
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What is a 5HT 1B/1 D agonists?
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Triptans
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Why is it important to use HA medicines fast?
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to prevent central sensitization
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What are responsible for controlling dilating BV's with a migraine?
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Astrocytes
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Forward control of blood and plays a role in peptide release?
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the balance of PROSTAGLANDINS
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What is the first line for Cluster HAs?
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Triptans (Sumatriptan)
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What do you give for an acute Cluster HA?
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100% O2
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HA meds overuse:
Ergotamines or Triptans- Opioids & combo analgesics- Simple Analgesics- |
>10 days for >3 months
>10 days for > 3 months >15 days for > 3 months |
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What is the treatment for Neuralgia? "Tic Douloureaux"
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Carbamazepine
Gabapentin |
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Avoid Triptans within ____________weeks of MAO Inhibitor usage.
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2 weeks
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Avoid 5HT1 agonist triptans in what?
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coronary heart disease
peripheral vascular dx uncontrolled hypertension complex migraine |
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What is essential for converting Tryptophans to Serotonin?
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B6
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What is the precursor to key molecules in the ETC?
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B2- Riboflavin
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What is an agonist of 5HT2a receptor?
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LSD
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