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5 Cards in this Set
- Front
- Back
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Neisseria meningitides characteristics
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i. Gram negative
ii. Non-motile iii. Capsulated iv. Diplococci v. Fastidious vi. Oxidase positive vii. Maltose/glucose fermentation |
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N. meningitides epidemiology
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i. Humans only known host
ii. Transmitted by respiratory droplets and prolonged close contact |
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N. meningitides virulence
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i. Capsule
ii. LOS→antigenic variability, intense immune response iii. PorA/PorB iv. Pili |
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Lipooligosaccharide
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i. Related to LPS but lacks O-antigen
ii. Morbidity/mortality correlates with circulating blood LOS levels |
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Pathogenesis of n. meningitides
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i. From URT, internalized by non-ciliated epithelial mucosal cells
ii. Enter the submucosa and subsequently in the bloodstream |
