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22 Cards in this Set
- Front
- Back
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2 characteristics of stomach mucosa
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deep tan color of simple columnar
rugae (folds of mucosa/submucosa) |
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Epithelium of stomach
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simple columnar w/ gastric pits (foveola)
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two regions of gastric pits
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superficial (foveolar compartment)
deep (glandular compartment) |
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2 main cell types of glandular compartment in fundus
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parietal cells (pink)
chief cells (blue) |
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In the cardia, what cells make up the glandular compartment?
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mucous cells (simple columnar)
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Difference between cardia and antrum.
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antrum has straight, long pits (anchored)
cardia has curved pits |
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Where does H.pylori collect?
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where urea levels are highest
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Where and which layer does H/ pylori live?
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gastric foveolar cells, not intestinal
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What does H.pylori use to degrade the mucus barrier?
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proteases, causing indirect epithelial injury
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What two products can injure cells in exposed tissue?
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ammonia, cytotoxins
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4 outcomes from H.pylori
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acute inflammation (gastritis)
chronic inflammation (gastritis) necrosis (peptic ulcer dz) chronic inflammation (gastric lymphomas, gastric adenoCA) |
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Stain for H.pylori
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silver stain
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etiologies of acute inflammation of acute gastritis?
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drugs (NSAIDs, ETOH, CA chemo)
infection (H.pylori) complication of other dz mucosal hypoxia (shock, trauma, burn, surgery) |
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2 main pathologic changes in acute gastritis?
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direct injury of mucosa
interferes w/ normal protective mech |
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3 levels of acute gastritis
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inflammation
necrosis->erosion erosion w/ hemorrhage |
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3 path images
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acute inflammation
patchy mucosal necrosis petechial hemorrhage |
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outcomes of chronic inflammatory cells
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epithelial necrosis
-> necrosis ->intestinal metaplasia, dysplasia, cx |
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Indicator of intestinal metaplasia in stomach
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brush border (2 cell types)
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Autoimmune chronic gastritis pathogenesis
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AD inheritance
autoAb to parietal cell (IF, enzymes, in fundus/body) leads to gland atrophy |
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3 main etiologies of Peptic ulcer dz
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H.pylori
NSAIDs inc gastric acid (Zollinger-Ellison) these combined w/ acid/pepsin leads to epithelial necrosis |
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4 regions of ulcer
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fibrinopurulent exudate
necrotic tissue granulation tissue fibrotic tissue/scar |
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3 complications of peptic ulcer dz
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hemorrhage
perforation obstruction |
