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23 Cards in this Set

  • Front
  • Back
characteristics of COX
complex structure
tiny amounts in body
hard to purify
unstable (t 1/2 = seconds)
eichosonoid hormone characteristics
"1 pass effectors"
paracrine (not endocrine)
made on spot
quick action then gone
functions of eichosonoids
inflammation
reproduction (RU 486 & PGE2)
inhibit HCL secretion
BP regulation
BF to kidney (increase GFR for elderly)
clotting
-TXA2 & PGE2
-PGI2 (cyclin) inhibits
ductus arteriosis
-indometh closes
-PGE2 keeps open
stearic acid
C18:0
arachadonic acid
C20:4
hairpin structure
head/tail association
resembles prostanoic acid
(parent structure for PGs)
families of prostaglandins
PGA (most oxidized)
PGE
PGF (most reduced)
common characteristics of PGs
2 double bonds (delta 5)
-after 5 & 13

C 15 hydroxyl
synthesis of arachadonic acid
from linoleic
ACoA synthetase
delta 6 desaturase
elongase
delta 5 desaturase
arachidonoyl CoA
ACoA synthetase
gives linoleoyl CoA (from linoleic)
uses ATP
desaturase always moves toward
carboxyl end
by count of 3
Elongase always...
lengthen chain by 2
forms malonyl CoA
blows off CO2
always at carboxyl end
COX 1
gastric mucosa
constituatively active
renal BF
plts, vasc endo, kidney
COX 2
MPs, monocytes, sm muscle
inducible
-PAF, LPS (bugs), IL-1
regulation of COX
many levels
substrate avail
induction of COX2
NSAIDs
annexin
ANX 1

-blocks PLA2
-binds lipids (cell membrane)
-glucocorticoids induce ANX1
reservoir for arachadonic acid
phosphotidylinositol
(aa would detergent & inhibit enzymes)
rate limiting step of eichosonoid synth
PLA2
releases arachadonic acid
(from phosphotydilinositol)
inhibited by ANX1
COX reaction
O2 straddles ring
"bisdioxygenation"
gives PGG2
PGG2
intermediate in COX pathway
NOT eichosonoid
hydroperoxidase
takes PGG2 to PGH2
uses GSH to GSSG
isomerases determine fate
unique structure in eichosonoids
TXA2-
"weird O in middle of ring"
aspirin effect on eichoso's
covalent modifier of COX
via serine in pocket
non-aspirin NSAID effect on eichoso's
covers mouth of serine pocket (active site)