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43 Cards in this Set

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Describe Sexual Reproduction and what it requires.

Requires the fusion of gametes and these gametes must undergo reduction division.

What are Germ-Line Cells?

Cells that will become gametes

What are Somatic Cells?

All other cells in a multi-organism

Where does meiosis occur?

Only occurs in germline-cells.

Meiosis 1, give the steps

Prophase 1, Metaphase 1, anaphase 1, telophase 1

What occurs in Prophase 1?

1.DNA condenses


2.Nuclear envelope disintegrates


3.Spindle Fibers Form


4.SYNAPSIS-homologous chromosomes pair up base pair to base pair


5.Crossing over and Recombination occurs - Important for genetic diversity and sister chromatids are now identical.

What occurs in metaphase 1?

1. Chromosome pairs are now at the center of the cell.


2. Line up in random orientation another source of genetic diversity.

What occurs in Anaphase 1?

1. Homologous chromosomes separate


2. chromosomes moves to opposite poles.



What occurs in Telophase 1?

1.Homologous chromosomes have moved to opposite poles.


2. Nuclear membrane reforms


3. Cytokinesis may occur

Name the steps in Meiosis 2.

Prophase 2


Metaphase 2


Anapphase 2


Telophase 2



What occurs in prophase 2?

Everything that happens in mitosis occurs in meiosis 2.

What is Cohesin?

-It is a protein that holds sister chromatids together


-Breaks down in metaphase in meiosis 2 and mitosis to allow them to separate.


* Doesn't occur in meiosis 1 because it is protected by Shugoshin

Making Sperm; where does it occur and name each cell name along the way.

Occurs in the testis




Germ cell --> Primary spermatocyte (Mitosis)


Primary spermatocyte --> Secondary (Meiosis 1)


Secondary --> Spermatids (Meiosis 2)


Spermatids --> sperm (gets a tail and ditches most of cytoplasm)



Producing Eggs; Where does it occur and name each cell type along the way.

Occurs in the ovaries




Germ Cells --> Primary oocyte (Mitosis)


Primary oocyte --> Secondary (Meiosis 1)


Secondary --> Egg + polar body (Meiosis 2)



What are polar bodies?

Eggs are built for nourishment, so the cytoplasm will divide unequally giving the egg the majority of the cytoplasm after each division.

Female Facts needed to know

-Meiosis 1 begins 2-3 months after gestation


-Females born with all primary oocytes


-one oocyte per mestrual cycle after completion of meiosis 1


-Only goes to meiosis 2 if fertilized





Embryos during the 1st 8 weeks, what happens?

-Electrical charge on oocyte surface prevents other sperm from penetrating


-2 nuclei fuse and form a zygote


-Cleavage begins


- Implantation occurs ~1 week after fertilization and human chorionic gonadotropin is secreted

What is a Genotype?

The genetic makeup of an organism

What is a phenotype?

Observable properties of an organism. This is the product of the genotype and the environment.

What is a Gene?

It is the fundamental unit of heredity, an inherited factor that dictates a particular trait.

What is an Allele?

Different forms of a gene, individuals may be heterozygous or homozygous.

What is a Locus?

Physical location on chromosome where a gene is located.

Morphological vs molecular phenotypes.

Morphological can be seen, ie. eye color.


Molecular, why are eyes blue and green? How do brown eyes differ from blue molecularly?

Who was Gregor Mendel?

-Austrian Monk


-Studied at the University of Vienna


-Studied Pisum Sativum (peas)


-Reported studies in 1865 and were ignored until 1900's.

What are "true breeding" plants?

Plants that are homozygous.



What are monohybrid crosses?

-Performed by Mendel


-Parents only differ in one trait.


-Consists of a P generation, F1, F2 F3, F4, ... Fx


-Parent generation to first filial and so on.




Mendel found that no difference in F1, but F2 a recessive trait appeared.

What are Mendels Four Postulates?

1. Genetic traits are controlled by factors (genes) that exist in pairs within individual organisms.


2. When a pair consists of different forms, one factor is dominant to the other.


3. During gamete formation, the paired factors separate randomly into gametes.


4. Independent Assortment; during gamete formation pairs of factors assort independently of each other.

Know how to do punnett squares!!!

Seriously.

What is a test cross?

When there is a cross with a known homozygous recessive subject.




RrYY x rryy

What is a dihybrid cross?

When there are two genotypes crossed at the same time.



RRYY x RrYy



Know how to do branch crosses!

They're simple faster...seriously

What is probability?

Prob=1 event is certain


Prob=0 event is impossible




Prob = # of favorable cases / # of possible cases

What is the addition rule?

The probability of either one of two independent, mutually exclusive events, occurs is the sum of their individual probabilities.




"Either Or"




Roll a die 4 or 6? = 2/6

What is the multiplication rule?

It is the probability of 2 independent events occurring simultaneously. When one result has no influence on the second result.




"And"




Roll a 6 and then a 4? = 1/36

Chi Square analysis Chart

Obtained -- Expected -- (o-e)^2 --- (o-e)^2/e

What does Degrees of Freedom equal?

N-1




tomato color. Red, yellow, orange, green




d.f=3

What is Codominance?

Both phenotypes are expressed.




For example, ABO blood system in humans




A type, B type, AB type, and O type

What is incomplete dominance?

-Phenotype of heterozygote is somewhere in between that of either homozygote




- Chickens, Black chicken + White Chicken = blue/grey chicken.

What is penetrance of a gene?

Probability that a disease phenotype will appear if the genotype is present.




For example, One parent has a bad recessive gene. If this gene is present, even if recessive, it can penetrate and become expressed.

What is expressivity of a gene?

The range of phenotypes with a given genotype.


Meaning, how severe is the trait? Can be seen with autism and other mental illnesses.

What is epistasis?

Greek word meaning "standing above"


Occurs when 1 gene masks the effects of another.




to find look for a variation in 9:3:3:1




Black Lab, Chocolate Lab, Yellow Lab

What are Lethals?

Cause breeding to now be true.


For example, Yellow Mice...




YY=Dead


Yy=Yellow


yy=non-yellow




Dwarfism in humans

Describe Mitochondrial Inheritance

-Mitochondria contain DNA with 37 genes.


-Mitochondrial DNA is maternally inherited/


-mtDNA mutates faster than nuclear DNA because there are no repair enzymes, lots of radicals, and no crossing over.


-Diseases effect muscle and vision.