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16 Cards in this Set
- Front
- Back
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inherited differences in response to drugs that result from ______ difference in protein required for tabolism, transport of drug action are the basis of pharmaogenomics
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genotype
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what percent of differences in drug response are due to genetics? ish
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15-50% but for some classes could account for 95%
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definition. rate in which drugs are absorbed, metabolized, and excreted
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pharmacokinetics
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def. drug effect on target
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Pharmacodynamics
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what are the phases of PK?
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I initial metabolism
II conjugation for excretion |
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what usually carries out phase I
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hydroxylation by P450
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what usually encodes PD's P450 system
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CYP
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if you have a slow metabolizer do you give more or less
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less!
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if you have a fast metabolizer do you give more or less?
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more!
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risk of warfarin has to do with what
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CYP
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what are the risks of warfarin
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clotting vs bleeding
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what are the risks of antidepressents
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non responders because of rapid metabolism or drug reactions if phase I sucks
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for which drug we talked about is genotyping a standard of care?
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thiopurines
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how does irinotecan work
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inhibits topo I
phase II in questions |
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what is the risk with succinylcholine
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prolonged effects for slow metabolizers
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what med means antiepileptics won't work
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SCN1A because use sodium channel in the brain to work
aka carbamazepine |
