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11 Cards in this Set
- Front
- Back
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Benign Rathke's pouch tumor with cholesterol crystals and calcifications
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craniopharyngioma
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Endoderm becomes what?
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gut tube epithelium and derivatives:
lungs liver pancreas, thymus, parathyroid thyroid follicular cells |
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Mesoderm becomes what?
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Muscles, bones, CT, dermis
serous lining of body cavities (peritoneum) eustachian tube spleen CV structures & blood lymphatics Bladder, urethra, kidneys, adrenal cortex vagina, testes, ovaries |
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Verterbral defects
anal atresia cardiac defects tracheo-esophageal fistula renal defects Limb defects All are what kind of defect? |
Mesodermal defects
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Decreased separation of hemispheres across midline --> results in cyclopia
Associated with Patau's syndrome, severe fetal alcohol syndrome and cleft lip/palate |
Holoprosencephaly
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Enlargement of the central canal of spinal cord.
Crossing fibers of spinothalamic tract are typically damaged first. "Cape-like" bilateral loss of pain and temperature sensation in upper extremities with preservation of touch sensation |
Syringomyelia
associated with Chiari II malformation Most common at C8-T1 |
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Aortic arch derivatives:
1st - 2nd - 3rd - 4th - 6th - |
1 - part of maxillary artery (branch of external carotid)
2 - stapedial A and hyoid A 3 - common Carotid A and proximal part of internal carotid A 4th - (on left) aortic arch; (on right) proximal part of right subclavian A 6th - proximal part of pulmonary AA and (on left) ductus arteriosis |
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Branchial pouch derivatives:
1st pouch - 2nd pouch - 3rd pouch - 4th pouch - |
1st pouch - middle ear cavity, eustachian tube, mastoid air cells
2nd pouch - epithelial lining of palatine tonsil 3rd pouch (dorsal wings) - inferior parathyroids 3rd pouch (ventral wings) - thymus 4th pouch - superior parathyroids |
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DiGeorge syndrome
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Aberrant development of 3rd and 4th pouches
Causes T-cell deficiency (thymic aplasia) and hypocalcemia (failure of parathyroid development) |
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MEN 2A
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Carcinogenic mutation of germline RET gene (neural crest cells)
- Adrenal medulla (pheochryomocytoma) - Parathyroid (tumor): 3rd/4th pharyngeal pouch - Parafollicular cells (medullary thyroid cancer): derived from neural crest cells --> associated w/ the 4th/5th pharyngeal pouches |
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Potter's syndrome
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Bilateral renal agenesis --> oligohydramnios --> limb deformities, facial deformities, and pulmonary hypoplasia
Caused by malformation of ureteric bud |
