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11 Cards in this Set

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  • Back
Does signal transduction always effect the transcription of a gene?
No. It may effect metabolism, proliferation, death, or locomotion.
Is a G protein a receptor or an intracellular messenger?
A G protein is an intracellular messenger which is activated by activation of a G-protein-linked receptor
Where can the nuclear receptor be located? How does the signal reach the receptor?
Nuclear receptors are located in the nucleus. Signals reach the receptors via secondary receptors.
Where in the cell is the G protein linked receptor produced (translated)?
Rough Endoplasmic Reticulum
Where does glycosylation of the G protein receptor occur?
In the lumen of the rough ER after the protein is produced.
Is CREB a transcription factor?
Yes, CREB is a CRE Binding Protein which binds to the CREB binding element of DNA and initiates transcription.
What does the term kinase mean?
Kinase: an enzyme (phosphotransferase) that phosphorylates substrates
Can GDP – GTP exchange be a modulated signal?
No! It’s an on/off switch.
Does phosphorylation by a kinase always switch on the signal?
No, it may switch off a signal.
Do cholera toxin and pertussis toxin bind to all G proteins?
Cholera toxin targets and locks  subunit of G proteins into the GTP form (always active) and adenylyl cyclasee is overactivated.

Pertussis toxin targets and binds  inhibitory G proteins in its inactive form; adenylyl cyclasee is not stopped
Outline the mode of action of a receptor tyrosine kinase.
• Ligand binds to tyrosine kinase receptor
• Oligomerization or Dimerization occurs
• Conformational change
• Autophosphorylation of tyrosine kinase occurs
• Signaling proteins bind to tryrosine kinase and become activated (either just by binding or by phosphorylation)
• Signaling cascade begins