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11 Cards in this Set
- Front
- Back
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Does signal transduction always effect the transcription of a gene?
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No. It may effect metabolism, proliferation, death, or locomotion.
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Is a G protein a receptor or an intracellular messenger?
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A G protein is an intracellular messenger which is activated by activation of a G-protein-linked receptor
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Where can the nuclear receptor be located? How does the signal reach the receptor?
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Nuclear receptors are located in the nucleus. Signals reach the receptors via secondary receptors.
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Where in the cell is the G protein linked receptor produced (translated)?
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Rough Endoplasmic Reticulum
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Where does glycosylation of the G protein receptor occur?
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In the lumen of the rough ER after the protein is produced.
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Is CREB a transcription factor?
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Yes, CREB is a CRE Binding Protein which binds to the CREB binding element of DNA and initiates transcription.
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What does the term kinase mean?
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Kinase: an enzyme (phosphotransferase) that phosphorylates substrates
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Can GDP – GTP exchange be a modulated signal?
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No! It’s an on/off switch.
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Does phosphorylation by a kinase always switch on the signal?
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No, it may switch off a signal.
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Do cholera toxin and pertussis toxin bind to all G proteins?
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Cholera toxin targets and locks subunit of G proteins into the GTP form (always active) and adenylyl cyclasee is overactivated.
Pertussis toxin targets and binds inhibitory G proteins in its inactive form; adenylyl cyclasee is not stopped |
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Outline the mode of action of a receptor tyrosine kinase.
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• Ligand binds to tyrosine kinase receptor
• Oligomerization or Dimerization occurs • Conformational change • Autophosphorylation of tyrosine kinase occurs • Signaling proteins bind to tryrosine kinase and become activated (either just by binding or by phosphorylation) • Signaling cascade begins |
