Endocrine System Test 1: Growing Up: Martin

Front 1

The rate of growth over time is more important than the actual weight and height at one time.

True or false

Back 1

True

Front 2

define short stature

Back 2

growth 2 standard deviation below normal

Front 3

The rate of growth over time is more important than the actual weight and height at one time.

True or false

Back 3

True

Front 4

What is the most important thing when looking at someone that may be shorter than normal?

Back 4

Get a good history

Front 5

define short stature

Back 5

growth 2 standard deviation below normal

Front 6

What is the most important thing when looking at someone that may be shorter than normal?

Back 6

Get a good history

Front 7

How do you access bone age?

Back 7

AP x-ray of the left wrist.

Front 8

What does bone age determine?

Back 8

the maturation of the epiphysis

Front 9

How do you access bone age?

Back 9

AP x-ray of the left wrist.

Front 10

What does bone age determine?

Back 10

the maturation of the epiphysis

Front 11

What is the most common cause of short children?

Back 11

short parents; familial short stature.

Front 12

In someone with familial short stature, what is their bone age equal to?

Back 12

their chronological age

Bone age=Chronological age

Front 13

In constitution growth delay, bone age is delayed by how many year?

Back 13

2-4 yrs.

Front 14

what is the nickname given to someone with constitutional growth delay?

Back 14

late bloomers.

Front 15

people with constitutional growth delay usually have a 1st degree relative with the same problem (mom or dad)

Back 15

blank

Front 16

A 12 year old boy is on the 5th percentile for height and the 10th for weight. Both his parents are below average for height. Which of the following is likely true?


Puberty will be delayed

His bone age will be delayed

Bone age>chronological age

Pubertal growth spurt will occur on time

Back 16

Pubertal growth spurt will occur on time

this pt has familial short stature.

Front 17

GH is synthesized, stored and secreted by...

Back 17

somatotrophs in the ant pituitary

Front 18

in what fashion is GH secreted?

Back 18

pulsitile

Front 19

when is GH normally secreted

Back 19

stage III and IV non-REM sleep.

Front 20

what hormone from the hypothalamus inhibits the release of GH

Back 20

somatostatin

Front 21

Sleep
Exercise
Physical stress
Puberty
Fasting

so these cause a release or decrease in release of GH

Back 21

release

Front 22

what 3 things decrease the release of GH

Back 22

hyperglycemia
hypothyroidism
glucocorticoids

Front 23

what does GH causes the production of?

Back 23

Insulin Growth factor (IGF)

Front 24

Someone def in GH whould have what in terms of bone age

Back 24

delayed bone age

Front 25

what is a good way to measure the amount of GH in a person

Back 25

IGF, this is because GH is released in pulses so can fluxuate. IGF has a long half life so reflects the 24 level of GH more accuratly.

Front 26

does insulin cause the release of GH?

Glucagon?

Back 26

yes

yes

Front 27

In what conditions is GH approved for tx?

Back 27

turner syndrome (45 X), GH def, chronic renal def, and in the case of servere anxiety from familial short stature.

Front 28

what is the major AE with use of GH?

Back 28

increased risk of malignancy

Front 29

hypersecretion of GH before puberty?

after puberty?

Back 29

giantism (open growth plates)

acromegaly (growth plates have closed)

Front 30

Enlargement of the hands and feet; Prognathism and overgrowth of facial bones. condition?

Back 30

acromegaly

Front 31

what is the Most common non-lethal chondrodysplasia?

Back 31

achondroplasia

Front 32

is achondroplasia AR or AD?

what is the defect?

what does this inhibit?

Back 32

AD

defect in FGFR3 gene

inhibits linear bone growth

Front 33

what is the malfunction in Diastrophic dysplasia?

Back 33

functional loss of the sulfate Ion transporter, DTDST, that is needed for cartilage synthesis.

Front 34

is diastrophic dysphasia AR or AD?

Back 34

AR

Front 35

do people with trisomy 21 tend to be short?

Back 35

yes

Front 36

what is the key dx feature needed for Turners syndrome?

Back 36

short stature

Front 37

Short Stature (key to dx)
Webbed neck *A
Increased carrying angle *B
Peripheral edema *C
Ovarian failure
45 X
Mosaic form may not present until puberty

Back 37

turner syndrome

Front 38

if female comes in with short stature, amenorrhea, and is an adolescent....

what should you look for?

Back 38

turner syndrome

Front 39

can maternal problems such as HTN, diabetes, toxins, and/or drug abuse cause intrauterine growth retardation?

Back 39

yes

Front 40

people with hypothyroidism would have what type of bone age?

Back 40

delayed bone age (hypothyroidism causes less GH to be released)

Front 41

Absence of distal femoral epiphysis. what condition should you think of?

Back 41

hypothyroidism

Front 42

Cortisol excess produces...

Back 42

short stature

Front 43

children with excess cortisol will have what type of bone growth?

Back 43

delayed bone growth

Front 44

What is Psychosocial Dwarfism

Back 44

kids that are neglected tend to be shorter. if you take this away their hormone levels will then even out.