Endocrine System Test 1: Adrenal Glands (Komar)

Front 1

where are the adrenal glands located?

Back 1

on top of the kidney

Front 2

what are the 2 main parts of the adrenal gland?

break down cortex and tell what is produced

Back 2

cotrex and medulla (medulla makes catecholamines)

zona glomerulosa (mineralcorticoids)

zona reticulara (glucocorticoids)

Zone fasiculata (androgens)

Front 3

what is an example of a mineralcorticoid?

Glucocorticoid?

Back 3

aldosterone

Cortisol

Front 4

what enzyme does the zona reticulars have that allows it to make androgens?

Back 4

cyp17

Front 5

what enzyme does the zona glomerulosa have that allows it to make mineralcorticoids?

Back 5

cyp11B2

Front 6

what regulates the zona fasiculata?

Back 6

ACTH

Front 7

what regulates the zona glomerulosa?

Back 7

ang II and extracellular K

Front 8

when glucocorticoids enter the blood they bind to what?

Back 8

Corticosteroid binding protein (CBP)

Front 9

what receptor does ACTH bind to on the zona fasiculata?

Back 9

melanocortin 2 receptor

Front 10

what 3 things do excess cortisol inhibit?

Back 10

the CRH receptor, release of CRH from the hypothalamus, and the release of ACTH.

Front 11

what does the binding of ACTH to melanocortin-2 do to StAR?

Back 11

increases StAR so you get more choelsterole into the mitocondria to make more glucocorticoids.

Front 12

what do glucocorticoids do for developing fetus?

Back 12

increase the production of surfactant.

Front 13

what kind of response does ANG II elict on the zona glomerulata?

what about extracellular k+

Back 13

increase the expression of cyp11B2

increase the expression of cyp11b2

Front 14

what receptor does aldonsterone (mineralcorticoid) bind to?

Back 14

mineralcorticoid receptor (type1 GR)

Front 15

what is the enzyme in the kidney that keep cortisone from becoming cortisol?

Back 15

11 beta HSD

Front 16

what are some roles of mineralcorticoids?

Back 16

regulate K+, BP, regulate water and sodium,

Front 17

what does excess aldonsterone lead to?

why?

Back 17

HTN, due to increase uptake of na+ and water from the kidney.

Front 18

what are 2 ex of catecholamines produced by the renal medulla?

Back 18

epi and NE

Front 19

what 3 things cause an increase in secretion of catecholamines?

Back 19

ACTH, SNS stimulation, and cortisol

Front 20

what does vasostatin do?

Catestatin?

Back 20

- BV

- nicotinic ach receptors to dec stimulation of catecholamine release.