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Regulation of the release of hormones from the anterior lobe of hypophisis (3 types)

1)Hypothalamic sescretion- polypeptide releasing hormones (+dopamine)


2)paracrine and autocrine secretions of the pituitary cells (growth factors + cytokines


3) feedback effect of circulating hormones (negative feedback TRH,TSH)

Gross structure and development of the pituitary gland

Weight- 0.6-1.5 (multiparous women)


Sella turcica, diaphragma turcica (sphenoid bone )


Origin:


-adenohypophysis-ectoderm of the orthopharynx ( rathke pouch)


-neurohypophysis- neuroectoderm of the 3rd ventricle (diencephalon)


Compounds:


-adenohypophysis- pars tubelaris, pars intermedia, pars distalis


-neurohypophysis - pars nevrosa, infundibulum (continuous of eminentia mediana)

Where are the hypothalamohypophyseal tracts ?

Infundibulum of the hypophysis


Blood supply of the pituitary gland?

Unusual,


- aa. Hypophyseales superiores- supply the median eminence, infundibulum, pars tuberalis


-aa Hypophyseales inferiores- pars nevrosa


---hypothalamohypophyseal portal system

Hypothalamohypophyseal portal system

The superior hypophyseal arteries, supply the median eminence, infundibulum and pars tuberalis. The blood from there drains into the hypophyseal portal veins which gives a rise to a secondary capillary plexus, which carries the neuroendocrine secretions from the hypothalamus to the pars distalis (anterior lobe) , then to the sinus cavernosus.

Nerve supply (pituitary gland)

Infundibulum and pars nevrosa- posterior lobe


Anterior lobe- postsynaptic fibers ANS

GH Somatotropin

Stimulates liver to synthese and secrete insuline like growth factor (igf 1), which stimulates chondrocytes in skeletal bones, and progenitor cells in skeletal muscles

Prolactin PRL

Promotes mammary gland development, milk formation initiation, secretion of casein, lactalbumin, lipids and carbohydrates in milk

ACTH Adrenocorticotrophic hormone

Maintains structure, stimul secretion of glucocorticoids and gonadocorticoids by zona fasciculata and zona reticularis of the adrenal cortex

FSH foliclestimulating hormone

Ovogenesis and spermatogenesis stimulation

LH- luteinising hormone


Final matruration of the ovarian folicle regulation, ovulation regulation, corpus luteum formation regulation, stimulates steroid secretion by graafov folikul i corpus luteum


Maintenance of and androgen secretion of the Leydig cells

Thyrotropic hormone TSH

Growth thyroid epithelial cells, stimulation production and release of thyroglobulin and thyroid hormones