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66 Cards in this Set
- Front
- Back
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In the cat give the papillomaviruses associated with the following diseases - viral plaque/ bowenoid in situ carcinoma - cutaneous squamous cell carcinoma - basal cell carcinoma - oral papilloma - oral SCC - feline sarcoid |
F : no more risk to contract the infection
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Give 4 diseases/syndromes associated with FeLV infection |
- generalized dermatophytosis - demodicosis - Malassezia dermatitis - cutaneous horns - bowenoid in situ lesions - giant cell dermatosis |
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Cutaneous horns associated with FeLV infection are commonly seen on the nose and eyelids : T or F |
F : rarely |
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Give the DD of cutaneous horns in FeLV ( 6 ) |
-Cutaneous horn induced by papilloma -actinic keratosis -bowenoid in situ -SCC -dilated pore -keratoacanthome - |
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Immunohistochemistry can be used to demonstrate the presence of FeLV in a skin lesion: What antigen is targeted ? |
gp70 |
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Giant cell dermatosis is associated with ____ virus. What is the common clinical features ? |
- FeLV virus - pruritus, crusts; face or head involvement, also feet & footpads or mucocutaneous jonctions |
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Give the key histo features of the giant cell dermatosis |
- heavily crusted and hyerplastic epidermis - syncytial type giant cell in epidermis and ORS (isthmus) - apoptotic kerztinocytes around - gp 70 protein |
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What is the most common clinical sign in FIV ? |
Chronic or recurrent oral disease |
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Give 2 diseases associated with FeSV = feline sarcoma virus |
Multicentric fibrosarcoma in young cats Liposarcomas in kitten |
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What is the most common virus implicated in feline poxvirus infection ? |
Cowpox |
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What is the main source of poxvirus for cats ? |
Rodents : mice and voles Cat to cat; cat to dog; cat to human can also occur |
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Clinical lesion of pox virus in cat ? |
Pox = pocks = crateriform lesion —> ulcerated nodule |
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Poxvirus : What species is typically at risk of developping a rapid progressive fatal pneumoniae ? |
Exotic felids : cheetahs |
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Give the two best methods to make a precise diag of pox virus infection in cat |
-isolation of virus - PCR |
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What is the ethiologic agent for feline infectious peritonitis and Give the main histo features found in the skin lésion |
Coronavirus - pyogranulomatous infiltrate in the superficial to deep dermis (depending on the cases), around blood vessels - dermal necrosis and hemorrhage Feline coronavirus AG have been detected in the macrophages and also in blood vessels walls |
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Canine distemper : virus ? Classic clinical signs and skin lesions |
Paramyxovirus Clinical signs : severe respiratory, gastrointestinal and neuro disorders Skin lesions : hard pad disease (nasal and footpads hyperkeratosis); young puppies also have widespread impetigo |
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Give the histo feature of canine distemper (paramixovirus) |
- marked ortho and parakeratotic hyperkeratosis - cytoplasmic inclusion bodies in keratinocytes - occasionally multinucleated syncytial giant cells |
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Orf (parapoxvirus) can infect dogs and provoke skin lesions : acute moist dermatitis, ulceration and crusts. Histo can show among other the presence of acantholytic cells in the SS T or F ? |
T |
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alpha-herpes virus causes a fatal disease : name it and Give an important clinical feature |
Pseudorabies Maniacal upper body pruritus |
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Feline rhinotracheitis infection : What is the virus and What are its characteristic ? |
Feline herpes virus 1 Double stranded DNA virus Enveloped |
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Feline herpes virus infection can be associated with an impression dermatitis : which one ? |
Ulcerative and necrotizing facial dermatitis and stomatitis |
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What immune mediated disease can be seen with upper respiratory tract infection with herpes virus ? |
Exfoliative erythema multiforme |
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Histological features of herpetic ulcerative and necrotizing facial dermatitis ? |
- ulcerative and ulcerative often necrotic dermatitis - suppurative folliculitis and furonculosis - multinucleated keratinocytic giant cells and intranuclear inclusion bodies in giant cells and orher keratinocytes - unique feature = necrosis of epitrichial sweat glands |
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Give the possible treatment for herpes virus dermatitis |
- treatment of bacterial surinfection (some Times it is enough) - lysine : 250mg without glycol/24h - IFN alfa : 1million unit/square meter SC 3 Times weekly - recombinant IFN omega - oral famciclovir 90mg/kg - topical imiquimod 2-3 days /week - topical 0.5% cidofovir (keratitis) |
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Adult cats are more susceptible than kitten for the severe hemorrhagic and highly virulent biotype of Feline Calicivirus True or False |
True |
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What are the 6 different syndromes associated with papillomavirus in dogs ? |
- oral papilloma - veneral papilloma - exophytic - inverted - multiple on footpads - pigmented plaque |
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What is a koilocyte? |
Keratinocytes with clear cytoplasm and pyknotic nuclei. Pale basophilic intranuclear inclusion bodies may be found in upper stratum spinosum or SG. |
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The papillomavirus infects and multiply in the stratum spinosum leading to acanthosis: T or F ? |
F : it infects the basal keratinocytes then génome replication in spinous and granulous layers and release new infectious virus in keratinized squames |
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Give the three cytopathic effects of papillomaviruses |
- increased mitotic rate : acanthosis and hyperkeratosis - formation of koilocytes in upper SS - giant keratohyalin granules in the SG |
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What antibiotique can be useful in the treatment of both oral and cutaneous papilloma ? |
Azithromycin 10mg/kg/d 10 days |
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Interferon alpha can be given at low dose (orally) or high dose (intra lesional) may induce régression in some cases of oral papillomas. T or F ? |
T |
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Interferon alpha can be given at low dose (orally) or high dose (intra lesional) may induce régression in some cases of oral papillomas. T or F ? |
T |
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Dogs recovering from oral papillomas are immune from reinfection T or F ? |
T |
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For what type of papillomavirus lesion pugs and miniature Schnauzer are predisposed ? |
Pigmented plaques Possible AD mode of transmission in pugs |
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Key features of canine pigmented viral plaques ? |
- sharply demarcated - surface And infundibular follicular epithelial pseudocarcinomatous hyperplasia and dysplasia - koilocytosis and viral inclusion bodies are rarely seen |
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Name 4 diseases syndromes associated with papillomaviruses in the cat |
- feline cutaneous papillomas - feline sarcoids - feline viral plaques - feline bowenoid in situ carcinoma and invasive scc |
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Three most common viruses associated with syncytial giant cells |
FeLV Herpes virus Paramyxovirus (Virus with enveloppe) |
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2 viruses with intranuclear inclusion 1 virus with intracyto inclusion 1 virus with intra cyto and/or intra nuclear |
Intranuclear : herpes, papilloma Intracyto : pox Both : paramyxovirus |
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PapillomaV within the same genus have greater than __% of similarity and within the same type have greater than ___% of similarity |
60% 90% |
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What do E6 and E7 proteins provoke in keratinocytes ? |
They induce the proliferation of suprabasal cells High risk for cancer dev (ex cervical cancer in human) : if integrated into DNA / in cats and dogs the role of E6 and E7 have not been fully determined |
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What is the role of IgG in papillomavirus infection ? |
It blocks entry of the PV in the basal cells, preventing further infection but do not influence resolution of an established infection |
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What is the most common form of papilloma in dog ? |
Oral papilloma |
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What protein is a good marker for detection of papillomavirus infection in histo exam ? Give 3 advantages |
- p16 detects an effect of PV infection rather than presence of PV protein in the lesion - p16 immunostaining is increased even if no viral replication is present - human anti p16 antibodies have been validated for use in dogs and cats |
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In addition to PCR, reverse transcriptase PCR can be used to detect PV gene expression in lesions T or F ? |
T |
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In situ hybridisation can be used to localize PapillomaV DNA or RNA within a lesion T or F |
T |
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What papillomaV are responsible for : 1.Oral papillomatosis ? 2.canine cutaneous papillomas? |
1. CPV-1 2. CPV-1,2,6,7 M |
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Inverted papillomas induced by CPV-2 have shown evolution into SCC in some immunodeficient dogs : T or F |
T |
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Malignant evolution of pigmented plaques have been associated with CPV-9, 12 and 16 T or F |
T |
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In cats : - oral papilloma are induced by ? - Bowenoid in situ and viral plaque by ? |
FcaPV1 FcaPV2 |
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FcaPV-2 may influence the development of only 10% of feline cutaneous SCC T or F |
F : 33-45% |
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A case of generalized verrucosis was described in a dog in association with CPV9 : T or F ? |
T |
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Two cutaneous horns associated with CPV1 was described in a pit bull dog : T or F ? |
T Nb : CPV1 has also been associated with oral papilloma, cutaneous exophytic and endophytic papilloma and invasion SCC |
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In human cutaneous horns have been described with HPV1, HPV2 and HPV16 T or F |
T |
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What particular features were recently described in Devon Rex cat with BISC ? |
- BISC develop at younger age in Devon rex - BISC in Devon rex have a more agressive behavior than in other cats - Numerous BISC with agressive behavior (transformation into SCC) and pulmonary metastasis FcaPV2 copies and E6/E7(=p16 detection) expression either in BISC lesion or SCC or pulmonary metastasis |
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What type of papillomavirus are responsible for canine pigmented plaques? |
Chipapillomavirus |
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What intervention was recently described to treat extensive pigmented viral plaque in à golden retriever dog ? |
Carbon dioxide laser treatment |
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What virus usually found affectons dogs, can affect the Eurasian Lynx ? |
Distemper virus |
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In paramixovirus : can you observe syncytia? Intracytoplasmic inclusion bodies ? Intranuclear inclusion bodies ? |
Yes Yes Yes |
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Dual infection in a cat with papillomavirus and orthopoxvirus has been described in Switzerland in 2013 : T or F |
F : paramyxovirus and orthopoxvirus |
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What is your diagnosis ? What pathogen is implicated ? |
SCC Cyprinid Herpes virus 1 A direct cause could not be proven |
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What cyprinid herpes virus affect carp ? Goldfish? What is the usual presentation associated with CyHV1 ? |
Carp : CyHV1 and CyHV3 Goldfish : CyHV2 In carp CyHV1 usually provokes carp pox : flat epidermal papilloma that resolve spontaneously when temperature above 20 degrees |
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A novel papilloma has been revently described in association with BISC and SCC T or F ? |
F : BISC and basal cell carcinoma |
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Very recently a case report described a cat with a chronic monolateral ulcerative dermatitis on one pinna. What was the pathogen ? |
Feline Herpes virus 1 |
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What multimodal treatment was very recently described to treat a disseminated cutaneous viral papillomatosis associated with CPV2? |
- surgical debulking - topical imiquimod 5% - five doses of recombinant CPV2 L1 vaccine every 14 days - excision of the remaining lesions |
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In Devon rex it has been shown that papillomavirus can induce SCC and metastasis : T or F ? |
T |
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Cryotherapy can be a good option for treating persistant papilloma in dogs : T or F ? |
T : five to six freeze thaw cycles using liquid nitrogen cryotherapy |
