Derm 1 - Lund Skin Manifestations Of Systemic Disease

Front 1

Etiology: Hypersensitivity to a drug, viral, bacterial, idiopathic
Skin lesions: Urticarial, target, blisters
Stevens-Johnson syndrome - major version

Back 1

Erythema Multiforme

Front 2

Neutrophilic destruction of vascular channels - large and small vessel types (immune complex problem)
MANY causes

Back 2

Vasculitis

Front 3

Persistent red/blue mottling of the skin in a net-like pattern. Non-specific as a sign of sludging.
Etiologies: connective tissue disease, calciphylaxis, cholesterol emboli

Back 3

Livedo Reticularis

Front 4

Purple macules and plaques of skin
Etiologies: vascular integrity compromised, coagulopathy, immune-mediated destruction

Back 4

Purpura

Front 5

tender papulopustules that degenerate into ulcerated lesions with bluish border.
Etiology: *Inflammatory bowel disease, malignancies - leukemia, connective tissue disease, monoclonal gammopathy

Back 5

Pyoderma gangrenosum

Front 6

Disorder that has acute onset of fever, leukocytosis, erythematous plaques with neutrophils.
More in females, often after nonspecific GI or respiratory infection
Painful plaques and nodules (face, extremities, less trunk)
Assoc diseases: myeloproliferative malignancy, Sjogren's, RA, SLE, pregnancy, thyroiditis

Back 6

Sweet's syndrome

Front 7

Cutaneous features of what disease?
Classic malar rash and photosensitivity (butterfly rash), Raynauds, vasculities, digital infarcts, discoid scarring

Back 7

Systemic Lupus Erythematosis

Front 8

Skin findings - sclerosis of face and trunk, CREST syndrome, purse string/no wrinkles, telangiectasia

Back 8

Scleroderma

Front 9

Inflammatory myopathy with heliotrope, Gottron's papule, and violaceous erythema over the hands. Proximal motor weakness of shoulder/hip girdle muscles

Back 9

Dermatomyositis

Front 10

Associated with severe, chronic hypothyroidism. Face (eyelid/lips) can be prominently swollen, but not pitted with pressure. Mucin deposited around bvs and hair follicles

Back 10

Myxedema

Front 11

Most commonly with hyperthyroidism. lower 2/3 of dermis expanded by mucin

Back 11

Pretibial myxedema

Front 12

**Female greater than male ratio. Lesions are waxy, indurated, yellow/brown patches often on anterior shins but also foreamrs, hands, trunk
2/3 of patients have diabetes mellitus
Biopsy shows palisaded and granulomatous dermatitis involving full thickness dermis and can extend into subcutaneous fat

Back 12

Necrobiosis Lipoidica

Front 13

Found in infants. Multiple brown/red nodules which urticate and become vesicular. Mast cells. Can progress to systemic mastocytosis, usually self-resolving

Back 13

Urticaria pigmentosa

Front 14

Fibroma of the skin associated with tuberous sclerosis, mid-face, and by cuticles of nails

Back 14

Adenoma sebaceum

Front 15

Cutaneous features include axillary freckling, cafe au lait macules, plexiform neuromas, eye findings

Back 15

Neurofibromatosis

Front 16

Darker, velvety thickening of the skin folds, especially the neck

Back 16

Acanthosis Nigricans

Front 17

Hereditary AN = no associated endocrine disorder
____ AN - various endocrine disorders (insulin-resistant diabetes mellutis, hyperandrogenism, cushings, hypothyroidism)
Pseudo Acanthosis Nigricans - due to ____. Produces insulin-resistant. Pronounced in upper, inner thigh and many skin tags
Drug-induced AN - _____ acid, glucocorticoids, growth hormones
Malignant AN - lips and ____ mucosa affected. Paraneoplastic process.

Back 17

benign
obesity
nicotinic
oral

Front 18

Autosomal dominant, small irregular hyperpigmented macules localized to oral mucosa, lips, perioral skin, dorsal fingers.
Majority have multiple polyps in the small intenstine (malignant 2-3% of the time)

Back 18

Peutz Jeghers