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521 Cards in this Set

  • Front
  • Back
Catabolic Reactions
Metabolism
Break down large chemicals and release energy
Anabolic Reactions
Metabolism
Build up large chemicals and require energy
Absorption
Passage of nutrient molecules through the lining of the digestive tract into the body. Absorbed molecules pass through cells lining digestive tract via diffusion or active transport.
Transport
Circulation of essential compounds required to nourish the tissues and removal of waste products from tissues.
Assimilation
Building up of new tissues from digested food materials
Respiration
Consumption of oxygen by the body. Cells use the oxygen to convert glucose to ATP.
Synthesis
Creation of complex molecules from simple ones.
Anabolism
Homeostasis
Regulation by hormones and the nervous system of the body to maintain its internal environment in changing external environment
What elements are the primary components of living things?
Carbon
Hydrogen
Oxygen
Nitrogen
Sulfur
Phosphorus
What are some components (elements) of the protoplasm?
Magnesium
Iodine
Iron
Calcium
What are carbohydrates composed of?
Carbon, Hydrogen and Oxygen in a 1:2:1 ratio
Uses of carbohydrates
Store energy: glucose and glycogen (animals) or starch (plants)
Structural molecules
How are disaccharides and polysaccharides formed?
Dehydration synthesis
Example of monosaccharides
Glucose
Fructose
Example of disaccharides
Maltose
Example of polysaccharides
Cellulose
Starch
Composition of lipids
Three fatty acid molecules bonded to a glycerol backbone.
Do not form polymers
Fatty Acids
Composed of long carbon chains that make them hydrophobic and carboxylic acid groups that make them acidic.
Are polysaccharides water soluble?
No
Role of Lipids
Chief means of food storage- release more energy per gram weight than any other biological compounds.
Provide insulation- major component of fatty tissue (adipose)
Phospholipids
Contain glycerol, two fatty acids, a phosphate group and nitrogen-containing alcohol
Waxes
Esters of fatty acids and monohydroxylic alcohols
Steroids
Have three fused cyclohexane rings and one fused cyclopentane ring
Examples of steroids
Cholesterol
Sex hormones
Corticosteroids
Carotenoids
Fatty acid like carbon chains with conjugated double bonds carrying six membered carbon rings at each end
Carotenes and xanthophylls are
subgroups of carotenoids
Poryphyrins
Contain four joined pyrrole rings that are often complexed with a metal.
Protein composition
Polymers of amino acids
Composed of C, H, O,and N and sometimes P and S
Peptide bonds join together ___________ via ____________ reactions
Amino acids
Dehydration
Primary Structure of Proteins
Sequence of amino acids
Secondary Structure of Proteins
Proteins coil and fold to form alpha helices and beta-pleated sheets
Argininine, Lysine and Histidine are examples of
Proteins
Simple proteins
Composed entirely of amino acids
Albumins and Globulins
Functional proteins that act as carriers or enzymes
Globular in nature
Scleroproteins
Fibrous structural proteins
Example: collagen
Conjugated Proteins
Contain a simple protein portion plus at least one nonprotein fraction
Mucoproteins
Protein bound to a carbohydrate
Chromoprotein
Protein bound to pigmented molecules
Metalloproteins
Protein complexed around a metal ion
Nucleoproteins
Proteins containing histone or protamine bound to nucleic acids
Function of Hormones
Chemical messengers secreted into the circulation
Insulin and ACTH are examples of
Hormones
Enzymes- Function
Biological catalysts
Structural Proteins
Extracellular or intracellular proteins that contribute to physical support of cell/tissue
Transport Proteins
Carriers of important materials
Antibodies
Bind to foreign particles
Proteins
Substrate
Molecule on which an enzyme acts
Active Site
Area on enzyme where substrate binds
Lock and Key Theory (enzyme function)
Enzyme function
Spacial structure of enzyme's active site is complementary to spatial structure of substrate.
Largely discounted
Induced Fit Theory (enzyme function)
Active site has flexibility of shape. Conformation changes when appropriate substrate comes in contact
Are enzyme reactions reversible?
Yes
Hydrolysis Reaction- Function
Digest large molecules into smaller components
Involve enzyme use
As temperature increases, rate of eznyme action
Increases up to an optimal temperature which could deactivate the enzyme by denaturing it
How does pH effect enzyme activity?
There is usually an optiaml pH above and below which enzymatic activity declines.
Usually 7.2 is optimal pH
Lactase
Enzyme that hydrolyses lactose to monosaccharides glucose and galactose
Hydrolysis reaction
Proteases
Enzyme that degrades proteins to amino acids and lipases
Hydrolysis reaction
Synthesis Reactions- Function
Growth, repair, regulation, protection and production of food reserves.
Cofactors
Nonprotein molecules required by some enzymes for them to become active
Prosthetic Groups
Cofactors which bind to the enzyme by strong covalent bonds
Nucleic Acids- Composition
Contain elements C, H, O, N, P
Polymers of nucleotides
Function of nucleic acids
Code all of the information required by an organism to produce proteins and replicate
Cell Theory
All living things are composed of cells
Cell is basic unit of life
Cells arise from pre-existing cells
Cells carry genetic information in the form of DNA which is passed from parent to daughter cell
Resolution
Differentiation of two closely situated objects
Types of Microscopes
Compound Light Microscope
Phase Contrast Microscope
Electron Microscope
Compound Light Microscope
Uses two lenses or lens systems to magnify objects
Kills specimen
Phase Contrast Microscope
Permits study of living cells
Electron Microscopy
Uses beam of electrons to produce higher magnification than other microscopes.
Usually not used to examine live specimen
Centrifugation
Used to separate cells or mixtures of cells without destroying them by spinning the fragmented cells at high speeds
What parts of the cell membrane move freely within the membrane?
Lipids and Proteins
Is the cell membrane permeable to water?
Yes, it is a small molecule like Oxygen
Carrier Proteins
Assist large, charged molecules in crossing the membrane
Histones
Complexed with DNA to form chromosomes
Nucleolus
Dense structure in nucleus where ribosomal RNA synthesis occurs
Glycosylation occurs in the
Golgi apparatus
Mitochondria are the sites of
aerobic respiration
Cyclosis
Transport with in the cytoplasm
Vacuoles and Vesicles
Membrane bound sacs involved in transport and storage of materials
Vacuoles- plant cells
Centrioles
Specialized microtubule involved in spindle organization
Plant cells do not have centrioles
Hydrolytic Enzymes
Used for intracellular digestion
Found in lysosomes
Difference between plant cells and animal cells
In plants:
no centrosome
cell wall of cellulose
chloroplasts
many vacuoles or one large vacuole
Osmosis
Simple diffusion of water from low solute concentration to high solute concentration
Lysis
When water flows from hypotonic solution to inside of cell causing it to burst
Facilitiated Diffusion
Passive Transport
Net movement of dissolved particles down their concentration gradient through channels or carrier proteins in cell membrane
Does not require energy
Active Transport
Net movement of dissolved particles against their concentration gradient with help of transport proteins
Requires energy
Brownian Movement
Movement of particles due to kinetic energy which spreads small suspended particles throughout cytoplasm
Cyclosis/Streaming
Circular movement of cytoplasm around cell transport molecules
Diffusion
Means of transport for food and oxygen from the environment to the cells
Circulatory System
In complex animals- vessels transport fluid and a pump drives circulation
What are the two means of movement of materials?
Diffusion or a circulatory system
Karyokineses
Nuclear division
Cytokinesis
Cell division
Interphase
90% of cell life
Each chromosome is replicated forming two sister chromatids held together in the centromere
Individual chromosomes are not visible- chromatin
Prophase
Chromosomes condense and centriole pairs separate and move towards opposite poles
Spindle apparatus forms and nuclear membrane dissolves
Metaphase
Spindle fibers attach to chromatids aligning them at the center of cell forming metaphase plate
Anaphase
Sister chromatids separate and are pulled toward opposite poles
Telophase
Spindle apparatus has disappeared
Nuclear membrane forms around newly formed chromosomes
Chromosomes uncoil resuming interphase form
Cytokinesis
Cytoplasm divides into two daughter cells and cleavage furrow forms separating two nuclei.
Plant Cell Division
Plant cells lack centrioles
Do not form cleavage furrow- divide by formation of cell plate
Difference between mitosis and meiosis?
Mitosis preserves diploid number of cell, meiosis produces haploid number and produces four haploid gametes
Prophase I
Chromatin condenses, spindle apparatus forms.
Chromosomes come together and intertwine
Crossing over takes place.
Synapsis
Process in which homologous chromosomes come together and intertwine
Meiosis- prophase I
Tetrad
Meiosis I- prophase I
Name given to each synaptic pair of homologous chromosomes. Contains four sister chromatids
Crossing Over
Meoisis I- Prophase I
Process during which chromatids of homologous chromosomes break at corresponding points and exchange equivalent pieces of DNA.
Does crossing over take place between homologous chromosomes or sister chromatids?
Homologous chromosomes
Anaphase I
Homologous pairs from each tetrad separate and are pulled to opposite poles.
Disjunction
Each chromosome of paternal origin separates from homologous maternal origin chromosome and can either chromosome can end up in either daughter cell.
What are the four types of asexual reproduction?
Fission
Budding
Regeneration
Parthenogenesis
What organisms reproduce asexually?
All prokaryotes
Some invertebrate animals
All plants
Binary Fission- Process
DNA replicates and new plasma membrane and cell wall grow inward along midline dividing it into two daughter cells.
What kinds of organisms does binary fission take place in?
One-celled organisms
Budding- Process
Cell membrane pinches inward forming new, genetically identical (to parent cell) cell that is smaller (but grows to adult size). The new cell may separate from arent or remain attached
Regeneration- Process
Regrowth of lost/injured body part via mitosis of cells.
Parthenogenesis- Process
Natural process of the development of an unfertilized egg into an adult organism.
What are the two means of asexual reproduction in plants?
Spore formation
Vegetative propagation
Alternation of Generation
A diploid generation is succeeded by a haploid generation
Spore Formation- Process
Diploid sporophyte generation produces haploid spores that develop into haploid gametophyte generation.
What are spores?
Specialized cells with hard coverings that prevent the loss of water
Vegetative Propagation- Process
Undifferentiated tissues in plants provide a source of cells that can develop into an adult plant without genetic variation.
Meristems
Undifferentiated tissues in plants
Bulbs (Natural Vegetative Propagation)
Split to form several bulbs
Tubers (Natural Vegetative Propagation)
Underground stems with buds.
Can develop into adult plants
Runners (Natural Vegetative Propagation)
Stems running above and along the ground extending from main stem.
Can produce new roots and upright stems
Rhizomes (Natural Vegetative Propagation)
Woody underground stems
Can develop new upright stems
Auxins (Artificial Vegetative Propagation)
Synthetic plant hormones.
Used to accelerate root formation from a cut piece of stem.
Layering (Artificial Vegetative Propagation)
Stems of certain plants are bent to ground where they take root
Scion-stock connection (Artificial Vegetative Propagation)
Stem of one plant (scion) is connected to rooted stem of another related plant (stock). Cambium tissues are in contact.
What are the three things sexual reproduction requires?
1. Production of functional sex cells (gametes) by adult organisms)
2. Union of sex cells (fertilization) and formation of a zygote
3. Development of zygote into another adult
Gonads
Specialized organs that produce gametes
Male gonads?
Female gonads?
What do they produce?
Testes- sperm
Ovaries- oocytes
Hermaphrodites
Have both functional male and female gonads
Spermatogenesis- what and where?
Sperm production
Seminiferous tubules
Spermatogenesis- process
Diploid cells (spermatogonia) undergo meiosis producing four haploid sperm.
Structure of Sperm
Elongated cell with head made almost entirely of the nucleus with paternal genome in it, a tail (flagellum), neck and body
Oogenesis- what and where?
Production of female gametes
Ovaries
Oogenesis- Process
Diploid primary female sex cell undergoes meiosis in ovaries to produce a single mature egg.
Polar Body
Produced during oogenesis.
EAch meoitic division makes small cells with little more than nucleus.
Mature Ovum- Structure
Large cell with most of cytoplasm (from meiotic divisions)
Fertilization
Union of the egg and sperm nuclei to form a zygote with diploid number
External Fertilzation- where?
Occurs in vertebrates that reproduce in water.
External Fertilization- Process
Female lays eggs in water
Male deposits sperm in vicinity
Lower chances of fertilization so many eggs are layed
Internal Fertilzation- where?
Terrestrial vertebrates
Internal Fertilization- Process
Direct route for sperm to reach egg cell- higher chances of success so females produce fewer eggs.
Pathway of sperm
Seminiferous tubules to
Epididymis to
Vas Deferens to
Ejaculatory Duct to
(nothing)
Urethra to
Penis
SEVEN UP
Where are the testes located? Under what conditions?
In external pouch- scrotum
Testes maintained at temperature 2-4 degrees Celsius lower than body temperature.
Where is testosterone produced?
Testes
What does testosterone do?
Regulates secondary male characteristics- hair, voice
Where are the ovaries located?
In the abdominal cavity below the digestive system.
What are the ovaries made of?
Thousands of follicles (mulitlayered sac of cells)
What produces estrogen?
Follicle cells of ovaries
How often is an ovum released from the ovary? Where is it released to?
Once a month
Into the abdominal cavity to the oviduct
Fallopian tubes open up into the __________
Uterus
Cervix is the
end of the uterus
site of sperm deposition
passageway for baby to be expelled
What regulates the secretion of estrogens and progesterone?
LH and FSH
What are the two female sex hormones?
Estrogen
Progesterone
What does GnRH do? (ovaries)
Regulates LH and FSH in ovaries
Estrogens- role
Necessary for normal female maturation
Progesterone- role
Stimulates development and maintenance of endometrial walls in preparation for implantation
Menstrual Cycle- phases
Follicular
Ovulation
Luteal Phase
Menstruation
Freakin OLd Man
Follicular Phase of Menstrual Cycle
Follicle simulating hormone promotes development of the follicle which grows and starts to secrete estrogen
What triggers ovulation?
LH surge at midcycle
Ovulation- what happens?
Mature ovarian cycle bursts and releases an ovum.
LH
Luteinizing hormone
Female rep.
FSH
Follicle Stimulating Hormone
Female rep.
Luteal Phase
Ruptured follicle develops into corpus luteum which secretes estrogen and progesterone.
Progesterone produces secretions to prepare endometrium glands for implantation of embryo
Menstruation
If ovum isn't fertilized, corpus luteum atrophies causing drop in progesterone and estrogen levels causing endometrium to slough off=menstrual flow.
Menstruation- what happens if fertilization occurs?
Developing placenta produces hCG (human chorionic gonadotropin) maintaining corpus luteum
Does the sporophyte or gametophyte generation dominate in plants?
Sporophyte
Gametophyte Generation in Plants
Haploid gametohpyte generation prouces gametes by mitosis. Union of male and female gametes at fertilization restores diploid sporophyte generation
SEXUAL REPRODUCTION
Sporophyte Generation in Plants
Diploid sporphyte generation produces haploid spore by meiosis which divide by mitosis to produce the haploid or gametophyte generation
ASEXUAL REPRODUCTION
Angiosperms
Flowering plants
Stamen- What? Components
Male organ of flower
Consists of stalk-like filament with terminal sac called anther
Anther- What? Where?
produces haploid spores
Stamen
Pistil- What? Parts
Female organ of flower
Stigma, style and ovary
Stigma- What?
Sticky, top part of pistil
Style- What?
Tube-like structure connecting stigma to ovary in pistil
Ovary of Angiosperms
Enlarged base of pistil
Contains one or more ovules
Sepal- What? Role
Green leaves
Cover and protect flower bud during early develoment
The male gametophyte of angiosperms is____
the pollen grain
Pollen Grain (Angiosperms)
Contains a tube nucleus and a generative nucleus formed by mitosis of a microspore.
How are the male gametes of angiosperms formed?
Pollen grains are transferred from the anther to the stigma where the generative nucleus divides forming sperm nuclei
Where does the female gametophyte of angiosperms develop?
In the ovule from one of four spores
What does the embryo sac of angiosperms contain?
two polar endosperms and an egg nucleus
How does fertilization in angiosperms occur?
Sperm nuclei enter the embryo sac. One sperm nucleus fuses with the egg nucleus to form the diploid zygote which develops into the embryo.
The other sperm nucleus fuses with the two polar bodies to form the endosperm= food for embryonic plant.
Components of the embryo:
Epicotyl
Cotyledons
Hypocotyl
Endosperm
Seed Coat
Epicotyl (Angiosperm embryo)
Precursor of upper stem and leaves
Cotyledons (Angiosperm Embryo)
seed leaves
Hypocotyl (Angiosperm Embryo)
Develops into lower stem and root
Endosperm (Angiosperm Embryo)
Grows and feeds embryo
Seed Coat (Angiosperm Embryo)
Develops from outer covering of ovule
What is the means of seed dispersal in angiosperms?
In the form of fruit- enables seed to be carried by air, water or animals until its release
Apical Meristem
Found in tips of roots and stems- growth in length occurs here
Lateral Meristem
Located between xylem and phloem. Tissue here permits growth in diameter.
Alleles are
Alternative forms of a gene
Where do the two alleles for each inherited trait in an organism come from?
One allele is inherited from each parent
What happens to the two inherited alleles during meiosis?
They segregate, resulting in gametes with only one allele for any given trait
Mendel's Law of Dominance
Dominant allele appears int eh phenotype
F in F generation
Filial
Testcross
Used to predict the genotype of a dominant phenotype.
Mendel's Law of Independent Assortment
Crossing over exchanges information between chromosomes and can break the link of certain patterns of genes that stay together during crossing over.
Incomplete Domiance
When phenotypes are a blend of parental phenotypes. The phenotype of the heterozygote is an intermediate of the phenotypes of the homozygotes
Codominance
Multiple alleles exist for a given gene more than one of which is dominant. When both dominant alleles are present, both are expressed
ABO blood groups are an example of
codominance
Autosomes
All chromosomes other than sex chromosomes
Sex-linked Genes
Genes on X or Y chromosome
In humans usually on X
In males, recessive genes carried on X chromosome produce ____________ phenotype
Recessive
Hemophilia and Color-blindness are examples of
Sex-linked recessive traits
Males affected by a X-linked disorder can or cannot pass the trait onto their male offspring? female?
cannot
can
Why are fruit flies so popular for genetic research?
Short life cycle
Reproduces in large numbers
Large chromosomes
Few chromosomes
Frequent mutations
Nondisjunction
Failure of homologous chromosomes to separate during meiosis I or failure of sister chromatids to separate during meiosis II
Trisomy
Zygote has three copies of a chromosome.
Caused by nondisjunction
Monosomy
Zygote has only one copy of a chromosome due to nondisjunction
Down Syndrome is caused by
Trisomy of chromosome 21
What causes chromosomal breakage?
Can happen spontaneously or by environmental factors
Mutations in somatic cells can lead to ________
tumors
Mutations in gametes ________
are passed on to offspring
Silent Mutations
Mutations in regions of DNA that don't code for proteins and are not expressed in phenotype.
Mutagenic Agents
Induce mutations
Examples- uv, x rays, chemical compounds
Phenylketonuria
Molecular disease caused by inability to produce enzyme for metabolism of phenylalanine
Sicle Cell Anemia
Red blood cells become crescent shaped because they contain defective hemoglobin. Caused by substitution of valine for glutamic acid
Purines (list)
Adenine
Guanine
"ine"
Pyrimidines
Cytosine
Thymine

y's in all three
Phosphate connects to ____________ connects to ____________ in DNA
sugar
base
Semiconservative Replication
Each new daughter helix contains an intact strand from the parent helix and a newly synthesized strand.
The degeneracy or redundancy of the genetic code refers to
the fact that most amino acids have more than one codon specifying them
RNA contains __________ instead of______________
uracil
thymine
mRNA
Messenger RNA
Carries DNA complement and transports it from nucleus to ribosomes
Monocistronic
Monocistronic
One mRNA strand codes for one polypeptide
tRNA
Transfer RNA
Small RNA in cytoplasm which aids translation of mRNA's nucleotide code into a sequence of amino acids- brings amino acids to ribosomes during protein synthesis.
40 known types of tRNA
rRNA
Ribosomal RNA
structural component of ribosomes. Most abundant type of RNA. Synthesized in nucleolus
How does tRNA's structure aid the process of translation?
One end contains a three-nucleotide sequence (the anticodon) and the other end is the site of amino acid attachment
Aminoacyl-tRNA synthetase
Enzyme with an active site that binds to both the amino acid and its corresponding tRNA catalyzing their attachment to form an aminoacyl-tRNA complex.
used in translation
Ribosome- Composition
Two subunits that bind during protein synthesis.
Four binding sites
What are the four binding sites of ribosomes?
one for mRNA
three for t RNA- A, P and E
A site binds to incoming aminoacyl tRNA
P site binds to tRNA attached to growing polypeptide chain
E site binds a free tRNA before it exits the ribosome
In polypeptide synthesis, ribosome binds to mRNA near
5' end
Start codon
AUG
Termination codon
UAA
UAG
UGA
Nucleoid
In bacteria
Single circular chromosome can be found here.
Plasmids
Small circular rings of DNA found in many bacteria.
Episomes
plasmids capable of integration into the bacterial genome.
DNA is synthesized in_____________ dirction
5' to 3'
Bacterial cells reproduce by
binary fission
Transformation
Creates genetic variance in bacteria
A foreign chromosome fragment is incorporated into the bacterial chromosome via recombination
Conjugatoin
Creates genetic variance in bacteria
Transfer of genetic material between two temporarily joined bacteria.
Cytoplasmic conjugation bridge forms and genetic material is transferred from + type to - type
F Factor
Sex factor in bacteria
Plasmid that is necessary for conugation from F+ to F-
Transduction
Creates genetic variance in bacteria
Fragments of the bacterial chromosome accidentally become packaged into viral progeny produced during infection.
Recombination
Creates genetic variance in bacteria
Linked genes are separated- breakage and rearrangement of adjacent regions of DNA when organisms carrying different genes for the same traits are crossed
Operon
Found in bacterial cells
Consists of structural genes, an operager gene, and a promoter gene
Directs transcription
Structural genes code for
proteins
Operator genes code for
nothing- nontranscribable
Promoter gene codes for
nothing- initial binding site for RNA polymerase
Regulation in bacteria is via ______________ systems or ________________ systems
inducible
repressible
Inducible systems of regulation
in bacteria
require presence of an inducer
Repressible systems of regulation
In bacteria
In a constant state of transcription unless a corepressor is present to inhibit transcription
Bacteriophage
A virus that infects its host bacterium by attaching to it, making a hle and injecting its DNA
Lytic Cycle
The phage DNA takes control of bacterium's genetic machinery. Bacterial cell bursts releasing new virions which can infect other bacteria.
Lysogenic Cycle
If bacteriophage doesn't lyse host cell, it becomes integrated into bacterial genome. Virus can stay integrated or the provirus can reemerge and enter lytic cycle
Where does fertilization occur?
the lateral, widest portion of the oviduct when the sperm encounters an egg
Cleavage in embryonic development
A series of rapid mitotic divisions which lead to an increase in cell number creating progressively smaller cells.
Indeterminate vs. Determinate cleavage
Indeterminant- results in cells that maintain the ability to develop into a complete organism
Determinate- results in cells whose future differentiation pathways are determined at an early developmental stage
Morula
Solid ball of embryonic cells that forms through cleavage
Blastulation
Morula develops fluid-filled cavity called blasteocoel which becomes a hollow sphere of cells called the blastula
Ectoderm
Integuement
Endoderm
Epithelial lining of digestive/respiratory tracts
Mesoderm
Musculoskeletal system, circulatory system, excretory system, gonads and connective tissue and parts of digestive/respiratory organs
Chorion
Lines inside of egg shell. moist membrane that permits gas exchange
Egg membrane
Allantois
Egg membrane
Sac-like structure involved in respiration and excretion
Amnion
Egg membrane
Encloses amniotic fluid
Yolk Ssac
Egg membrane
Encloses yolk. Blood vessels in yolk sac transfer food to the developing embryo
marsupials develop in the mother without a
placenta
Circulation in protozoans happens by
Simple diffusion within the cell
Circulation in cnidarians happens by
Simple diffusion- body walls are two cells thick
Circulation in Arthropods happens by
Open circulatory system
In an open circulatory system
Blood is in direct contact with the body tissues and is circulated by body movements.
Blood flow in open circulatory system is
through dorsal vessel into sinuses
Circulation in annelids happens by
a closed circulatory system
How does a closed circulatory system work?
Blood is confined to blood vessels and moves towards the head in the dorsal vessel which functions as the main heart by coordinated contractions. Five aortic loops connect the dorsal vessel to the ventral vessel and act as additional pumps
Aortic loops
five pairs of vessels found in closed circulatory systems that connect the dorsal vessel tot he ventral vessel and function as pumps
Annelids are (what animal?)
earthworms
Human cardiovascular system is composed of
muscular four-chambered heart, a network of blood vessels and blood.
In the human cardiovascular system, blood is pumped into
the aorta
In the human cardiovascular system, blood is pumped from the aorta to
a series of arteries
Blood goes from the arteries
to arteriole
Blood goes from arterioles to
microscopic capillaries
Where does exchange of gases, nutrients and cellular waste products (through diffusion) take place in the human circulatory system?
In the capillaries
Blood goes from the capillaries to
the venules
blood goes from the venules
to the veins
blood goes from the veins
to the heart
Blood travelling in the veins is different than blood travelling through the arteries because it is
deoxygenated
The right side of the heart pumps _________ blood into _________ circulation
deoxygenated
pulmonary
The left side fo the heart pumps __________ blood into _________ circulation
oxygenated
systemic
Pulmonary circulation is
twoard the lungs
Systemic circulation is
throughout the body
The two upper chambers of the heart are called
atria
The two lower chambers of the heart are called
ventricles
What are the three types of blood vessels?
Arteries
Veins
capillaries
Arteries are
Thick walled, muscular
Transfer deoxygenated blood away from the heart
Which arteries DO NOT transer deoxygenated blood away from the heart?
Pulmonary arteries- transfer deoxygenated blood from the heart to the lungs
Veins are
thin walled, inelastic
Conduct deoxygenated blood towards the heart
Which veins don't transfer blood toward the heart?
Pulmonary veins transfer oxygenated blood from the lungs to the heart
Capillaries have
smallest diameter of three types of blood vessels and red blood cells travel through in single file
lymphatic System
Secondary circulatory system distinct from cardiovascular circulation
Lymphatic System transfers
interstitial fluid (lymph) to the cardiovascular system keeping fluid levels in the body constant
lymph nodes (function)
Contain phagocytic cells that filter the lymph and remove/destroy foreign particles
Composition of blood
55% liquid
45% cellular componenets
Plasma is
the liquid portion of the blood
Erythrocytes
Red blood cells
Each one can bind to up to four molecules of oxygen.
Formed from stem cells in bone marrow
Oxyhemoglobin
Hemoglobin bound to oxygen
Leukocytes
White blood cells
Larger than erythrocytes
Protective functions
Macrophages
Stationary leukocytes that have migrated from blood to tissue.
Lymphocytes
Lymphocytes that are involved in immune response and the production of antibodies
Platelets
Cell fragments (no nuclei)
Form clots- injury repair
Leukocytes are the main component of
the immune system
Hemoglobin binds to both
O2 and CO2
Where are amino acids and simple sugars absorbed into the bloodstream?
Intestinal capillaries
Where do metabolic waste products enter the blood stream?
Through capillaries throughout the body
How does clotting happen?
Platelets release a chemical to allow platelet plug formation
Thromboplastin is released- converts inactive protein prothrombin into thrombin
Thrombin converts firinogen into fibrin
Fibrin threads coat damaged area trapping blood cells to form a clot.
Humoral Immunity
Defense mechanism that involves the production of antibodies specific to the antigen involved.
Cell-mediated Immunity
Defense mechanism.
Involves cells that combat fungal and viral infection
Humoral and cell-mediated immunity is conducted by
Lymphocytes
Antibodies/Immunoglobulins
Complex proteins that recognize and bind to specific antigens triggering removal by immune system
What are the two ways that antibodies deal with antigens?
Attract other cells (like leukocytes) to phagocytize the antigen
Cause antigens to clump together and form large insoluble complexes, facilitating removal by phagocytic cells
Active Immunity
Production of antibodies during immune response. Can be conferred by vaccination
Vaccination
Injection of a weakened form of an antigen that stimulates the immune system to produce antibodies
Passive Immunity
Transfer of antibodies produced by another individual or organism. Acquired passivley or by injection
Gamma globulin
Uses passive immunity to confer temporary protection against hepatitis
Five nonspecific defense mechanisms of human body?
Skin
Mucous-coated epithelia lined passages
Macrophages
Inflammatory response
Interferons
Mucous coated epithelia
Nonspecific defense mechanism of body.
Lines passages in body and filters/traps foreign particles
Macrophages
Engulf and destroy foreign particles
Nonspecific defense mechanism of body
Inflammatory Response
Nonspecific defense mechanism of body
Injured cells release histamine making blood vessels dilate increasing blood flow to damaged region.
Granulocytes phagocytize antigenic material.
Interferons
Nonspecific defense mechanism of human body
Produced when cell is under viral attack
Diffuse to other cells preventing spread of the virus
Allergic REaction
Inappropriate responses to certain foods/pollen causing body to form antibodies and release histamine.
How does the body accept transplants?
Immuno-suppressing drugs can be used do decrease likelihood of rejection
What are the two groups of red blood cell antigens?
ABO group and the Rh factor
Type AB blood is
universal recipient
Type O blood is
Universal donor
Erythroblastosis Fetalis
When a fetus has severe anemia
When an Rh- woman carries an Rh+ fetus and the anti-Rh antibodies destroy fetal red blood cells
Translocation
Circulation in plants
What is the primary organ of transport in the plant?
The plant stem
Vascular bundles
Found in plant stems
Contain xylem, phloem and cambium cells
Xylem cells are
Thick-walled, often hollow
Located on the inside of the vascular bundle.
Carry water and minerals up the plant
What are the two types of xylem cells?
Vessel cells
Tracheids
How does water rise in the xylem?
transpiration pull, capillary action and root pressure
Transpiration Pull
as water evaporates from the leaves of plants, a vacuum is created which pulls water up the stem
Capillary Action
Any liquid in a thin tube rises due to surface tension of liquid
Root Pressure
Water entering root hairs pushes water up stem
Phloem Cells
Thin-walled cells on outside of vascular bundle
Transport nutrients down the stem
Sieve tube cells and companion cells are part of
Phloem cells in plants
Cambium Cells
Two layers thick.
Actively dividing and undifferentiated cells that give rise to xylem and phloem
Found between xylem and phloem cells in plant stem
Structure of stem from outside to inside
Epidermis
Cortex
Phloem
Cambium
Xylem
Pith
Fibrovascular Bundle
In plant stem
Phloem, cambium and xylem layers
What is the role of a plant root?
Absorbs material through root hairs and anchors the plant.
Store energy
Root hairs
Specialized cells of root epidermis- increase surface area for water absorption
Layers of the root?
Same as layers of the stem:
Epidermis
Cortex
Phloem
Xylem
Cambium
Meristem
Actively dividing, undifferentiated cells of the plant
Cambium
Found between phloem and xylem. A type of meristem- lateral meristem providing lateral growth of stem by adding to phloem or xylem.
Apical Meristem
At the tips of roots and stems. Division leads to increase in length, elongating new cells which differentiate into specialized cell of plant
Hormones
Synthesized and secreted by endocrine glands into the circulatory system.
What determines the specificity of hormonal action?
The presence of specific receptors on or in target cells.
Adrenal Glands- location and components
Top of kidneys
Consist of adrenal cortex and adrenal medulla
ACTH- What does it do? Where does it come from?
Produced by anterior pituitary
Stimulates adrenal cortex to synthesize/secrete steroid hormones
Corticosteroids- What are they?
Collective name for steroid hormones
Glucocorticoids- What do they do? Examples
Glucose regulation and protein metabolism
Cortisol and cortisone
Glucocorticoids raise blood glucose levels by
promoting protein breakdown and gluconeogenesis and decreasing protein synthesis
Mineralocorticoids- what do they do?
Regulate plasma levels of sodium and potassium= regulate total extracellular water volume
How does aldosterone control both blood volume and blood pressure?
It can cause active reabsorption of sodium and passive reabsorption of water causing both blood volume and blood pressure to rise
What happens when there is excess production of aldosterone?
Excess retention of water which in turn causes hypertension (high blood pressure)
Androgens- What? From where?
Male sex hormones secreted by adrenal cortex. Produced by testes
What happens when there is overproduction of adrenal androgens in females?
Maculinizing effects- like facial hair
Epinephrine- what? from where?
Adrenaline. Produced by adrenal medulla.
Norepinephrine- what? from where?
Noradrenaline produced by adrenal medulla
Catecholamines- what? examples
Class of amino-acid derived compounds
Epinephrine and norepinephrine- both produced by adrenal medulla
What do epinephrine and norepinephrine do to effect blood flow in the body? What is this called?
They increase the rate and strength of the heartbeat and dilate and constrict blood vessels to increase blood supply to skeletal muscle, the heart, the brain and decrease blood supply to the kidneys, skin and digestive tract.
Fight or flight response
What stimulus releases epinephrine?
Stress
ACTH- what? what does it do? where does it come from?
Adrenocorticotrophic hormone secreted by the anterior pituitary gland. Stimulates production of glucocorticoids and sex steroids
Pituitary gland- structure and location
Small, tri-lobed gland near base of brain
Hyphophysis gland is?
Pituitary gland
Anterior Pituitary- what does it do?
Synthesizes direct hormones and tropic hormones
What regulates the secretions of the anterior pituitary gland?
Hypothalamic secretions called releasing/inhibiting hormones or factors
Tropic Hormones- What do they do? Where
Stimulate other endocrine glands to release hormones.
Found in anterior pituitary
Direct Hormones- what do they do? Where?
Stimulate their target organs directly
Found in anterior pituitary
Growth Hormones- What do they do? Where?
Promote bone and muscle growth. Direct hormone found in anterior pituitary
Prolactin- What does it do? Where?
Stimulates milk production and secretion in female mammary glands.
Direct hormone found in anterior pituitary
What causes dwarfism?
Growth hormone deficiency in children causing stunted growth.
Gigantism- cause?
Overproduction of growth hormones in children
What causes acromegaly?
Overproduction of growth hormones in adults
Endorphines- What does it do? Where?
Inhibit perception of pain
Direct hormones produced by anterior pituitary
Andrenocorticotropic Hormone (ACTH)- What does it do? Where?
Stimulates adrenal cortex to synthesize and secrete glucocorticoids. Regulated by corticotrophic releasing factor
Tropic hormone produced by anterior pituitary
Thyroid-stimulating Hormone- What does it do? Where?
Stimulates the thyroid gland to synthesize and realize thyroid hormone
Tropic hormone produced by anterior pituitary.
Luteinizing Hormone- What does it do? Where?
Stimulates ovulation and formation of the corpus luteum in females.
Stimulates interstitial cells of the testes to synthesize testosterone in males
Tropic hormone produced by anterior pituitary
Follicle Stimulating Hormone
Causes maturation of ovarian follicles causing estrogen secretion in females
Stimulates maturation of seminiferous tubules in males
Tropic hormone produced by anterior pituitary
Melanocyte-Stimulating Hormone- What does it do? Where?
Secreted by intermediate lobe of pituitary. In frogs it causes darkening of skin
Tropic hormone produced by anterior pituitary
Neurohypophysis
Posterior pituitary gland
What does the posterior pituitary gland do?
tores and releases peptide hormones oxytocin and ADH
What produces oxytocin and ADH
Neurosecretory cells and the hypothalamus
Oxytocin- What does it do? How?
Increases strength and frequency of uterine muscle contractions.
Induced by suckling- stimulates milk secretion in mammary glands.
Antidiuretic Hormone- What does it do? When is it secreted?
ADH
Increases permeability of nephron's collecting duct promoting water reabsorption and increasing blood volume
Secreted when plasma osmolarity increases or when blood volume decreases
Hypothalamus- location
Part of forebrain located directly above pituitary gland
What does the hypothalamus do?
Receives neural transmissions from other parts of the brain and from peripheral nerves that trigger specific responses from its neurosecretory cells.
How do neurosecretory cells regulate the pituitary gland?
Via negative feed back mechanisms and through inhibiting and releasing hormones
What are hypothalamic releasing hormones?
Hormones that stimulate or inhibit the secretions of the anterior pituitary
GnRH- What is it?
Stimulates anterior pituitary to secrete FSH and LH
Hypothalamic releasing hormone
Path of hypothalamic releasing hormones
Releasing hormones are secreted into the hypothalamic-hypophyseal portal system where bloo fromt he capillary bed in the hypothalamus flows through a portal vein into the anterior pituitiary where it diverges into a second capillary network. This allows releasing hormones to immediately reach the anterior pituitary
How does the hypothalamus interact with the posterior pituitary?
Neurosecretory cells in hypothalamus synthesize oxytocin and ADH and transport them into posterior pituitary for storage and secretion
Thyroid Gland- Structure and Location
Located on ventral surface of trachea
What does the thyroid gland do?
Produces and secretes thyroxin, triidothyronine and calcitonin
Thyroxine and Triidothyronine- What does it do?
Derived from amino acid tyrosine
Necessary for growth and neorological development in children
Increase rate of metabolism throughout body
Hypothyroidism- Cause? Symptoms?
Thyroid hormones are undersecreted
Slowed heart rate and respiratory rate, fatigue, cold intolerance and weight gain
Cretinism
Hypothyroidism in newborns causes mental retardation and short stature
Hyperthyroidism
Thyroid is overstimulated resulting in oversecretion of thyroid hormones causes increased metabolic rate
Calcitonin
Decreases plasma Ca2+ concentration by inhibiting its release from the bone.
Regulated by plasma Ca2+ levels
Pancreas- what is it?
Both an exocrine organ and an endocrine organ
What is the exocrine function of the pancreas?
Performed by cells that secrete digestive enzymes into small intestine via ducts
What is the endocrine function of the pancreas?
Performed by small glandular structures called the islets of Langerhans
Islets of Langerhans
Part of endocrine function of pancreas.
Composed of alpha and beta cells
What do alpha cells do (in islets of Langerhans)?
Produce and secrete glucagon
What do beta cells do (in islets of Langerhans)?
Produe and secrete insulin
Glucagon- what does it do?
Stimulates protein and fat degradation, conversion of glycogen to glucose and gluconeogenesis which all increase blood glucose levels.
Insulin- what does it do?
Protein hormone that's secreted in response to a high blood glucose concentration
How does insulin work?
Stimulates the uptake of glucose by muscle and adipose cells and the storage of glucose as glycogen in muscle and liver cells.
Stimulates synthesis of fats from glucose and the uptake of amino acids
Diabetes Mellitus
Underproduction of insulin causing hyperglycemia
Parathyroid Glands- structure
Four small pea-shaped structures in the posterior surface of the thyroid.
What do the parathyroid glands do?
Synthesize and secrete parathyroid hormone which regulates plasma Ca2+ concentration
How does PTH ragulate plasma Ca2+ concentrations?
Stimulates Ca2+ release from bone and decreases Ca2+ excretion in kidneys
Kidneys- function
Produce renin when blood volume falls
What does renin do?
Enzyme that converts plasma protein angiotensinogen to angiotensin I which is converted to antiogensin II which stimulates adrenal cortex to secrete aldosterone.
What does aldosterone do?
Helps restore blood volume by increasing sodium reabsorption at the kidney leading to an increase in water removing initial stimulus for renin production
Gastrin
Hormone that is released when food is ingested. After realease it is carried to gastric glands where it stimulates the glands to secrete HCl in response to food in the stomach.
Secretin
Hormone that is released by small intestine when acidic food material enters the stomach. Stimultes secretion of solution that neutralizes the acidity of the chyme (partially digested food)
Cholecystokinin
Hormone released by small intestine in response to presence of fats that causes gall bladder contraction and release of bile
Bile
Involved in fat digestion
Pineal Gland
Structure at base of brain that secretes melatonin which plays a role in circadian rhythms
S
Melatonin secretion is regulated by
light and dark cycles
What are teh two major groups of hormones?
Peptide
Steroid
How do hormones effect the activities of their target cells?
Extracellular receptors
Intracellular receptors
Peptide Hormones
Act as first messengers that bind to specific receptors on the surface of their target cells triggering enzymatic reactions in each cell.
Cyclic AMP
Relays messages from extracellular peptide hormone to cytoplasmic enzymes initiating reactions inc ell
Seroid Hormones
Produced by testes, ovaries, placenta and adrenal cortex.
Lipid soluble- enter target cells directly and bind to specific receptor proteins in cytoplams. Receptor hormone complex enters nucleus and activates expression of specific genes by binding to receptors on chromatin inducing a change in mRNA transcription
What produces plant hormones?
ACtively growing parts of the plant like the meristematic tissues in the apical region
Phototropism
Tendency of shoots of plants to bend toward light source. Controlled by auxins.
Indoleacetic acid
One of the auxins associated with phototrophism
Geotropism
Growth of portions of plants away or towards gravity
Negative Geotropism
Causes shoots to grow upward and away from acceleration of gravity
Positive Geotropism
Causes roots to grow towards the pull of gravity
Auxin inhibition of lateral buds
Auxins produced in terminal bud of a plant's growing tip move downward in the shoot and inhibit development of later bud
Gibberellins
Stimulate rapid stem elongation particularly inplants that don't grow tall.
Inhibit formation of new roots and stimulate production of new phloem cells by cambium
Terminate dormancy of seeds and buds
Kinins
Promote cell division
Ratio of kinetin to auxin
determines timing of differentiation of new cells
Ethylene
Stimulates fruit ripening and induces aging in plants
Inhibitors
Block cell division- growth regulation. Important to maintenance of dormancy in lateral buds and seeds of plants
Abscisic acid
One of the most important inhibitors in plants
Anti-Auxins
Regulate activity of auxins
Indoleacetic Acid concentration regulation
Controlled by indoleacetic acid oxidase. Increase in idoleacetic acid increases amoutn of indoleacetic acid oxidase produced.
Nervous System- role
Allows organism to receive and respond to stimuli from external and internal environments
Neurons
Functional units of nervous system
Convert stimuli into electrochemical signals that are conducted through the nervous system
Structure of a neuron
Elongated cell made of several dendrites, a cell body and an axon.
Dendrites
Cytoplasmic extensions that receive information and transmit it toward the cell body.
Part of the neuron
Axon
Part of neuron
Long cellular process that transmits impulses away from cell body
Myelin
Substance that sheaths most mammalian axons
Allows axons to conduct impulses faster
Produced by glial cells
What produces myelin?
Oligodendrocytes and Schwann cells
Nodes of Ranvier
Gaps between segments of yelin
Neurotransmitters
Are released from synaptic terminals on axons into synapse
Synapse
Gap between axon terminals of one cell and the dendrites of the next cell
Neuron- Function
Receive signals from sensory receptors or other neurons and transfer information along length of axon
Action Potentials
Impulses that travel through neurons and invade the nerve terminal causing neurotransmitter release
Resting Potential
Potential difference between the extracellular space and intracellular space when neuron is at rest due to unequal distribution of ions.
A typical resting membrane potential is
-70 millivolts- inside of neuron is more negative
Why is the inside of a neuron more negative?
Na+/K+ pump makes K+ concentration higher inside the neuron. K+ diffuses down concentration gradient leaving a net negative charge inisde
How is the concentration gradient in the neuron restored?
Na+/K+ pump transports three Na+ out for every two K+ transported into cell
Action Potential
Generated when neuron becomes sufficiently excited or depolarized and the inside becomes more negative. In response to depolarization, voltage gated Na+ channels are opened depolarizng a segment of the cell and then close. Voltage-gated K+ channels open allowing K+ to rush out down its electrochemical gradient- repolarization= making cell more negative. Cell enters refractory period right after because it is difficult for it to initiate another action potential
All-or-none Response
When the threshold membrane potential of a neuron is reached, an action potential with a cosnistent size and duration is produced
What direction does information transfer occur in?
From dendrite to synaptic terminal
The greater the diamter of an axon,
the faster the impulses travel
Synapse
Gap between the axon terminal of one neuron (the presynaptic neuron) and the dendrites of another neuron (postsynaptic neuron)
Effector Cells
Cells other than neurons that neurons communicate with like muscles or glands
Neurotransmitters
Membrane-bound vesicles full of chemical messengers
Curare
Blocks post-synaptic acetylcholine receptors so that acetylcholine is unable to interact with the receptor leading to paralysis
Botulism Toxin
Prevents release of acetylcholine from presynaptic membrane- results in paralysis
Anti-cholinesterases
Inhibit activity of acetylcholinesterase enzyme. Prevents coordinated muscular contractions from taking place
Protozoa- Nervous system?
No organized nervous system
Cnidaria
Simple nervous system called nerve net
Annelida- Nervous system?
Central nervous system consisting of devined ventral nerve cord, anterior brain of fused ganglia adn definitive nerve pathways from receptors to effectors
Arthropoda- Nervous system?
Similar brains to those of annelids but more specialized sense organs
Afferent Neurons
Carry sensory information
Efferent Neurons
Carry motor commands
Interneurons
Participate only in local circuits linking sensory and motor neurons in brain and spinal cord
Plexus
Network of nerve fibers
Ganglia
Neuronal cell body clusters
Central nervous system consists of
brain and spinal cord
Brain functions
Interpreting sensory information
Forming motor plans
Cognitive function
Brain structure
Outer portion called gray matter
Inner white matter
Components of forebrain
TelencephalonDiencephalon
Cerebral cortex
Major component of telencephalon
Highly convoluted gray matter
Can be seen on surface of brain
Olfactory Bulb
Center for reception and integration of olfactory input
Diencephalon
Thalamus and hypothalamus
Thalamus
Relay and integration center for spinal cord and cerebral cortex
Hypothalamus
Controls visceral functions like hunger, thirst, sex drive, water balance, blood pressure, temperature regulation
Controls endocrine system
Midbrain
Relay center for visual and auditory impulses
Plays role in motor control
Mesencephalon
Midbrain
Hindbrain
Posterior part of brain. Consists of cerebellum, pons and medulla
Cerebellum
Modulates motor impulses initiated by cerebral cortex. Important in maintaining balance, hand-eye coordination and timing of rapid movements
Pons
relay center to allow cortex to communicate with cerebellum
Medulla
Controls vital functions like breathing, heart rate, gatrointestinal activity
Brainstem
Midbrain
pons
Medulla
Spinal Cord
Conduit for sensory information to brain and motor information from brain
Integates reflexes by itself
Consists of outer white matter area of motor and sensory axons and inner gray matter area containing nerve cell bodies
Dorsal Horn
Sensory info. enters spinal cord from here
Ventral Horn
All motor information exits spianl cord from here
Peripheral Nervous System
Consists of nerves and ganglia, sensory nerves that enter CNS and motor nerves that leave CNS
Somatic Nervous System
Innervates skeletal muscles and is responsible for voluntary movement
Autonomic Nervous System
Regulates body's internal environment without conscious control
Innervates cardiac and smooth muscle.
Important in blood pressure control, gastrointestinal motility, excretory processes, respiration and reproductive processes
Sympathetic Nervous System
Responsible for fight or flight responses. Increases blood pressure and heart rate. Increases blood flow to skeletal muslces and decreases gut motility. Dilates bronchiles to increase gas exchange. Uses norepinephrine as primary transmitter
Parasympathetic Nervous System
Acts to conserve energy and restore body to resting activity levels following exertion. Lowers heart rate, increases gut motility
Vagus Nerve
Importan nerve of parasympathetic nervous system.
Myopia
Nearsightedness
Image is focused on front of retina
Hyperopia
Farsightedness
Image is focused behind retina
Astigmatism
Caused by irregularly shaped cornea
Cataracts
Develp when lens becomes opaque and light cannot enter- blindnes
Glaucoma
Increase in pressure in eye due to blocking of outflow of aqueous humor
External Respiration
Entrance of air into lungs and gas exchange between alveoli and blood
Internal Respiration
Exchange of gas between blood and cells and intracellular processes of respiration
Dehydrogenation
High energy H atoms are removed from organic molecules during respiration
Glycolysis
First stage of glucose catabolism. Series of reactions that lead to oxidative breakdown of glucose into two pyruvate molecules, ATP, reduction of NAD+ into NADH
Takes place in cytoplasm