Coagulation Modifier Drugs: Chapter 28

Front 1

The two major pathways

Back 1

Intrinsic pathway and extrinsic pathway. the pathways are set separate cascades but both converge at a common point.

Front 2

The four coagulation drugs

Back 2

1. Anti-coagulants: inhibits clotting factors

2. Anti-platelet: prevents platelet plug

2. Ant-fibrinolytic: promotes blood coagulation

4. Thrombolytic Drugs: breaks down the clot

Front 3

Anti-coagulants:

Back 3

They prevent the formation of a clot by inhibiting certain clotting factors in both pathways. no direct effect on formed clot. They are used to treat strokes, MI, DVP, unstable angina, atrial fibrillation and open heart surgery. Watch for allergies and uncontrolled bleeding., pregnancy, surgery and leukemia, vitamin K, aspirin , sulfonamides and analgesics.

Front 4

Heparin VS. Warfarin

Back 4

Heparin: inhibits activity of clotting factors suppressing the formation of the clot, short half-life (1-2hrs). Safe for pregnancy because it doesn't cross the blood brain barrier. Goes by weight in units.

Warfarin: inhibits synthesis of clotting factors, long term and taken orally.

Front 5

Anti-Platelet

Back 5

Prevent platelet adhesion to the site of blood vessels injury, which occurs before the clotting cascade. Used to prevent stokes, transient ischemic attack, MI, coronary bypass grafting. Monitor for allergy, thrombocytopenia, active bledding, leukemia, traumatic injury, GI ulcer, vitamin K