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16 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Anticoagulants |
Inhibit/ prevent the action or formation of clots -strokes -myocardial infraction -deep thrombosis -pulmonary embolism |
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Anticoagulants MOA |
-Varies on drug -Does not lyse existing clots -Works on different points of clotting cascade |
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Anticoagulant drugs |
Heparin Low-molecular-weight Heparin -Enoxaparin -Dalteparin Fondaparinux Warfarin
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6 drugs |
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Anticoagulant Indications: Heparin |
-Monitored by activated partial thromboplastin time (aPTT) -short half life -effects reversed by Protamine Sulfate -turn off coagulation pathways and prevent clot formation |
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Anticoagulant Indication: Warfarin |
-Vitamin K administered if toxicity occurs -monitored by prothrombin time ( PT) or INR (PT-INR) -given orally only |
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Anticoagulant Drugs/Indications: LMWH |
Enoxaparin Dalteparin -More predictable anticoagulant response -given subcutaneously -do not require frequent lab monitoring |
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Antiplatelet Drugs |
Aspirin Dipyridamole
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2 drugs |
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Antiplatelet Drugs: APD inhibitors
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Clopidogrel Ticlopidine |
2 drugs |
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Antiplatelet Drugs: Glycoprotein 2b/3a inhibitors |
Tirofiban Eptifibate Abciximab |
3 drugs |
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Antiplatelet MOA |
Prevent platelet adhension |
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Antiplatelet: Indications |
Antithrombotic effects, reduce risk of fatal and non fatal strokes, acute angina, and MI |
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Antifibrinolytic Drugs |
Aminocaproic acid Desmopressin -similar to ADH -treats diabetes insipidus |
2 drugs |
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Antifibrinolytic Drugs: Indication |
Prevent/treat excessive bleeding -hyperfibrinolysis -surgical complications -excessive oozing from surgical sites, i.e chest tubes -reduce total blood loss/duration of bleeding in postoperative period Treatment of hemophilia or Von Willebrands disease |
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Thrombolytic Drugs |
Streptokinase Urokinase Tissue plasminogen activator (t-PA) Anisoylated plasminogen-streptokinase activator (APSAC) Anistreplase Alteplase Reteplase Tenecteplase |
8 drugs |
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Thrombolytic Drugs MOA |
-Activate fibrinolytic system to break clots down in blood vessel quickly -Activate plasminogen, convert to plasmin which digest fibrin - Reestablish blood flow to heart muscles via coronary arteries preventing tissue destruction |
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Thrombolytic Drugs: Indications |
Acute MI Arterial thrombosis DVT Occlusion of shunts or Catheters PE Acute ischemic stroke |
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