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80 Cards in this Set
- Front
- Back
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characterized by the malignant transformation of developmentally pluripotent myeloid stem cells and their linage restricted descandants. |
Myeloproliferative Disorders |
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Name the 4 types disorders of Myeloproliferative Disoders. What can any of them turn into? |
Myelofibrosis Polycythemia Vera Thrombocythemia Essential CML
AML = Acute Myeoblastic Leukemia |
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CML effectts (Chronic myelogenois Leukemia) |
NEB(usually N) |
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Polycythemia Vera effects |
all cells proliferating usually RBC |
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describe myelofribosis and what does it lead to? |
overproduction of connective tissue in bone marrow which leads to myeloid dysplastic syndrome |
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in myeloproliferative disoder, all hypercellurate except |
myelofirbirosis |
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all 4 disorders of myeloproliferative disorder sideeffect? |
hepato and spleenomeagly due to extramedullary hemtopsoeisis |
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hyperviscosity and peripheral blood abnormalities via myleoprolif disorder except for.... |
myelofirbrosis |
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characterized by ineffective hemtopoisis and pancytopenia |
Myelodysplastic syndrome |
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"pre leukemia" |
Myeolodysplastic syndrome(MDS) |
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are diverse collection of hematological condition united by ineffective produciton of blood cells and varying risks of transformation to AML. |
mds |
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bone marrow stem cell disordres resultin gin disorderly and ineffective hematopoiesis manifestd by irreversible quant and qual defects |
mds |
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1/3 of mds progresses to |
AML |
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2 most serious complication s of MDS |
bleeding and Infection |
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abnormal cells get out of bone marrow |
myeloproliferative |
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abn cells ddon't get out of bone marrow |
mds |
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suffer from Iron Overload |
mds |
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Anemia is another side effect oof Myelodysplastic syndrome |
freebie |
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anemia, neutropenia, thrombocytopenia
specific to mds?
which one is most common? |
noooo
anemia |
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is MDS risk of death usually to potential AML or from cytopenias seen in mds? |
cytopenia |
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list the causes of Leukemias |
A CHIME
alkylating agent
Chromosal defects - down syn HTLV - leads to T cell Ionizing radiation MDS Endogenous Factor - Philchrom 9 -22 |
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80% of acute leaukemai in adults |
AML |
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+20% myeloblasts in BM |
AML |
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has 2 types name em
aml, cml,all, or cll? |
AML
denova and End stage |
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"more myeloid precurso"
myeloid cells |
CML |
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Philadelphia chromosome |
CML |
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prominent splenamegolo > hepato and or adeno |
CML |
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terminated in "blast crisis" |
CML |
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most common among children |
ALL |
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+30% lymphoblast |
ALL |
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prognosis inverse to age |
ALL |
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+40% lmyphoid cells |
CLL |
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resmebles b lymphocyes and infiltrates marrow |
CLL |
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Indolent for 7-10 years and |
CLL |
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lymphodepathy common |
CLL |
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auer rods
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AmL
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multiple myeloma is which type of disoder? which cell? |
plasma cell disorder IgM |
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a malignancy of plasmacytoid lymphocyes that secrete M resulting in HYPERVISCOSITY SYNDROME with RENAL, RETINAL, AND CEREBRAL ISCHEMIA as a result of microvascular occlusion. |
Waldenstrom Macroglobulinemia |
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Deposition of light or heavy chains that form amylodi deposit? |
light |
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hyper or hyp calcemia for mm? |
hypercal |
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increase in what shows evidence of renal failure? |
BUN |
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Most common cause of death of mm |
renal failure due to deposit of proteins |
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Bence jones protien where? |
mm in urin |
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thrombocytopenia or thrombocytosis in mm? |
penia |
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osteoblast or osteoclast in mm? |
osteoclast |
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Most common ab invovled in MM?
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IgM
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more common non hodg or hodking? |
non hodkin |
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predisoposing factors |
orei
oncgens radiation environmenta factor - burkits lymphomoa ebv immunodic- hiv associdte cns lymphomas |
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heterogenous group of neoplasms arising from both t and b cells and precrussos |
non hodgkin |
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with non hodgkin where most common and which cell? |
lymph node and b cells |
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STARTS IN LYMPH NODE = LYMPHOMA IF CANCER STARTS IN BLOOD = LEUKEMIA |
FREEBIE |
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name the 4 types of non hodgkins |
precur b precu t peripheral b cel burkit lymphoma |
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btwn precur b and t which on responds better to treatment |
b |
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peripher b cell affect which age group and are they bening or malignant |
adults malignant |
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lymphoma equivalent to CLL |
small cell |
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lymphoma that affects elderly |
follicular |
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mantle cell is what type |
non hodgkin peripiral b cell |
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70% of all aggresive lymphoma |
diffuse b cel |
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results in peripheral blood low ground lymphoma |
hairy cell leukemia |
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this lympoma is associated with Spleenomegaly
it's a non hodgkins |
hairy cell leukemia |
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related to EBV |
Burkit lymphoma |
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burkit lymph - solid tumor
afric =
us = |
afri = mandible, maxill us = abdomen |
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affected nodes show an inflammatory response to tumor cells and contain infiltrates of lymphocyes, plasma cells and esoinophils |
hodgkins |
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pathognomonic for hodgkins |
reed sternberg cells owl eyes |
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what determines the 5 types of hodgkins? |
the cells surrounding the reed stern berg cells |
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hodgkins, prognosis depends on? not on |
stage of disease at time of of diagnosis
not on histological type |
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more often localized to single axial group |
hodgkins |
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orderly spread by contiguity |
hodgkins |
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mesenterick nodes and waldeyyer rarely involved |
hodgkins |
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extranodal involvnen NOT common |
hodgkins |
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more frequent involvement of multiple peripheral nodes |
non hodgins |
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noncontigous spread |
non hod |
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waldeyer ring and mesenteri nodes INVOLVED |
non hod |
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extranodal involve COMMON |
non hodg |
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single lymp nodes region or single extra lymp |
stage 1 |
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two more more sites same side of diapgh |
stage 2 |
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both sides of diapthramg
spleen or contig lymp sites |
stage 3 |
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diffuse involvement of extralymphatic sides |
stage 4 |
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if myeloid leukemia infiltratin lymph node = lymphoma? |
NOOOO |
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read last slides and leukocytosis notes!!! |
freebie |
