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20 Cards in this Set

  • Front
  • Back
after stimulation, what actually causes an increase in contractility?
increasing the Ca+ influx
how do you increase cardiac contractility?
ANS activity
Hormones
What is the sequence of events for sympathetic stimulation of the SA node?
NE stimulates B1
G protein coupled stimulation of adnylyl cyclase
increased Na+ influx
what is the sequence of events for parasympathetic stimulation of the SA node
ACh stimulates muscarenic receptors
this inhibits adnylyl cyclase
decreased Na+ influx
how do sympathetics increase contractility?
positive inotropic effect stimulates greater Ca+ release
How do parasympathetics decrease contractility?
negative inotropic effect decreases Ca+ release
what happens to the force development over time with an increase in sympathetics to the myocardium?
the rate of rise and fall is much faster and more force is generated
what happens to the ESV and the EDV when sympathetics are increased?
EDV stays the same
ESV is decreased
what happens to the SV as sympathetics are increased?
SV increases
what is Treppe?
as HR increases, the amount of Ca+ stored in the SR increases. This allows for greater contractility and maintains CO at high HR
What happens to the EDV and SV as you increase preload?
they increase
what happens to EDV and SV as you increase contractility?
EDV stays the same
SV increases (ESV lowers)
how do you calculate Stroke Work?
LVSW= SV X LVPP
how would you determine stroke work without catheterization?
LVSW= SV X MAP
How do you calculate Mean Arterial Pressure?
MAP= DP + 1/3 PP
how do you calculate ventricular minute work?
LVMW= LVSW X HR
or
LVMW= SV X MAP X HR
how do you calculate LV work index?
LVSW/SA
how do you measure CO via the Fick method?
CO= O2 consumption/(Arterial O2 - Venous O2)
what is the average cardiac efficiency?
5 to 15%
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