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13 Cards in this Set
- Front
- Back
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The singular G2 phase drug is |
Bleomycin |
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The three anti cancer drugs that are not bone marrow toxic |
Cisplatin,bleomycin,vincristine |
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Two drugs notorious for causing pulmonary fibrosis |
Bleomycin and amiodarone |
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Principles of cancer chemotherapy |
-It destroys both the normal and cancerous cells especially fast growing normal cells like bone marrow hence anaemia,hair -Nephrotoxicity due to uric acid secretion hence cancer pts receive a great fluid therapy -Most of them are notorious for nausea and vomitting,we counter with ondansterone -We use combination therapy in order to prevent resistance |
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Growth factor receptor antagonists in ca chemotherapy include |
Cetuximab |
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The spread or metastasis inhibitors are graded into 2.They are: |
-Angiogenesis inhibitor e.g Bevacizumab Matrick metalloproteinase e.g marimastat |
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Apoptosis inducers include |
Benzthromium ,retinoic acid |
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Anti cancer agents that work on Cell cycle |
-Alkylating agents -Antimetabolites -Cell cycle inhibitors -Plant derivates |
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The classes of drug that are alkylating agents |
-Nitrogen mustards:cyclophasmide,melphlan,cholarmbucil,buslfan,cisplatin -Nitrosoureas:Lomustine,carmusitine -Platinum analogs:Cisplatin,carboplatin |
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The classes of anti metabolites include |
A.Folate antagonists:Methotrexate B.Purine analogs:Mercaptourine,thioguanine,azathioprine C.Pyrimidine analogues:Fluorouracil,cytarabine,gemeitabine |
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Moa of anti metabolites |
As the name implies,they prevent metabolic processes in dna synthesis |
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Moa of the plant derivatives |
It acts by binding to tubulin and inhibiting its polymerization into microtubule preventing spindle formation and mitosis hence arresting cell division |
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Classify the plant derivatives |
-Vinca alkaloids:Vincristine,vinblastine -Taxanes:paclitaxel -campothecins:irinotecam,topotecan,etoposide(Tie) |
