Breast - Pathology Review

Front 1

Positive stains for PASH?
Cell of origin?

Back 1

Vimentin, ACtin, ER, CD34
Cell type: Myofibroblasts

Front 2

5 features to distinguish sclerosing adenosis from tubular carcinoma?

Back 2

1 - lobulated arrangement
2 - compressed/distorted tubular lumens
3 - fibrous stroma compressing tubules
4 - two cell layers
5 - tubules invested by basement membrane

Front 3

Which breast cancers have a better prognosis?

Back 3

Medullary, Mucinous, Tubular, Solid Papillary

Front 4

EIC Definition

Back 4

DCIS present involving at least 25% of the area of invasive carcinoma and extending outside the invasive carcinoma mass

Front 5

BRCA-1 Biomarker Profile

Back 5

ER, PR, HER2 -
CK 5/6+

Front 6

Which benign breast diseases have a 1.5 to 2.0 increased chance of breast cancer?
4.0 to 5.0?

Back 6

1.5 - 2.0: Florid hyperplasia, sclerosing adenosis, papilloma, complex sclerosing lesion

4.0 - 5.0: ADH, ALH

Front 7

Five features to differentiate between benign and malignant phyllodes tumor?

Back 7

1. increased mitotic activity
2. marked atypia of stromal cells
3. stromal overgrowth
4. infiltrating margin
5. tumor necrosis and hemorrhage

Front 8

Histologic features of radial scar?

Back 8

Stellate configuration
central elastosis and fibrosis
entrapped ductules in the central scar
dilated tubules at periphery
various patterns of epithelial hyperplasia
tubules lined by 2 layers of cells

Front 9

Three benign breast conditions confused with invasive breast cancer?

Back 9

Sclerosing adenosis, microglandular adenosis, and radial scar

Front 10

Six Histologic Subtypes of DCIS?

Back 10

Solid, Comedo, Cribriform, Clinging, Papillary, Micropapillary

Front 11

Six types of IDC?

Back 11

Tubular, mucinous, medullary, invasive papillary, apocrine, metaplastic

Front 12

Luminal A phenotype?

Back 12

ER/PR +, Her 2 - good prognosis

Front 13

Luminal B phenotype?

Back 13

ER PR +, her 2 variable, not as good as A

Front 14

Her 2 phenotype?

Back 14

ER/PR - , her 2 + poor prognosis

Front 15

Basal like phenotype?

Back 15

ER, PR, HER2 - , receive platinum based chemo

Front 16

Two associated genetic abnormalities of ILC?

Back 16

LOH 16q (e-cadherin, beta catenin)
LOH 11q13

Front 17

ILC Hormone Stains?

Back 17

ER+, PR +, HER 2 -

Front 18

Paget disease stains vs Toker Cell hyperplasia

Back 18

Paget: Mucin +/-, CK7+, Cam 5.2+, EMA+, HER2 +
Toker: CK7 +/-, Mucin - , Cam 5.2 +/-, Her 2 -