Boards Hemonc

Front 1

vWD inheritance and Tx

Back 1

– AD
– FFP or cryoprecipitate for major bleeding
– DDAVP in mild
– e-aminocaproic acid in minor procedures
– avoid ASA

Front 2

Adult ITP Tx

Back 2

– ovserve if > 50
– then think prednisone (do BM bx to r/o leukemia)
– Rhogam for < 10,000
– platelets if really bad

Front 3

ALL labs

Back 3

– LDH and Uric acid are increased
– PAS, TdT, and CALLA are positive

Front 4

ALL cytogenetics

Back 4

– Phili and (4,11) are bad
– B is CD 10 (CALLA) 19 and 20
– T is 2, 5, 7

Front 5

ALL tx

Back 5

– vincristine, prednisone, daunorubicin, L-asparaginase, cyclophos
– Philadelphia chromosome is bad and needs BMT

Front 6

AML Hx

Back 6

– skin and lung infections
– leukostasis
– marrow failure but rarely HSM or LA

Front 7

AML diagnosis

Back 7

– Sudan black and myeloperoxidase
– Auer rods

Front 8

AML cytogenetics

Back 8

– (8,21) and (15,17) have a good prognosis
– monosomies do not

Front 9

AML treatment

Back 9

– Cytarabine and anthracycline
– can do stem cell
– leukopharesis is high white count
– do NOT transfuse if WBC > 50,000

Front 10

CLL hx

Back 10

– mainly B’s
– usually Asx but maybe increased infections

Front 11

CLL Dx

Back 11

– isolated lymphocytosis (RBC’s and platelets normal) up to > 100,000
– smudge cells
– cytogenetics shows CD 19 and 5
– hypogammaglobulinemia in more advanced
– low platelets is a bad sign

Front 12

CLL chemo

Back 12

– Fludarabine, unless AIHA then give Rituximab
– Chlorambucil in older pts

Front 13

CLL complications

Back 13

– AIHA and thrombocytopenia treated w/ prednisone and splenectomy
– Richter’s syndrome is transformation into large cell lymphoma

Front 14

CML hx

Back 14

- 3 phases
– chronic is increase WBCs w/ HSM
– Accerlated is decreased RBCs and platelets w/ systemic signs
– blast phase is > 20% blasts in BM

Front 15

CML dx

Back 15

– usually Philadelphia
– WBC > 150,000
– decreased LAP

Front 16

CML treatment

Back 16

– Gleevec
– IFN-a
– Hydroxyurea if they cant tolerate
– BMT if < 60 and no response to gleevec after 6 months

Front 17

Multiple Myeloma treatment

Back 17

– Thalidomide
– if refractory, do alkylating agent (melphalan or cyclo) plus prednisone or VAD (vincristine, doxorubicin, dexamethasone)

Front 18

Non-Hodgkins tx

Back 18

– CHOP
– cytoxan, adriamycin, oncovin (vincris), prednisone

Front 19

Hodgkins Tx

Back 19

– ABCV
– adriamycin, bleomycin, vincristine, dacarbazine

Front 20

Normocytic anemia causes

Back 20

– uremia
– hypothyroid
– bone marrow failure

Front 21

Burr Cell

Back 21

– seen in ARF or uremia

Front 22

Heinz Body

Back 22

– Thalasemia, SS, G6PD

Front 23

What kind of anemia does B6 deficiency cause?

Back 23

– sideroblastic w/ increased TIBC and iron

Front 24

MAHA tx

Back 24

- HUS is dialysis if ARF
– TTP is plasmapheresis w/ steroids, ASA and splenectomy
– DIC is platelets and cryoprecipitate

Front 25

Cooley’s anemia tx

Back 25

– B-thal
– transfusion, splenectomy, BMT
– deforxamine to increase iron excretion

Front 26

Polycythemia vera Tx

Back 26

– phlebotomy
– hydroxyurea for myelosupression
– ASA
– can transform to CML, AML, or myelofibrosis

Front 27

Acute vs. Chronic GVHD

Back 27

– pruritic maculopapular rash w/ HSM and diarrhea before 100 days
– keratoconjunctivitis sicca and lichenoid changes of cheek after 100 days

Front 28

GVHD Tx

Back 28

– cyclosporine
– tacrolimus
– methotrexate

Front 29

Turcot’s syndrome

Back 29

– brain tumors w/ HNPCC or FAP

Front 30

Gardner’s syndrome

Back 30

– polyps w/ desmoid tymors, cysts, lipomas, osteomas

Front 31

Cronkite-Canada syndrome

Back 31

– polyps w/ ectodermal problems

Front 32

Cowden’s syndrome

Back 32

– polyps w/ breast and thyroid cancers
– gingival hyperplasia

Front 33

Maltoma w/out mets Tx

Back 33

– just eradicate H. pylori

Front 34

Bernard Soulier

Back 34

– Giant platetes w/ mild thrombocytopenia
– won’t aggregate w/ ristocetin but normal vWF

Front 35

Glanzmann’s thromboblasthenia

Back 35

– normal count but qualitiatve problems
– abnormal ADP agglutination

Front 36

What tumors don’t go to the brain

Back 36

– skin cancer that’s not melanoma
– prostate
– esophageal
– OP cancer

Front 37

Acute cord compression from cancer mets

Back 37

– give steroids immediately

Front 38

Cancer anorexia tx

Back 38

– megestrol acetate

Front 39

Febrile neutropenia tx

Back 39

– blood culture and ceftazadine of cefepime

Front 40

Fanconi’s anemia

Back 40

– chromosomal breaks lead to macrocytic anemia
– fatigue and pounding ears
– poor growth and hypopigmented spots
– do stem cell Tx

Front 41

Hairy cell staining and Tx

Back 41

– TRAP + and treat w/ cladribine

Front 42

Paroxysmal Nocturnal Hemogolbinuria

Back 42

– membrane defect -> increased binding of compliment and hemolysis w/ hypoventilation at night
– can get hepatic vein thrombosis