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85 Cards in this Set
- Front
- Back
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HLA-A3
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Hemochromatosis
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HLA-B27
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Psoriasis, ankylosing spondylitis, inflammatory bowel disease, Reiter's syndrome
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HLA-B8
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Grave's disease
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HLA-DR2
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Multiple sclerosis, hay fever, SLE, Goodpasture's
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HLA-DR3
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DMI
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HLA-DR4
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Rheumatoid arthritis, DMI
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HLA-DR5
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Pernicious anemia, Hashimoto's thyroiditis
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HLA-DR7
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Steroid responsive nephrotic syndrome
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IL-1
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Secreted by macrophages
Causes fever, acute inflammation (activates endothelium, chemokine secretion) |
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IL-6
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Secreted by macrophages and Th cells
Causes fever and production of acute phase proteins |
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IL-8
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Secreted by macrophages
Major chemotactic factor for neutrophils |
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IL-12
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Secreted by macrophages and B cells
Induces differentiation of T cells into TH1 cells Activates NK cells |
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TNF-a
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Secreted by macrophages
Activates endothelium Mediates septic shock Leukocyte recruitment, vascular leak Cachexia, acute phase proteins |
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IL-3
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Secreted by all T cells
Supports growth and differentiation of bone marrow stem cells |
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IL-2
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Secreted by TH1 cells
Stimulates growth of CD8 and CD4 T cells |
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IFN-g
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Secreted by TH1 cells
Activates macrophages and TH1 cells Suppresses TH2 cells Antiviral and antitumor properties Increase MHC expression |
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IL-4
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Secreted by TH2 cells
Induces differentiation into TH2 cells Promotes growth of B cells Enhances class switching to IgE and IgG |
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IL-5
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Secreted by TH2 cells
Promotes differentiation of B cells Enhances class switching to to IgA Stimulates growth and differentiation of eosinophils |
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IL-10
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Secreted by TH2 and regulatory Tcells
Modulates inflammatory response Inhibits actions of TH1 Activates TH2 |
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CD19, 20, 21
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B cell
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CD14
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Macrophage
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CD16, 56
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NK cell
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ANA
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SLE, nonspecific
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Anti-dsDNA, anti-Smith
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SLE
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Anti-histone
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Drug-induced lupus
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Anti-IgG
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Rheumatoid arthritis
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Anticentromere
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Scleroderma
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Anti-topoisomerase
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Scleroderma (anti-Scl-70)
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Anti-mitochondrial
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Primary biliary cirrhosis
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Anti-gliadin
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Celiac disease
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Anti-BM
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Goodpasture's syndrome
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Anti-desmoglein
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Pemphigus vulgaris
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Antimicrosomal, Antithyroglobulin
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Hashimoto's thyroiditis
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Anti-Jo-1
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Polymyositis, dermatomyositis
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Anti-SS-A, Anti-SS-B
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Sjogren's syndrome
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Anti-U1 RNP
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Mixed connective tissue disease
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Anti-smooth muscle
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Autoimmune hepatitis
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Anti-glutamate decarboxylase
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DMI
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c-ANCA
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Wegner's granulomatosis
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p-ANCA
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Vasculitis
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AL
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Ig light chains - multiple myeloma
Primary/Bence Jones Amyloidosis |
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AA
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Serum amyloid-associated protein (SAA) - chronic inflammatory disease
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Transthyretin
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Senile cadiac
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Amylin
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Derived from insulin, DMII
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A-CAL
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Calcitionin
Medullary carcinoma of the thyroid |
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B-amyloid
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Amyloid precursor protein (APP)
Alzheimer's and Trisomy 21 |
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B2 microglobulin
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MHC I
Dialysis associated |
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abl
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CML
Tyrosine Kinase |
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c-myc
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Burkitt's lymphoma
Transcription factor |
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bcl-2
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Follicular and undifferentiated lymphomas
Anti-apoptotic molecule |
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erb-B2
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Breast, ovarian, gastric carcinomas
Tyrosine kinase |
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ras
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Colon carcinoma
GTPase |
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L-myc
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Lung caner
Transcription factor |
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N-myc
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Neuroblastoma
Transcription factor |
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ret
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Multiple endocrine neoplasia (MEN)
Tyrosine kinase |
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c-kit
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Gastrointestinal stromal tumor (GIST)
Cytokine receptor |
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Rb
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Retinoblastoma, osteosarcoma
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p53
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Most cancers, Li-Fraumeni syndrome
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BRCA1
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Breast and ovarian cancer
DNA repair |
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BRCA2
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Breast cancer (men)
DNA repair |
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p16
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Melanoma
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APC
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Colorectal cancer
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WT1
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Wilm's tumor
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NF1
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Neurofibromatosis 1
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NF2
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Neurofibromatosis 2
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DPC
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Pancreatic cancer
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DCC
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Colon cancer
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CA-125
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Ovarian cancer
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S-100
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Melamnoma
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Chromogranin
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Neuorendocrine cells
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Bombesin
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Neuroblastoma, lung and gastric cancer
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TRAP
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Hairy cell leukemia
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CA-19-9
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Pancreatic adenocarcinoma
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Aflatoxins
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Hepatocellular carcinoma
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Vinyl chloride
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Angiosarcoma
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Cigarette smoke
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Oropharyngeal, kidney/bladder, pancreas, cervix
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Asbestos
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Lung
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Arsenic
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Skin, liver
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Naphthalene
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Bladder
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t(9;22)
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Philadelphia chromosom
bcr-abl hybrid CML |
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t(8;14)
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c-myc activation
Burkitt's lymphoma |
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t(14;18)
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bcl-2 activation
Follicular lymphoma |
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t(15;17)
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Retinoic acid receptor interuption
AML |
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t(11;22)
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Ewing's sarcoma
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t(11;14)
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Cyclin D overexpression
Mantle cell lymphoma |
