Blood Bank Quiz

Front 1

The only system known that is not manufactured by the RBCs as integral parts of their membrane.

Back 1

Lewis

Front 2

The Lewis antigens are manufactured by ______, secreted into the body fluids, and are absorbed (stuck) onto the RBC membrane

Back 2

Tissue Cells

Front 3

Lewis antigens are not ____ to the RBC membrane produced during the cell development.
Antigens are produced by tissue cells and are absorpted onto the RBCs.

Back 3

Intrinsic

Front 4

. A person’s Lewis phenotype is NOT determined SOLELY by genes at the Lele locus.
_____ and ___loci are involved with the Lele locus

Back 4

Hh and Sese

Front 5

The amount of Lewis antigen expression on the RBC varies according to the cell’s

Back 5

ABO phenotype

Front 6

The Lewis gene (Le) on the short arm of chromosome __ codes for ά-4-L-fucosyltransferase

Back 6

19

Front 7

___% of the white population possesses the Le gene

Back 7

90%

Front 8

Both the Le and Se genes are needed for the expression of the ___ substance.

Back 8

Lewis B

Front 9

Le(a+b-) Phenotype

Back 9

NonSecretors

Front 10

, all Le(a+b-) individuals are ______ of ABH substances.

Back 10

Nonsecretors

Front 11

Le(a-b+) Phenotype

Back 11

Secretors

Front 12

ABO, Hh, and Lewis genes are all involved in the formation of the ___ antigen

Back 12

Lewis B

Front 13

The Le(a-b+) phenotype results from an interaction of ____ and ___ genes

Back 13

Lele and Sese

Front 14

In the Le(a-b+) both Lea and Leb soluble antigens are present in the secretions and plasma but only ___ appears on the RBC surface

Back 14

Lewis B

Front 15

Le(a-b-) Phenotype

Back 15

Secretors or Nonsecretors

Front 16

Secretor (SeSe or Sese) + Le
RBC phenotype: Le(a-b+)
Substances in secretions

Back 16

H, Le A, Le B

Front 17

Secretor (Sese or Sese) + lele
RBC phenotype: Le(a-b-)
Substances in secretions:

Back 17

H

Front 18

Non-secretor (sese) + Le
RBC phenotype: Le(a+b-)
Substances in secretions

Back 18

Le A

Front 19

Non-secretor (sese) + lele
RBC phenotype: Le(a-b-)
Substances in Secretions:

Back 19

None

Front 20

When the genotypes Le and sese are inherited, Lewis antigens are not detectable on the cord RBCs but these infants do secrete Le_ substances in their saliva.

Back 20

Le A

Front 21

Newborns ALWAYS type as Le____ by standard agglutination.

Back 21

(a-b-)

Front 22

Pregnant women can demonstrate a _____ in the expression of the Lewis antigens during gestation

Back 22

decrease

Front 23

Lea antigen is present in about __% of the population

Back 23

22%

Front 24

Leb antigen is present in about __ % of the population

Back 24

72%

Front 25

Persons who are Le(a-b+) can’t make an anti-Lea antibody because:
Lea is present in their ___ and ___.
Lea structure is contained within the Leb antigen

Back 25

plasma and saliva

Front 26

Lewis antibodies are usually not considered a threat to the neonate during gestation because:

Back 26

IgM, Cant cross placenta, phenotype as Le(a-b-)

Front 27

Most common encountered antibody of the Lewis system:
Present in 20% of the individuals with the Le(a-b-) phenotype

Back 27

Anti-Le a

Front 28

can be formed by massive transfusion of Lewis positive antigens

Back 28

IgG anit-Le a

Front 29

_____ system is associated with factors causing certain diseases, such as peptic ulcers, ischemic heart disease, cancer, and kidney transplant rejection

Back 29

Lewis

Front 30

expresses Lewis antigens as a component in its lipoplysaccharide structure.
The expression of the Lea and Leb is associated with a more severe disease state.

Back 30

Helicobacter Pylori

Front 31

The lack of Le and Se genes in the Le(a-b-) phenotype is associated with an increased risk for

Back 31

Coronary Heart Disease

Front 32

The presence of Lewis antibodies in Lewis-negative individuals is associated with a higher _______ than in Lewis-positive people.

Back 32

renal allograft rejection

Front 33

Based upon recent biochemical and molecular genetics studies, the P, Pk, and LKE antigens are now being considered to the _____ collection of antigens, leaving only P1 in the P blood group system.

Back 33

globoside

Front 34

The P1 antigen is present on the RBCs of __% of the population

Back 34

80%

Front 35

Approximately __% of the population lack the P1 antigen and are designated as P2
(Similar to the 80% A1 and 20% A2 in the ABO System)

Back 35

20%

Front 36

P1 individuals have two antigens on their RBCs:

Back 36

P and P1

Front 37

individuals have only the P antigen and can produce an anti-P1 antibody

Back 37

P2

Front 38

Deteriorates Rapidly On Storage

Back 38

P1 Antigen

Front 39

Weak, cold-reactive saline agglutinin optimally reactive at 4°C and not usually seen in routine testing.

Back 39

Anti-P1

Front 40

Anti-P1 that reacts only at temperatures below 37°C are considered

Back 40

Clinically Significant

Front 41

class auto anti-P has been associated with habitual early abortion

Back 41

IgG

Front 42

PCH is associated with what antibody?

Back 42

Donath Landsteiner anitbody

Front 43

IgG auto-anti-P antibody
Complement dependent
Biphasic Hemolysin:

Back 43

donath Landsteiner antibody

Front 44

presents itself most commonly as an acute, transient, hemolytic disorder often occurring after a viral infection and is particularly more common in young children

Back 44

PCH

Front 45

In older patients, it manifests itself as a chronic disease.

It has been associated with syphilis.

Back 45

PCH