Variation in intestinal component of serum alkaline phosphatase due diet in different ABO group population of Khyber Pakhtunkhwa
Corresponding author: Muhammad Jaseem Khan, M. Phil.
E-mail: Jaseem.ipms@kmu.edu.pk, Ph: +923315296282
Authors Contribution:
1Muhammad Jaseem Khancarried out the research work, statistical analysis and writing of manuscript.
2Basir Ahmed (BS MLT) collected and analyzed samples as co-researcher
Ph: +923329378621
3Dr. Saeed Ahmed(PhD) reviewed and approved the final manuscript,
Ph: +923009368196
4Momin Khan, design and supervised the research work, +923478903912
1, 2 & 4: Khyber Medical University Peshawar
3: Serhad University of Sciences and Technology, Peshawar
ABSTRACT
Introduction:Intestinal alkaline phosphatase …show more content…
There was no study carried out before in Pakistani population to check that diet can influence the value of alkaline phosphatase. It is important to know because random ALP advises routinely by physician for diagnosis of obstructive jaundice, bone diseases and so many other disorders.
In present study, asignificance difference (p = 0.001) was found in fasting and random values of ALP. Mean difference in fasting and random ALP value is 20.5% while about 15.2% individuals exceed ALP value from the upper normal limit after taking breakfast. High fat diet increased the ALP in O and B blood group secretors after 3 to 6 hours of taking the fatty meal9. The same study was conducted by Matsushita et al. in which low and high calorie fat meal was compared in secretors blood groups. ALP activity in B secretors is 8.8% higher due to high calorie meal than low calorie meal and 5.2% higher in O secretors but in our study, 22.7% increase was seen in A blood group, 19.7% in B, 25% in AB and 22.6% in O blood group after taking breakfast. This increase was equally regardless both genders. Because this increase ranges from 19.7% to 25% which can greatly affect the diagnosis important of ALP. As NIAP dependent on fatty meal and markedly increased after fatty meal so it issuggested that, as a rule, for ALP activity analysis blood …show more content…
Since blood groups are not alterable in healthy people, they have assumed considerable importance in forensic medicine in the analysis of genetic variability, human genetics & anthropology [1]. The property of individuals to secrete these antigenic substances in body fluids such as saliva, gastric juice, seminal fluid etc. is termed as the secretor status. A pair of alleles Se and se determines the secretor status. The knowledge of secretor status can be applied for tissue transplantation among other applications [2]. Various studies have been done trying to co-relate the ABO blood groups with diseases eg. Peptic ulcer, duodenal ulcer, pernicious anemia, gallstones, carcinoma of the stomach and Ischemic Heart Disease (IHD)
Corresponding author: Muhammad Jaseem Khan, M. Phil.
E-mail: Jaseem.ipms@kmu.edu.pk, Ph: +923315296282
Authors Contribution:
1Muhammad Jaseem Khancarried out the research work, statistical analysis and writing of manuscript.
2Basir Ahmed (BS MLT) collected and analyzed samples as co-researcher
Ph: +923329378621
3Dr. Saeed Ahmed(PhD) reviewed and approved the final manuscript,
Ph: +923009368196
4Momin Khan, design and supervised the research work, +923478903912
1, 2 & 4: Khyber Medical University Peshawar
3: Serhad University of Sciences and Technology, Peshawar
ABSTRACT
Introduction:Intestinal alkaline phosphatase …show more content…
There was no study carried out before in Pakistani population to check that diet can influence the value of alkaline phosphatase. It is important to know because random ALP advises routinely by physician for diagnosis of obstructive jaundice, bone diseases and so many other disorders.
In present study, asignificance difference (p = 0.001) was found in fasting and random values of ALP. Mean difference in fasting and random ALP value is 20.5% while about 15.2% individuals exceed ALP value from the upper normal limit after taking breakfast. High fat diet increased the ALP in O and B blood group secretors after 3 to 6 hours of taking the fatty meal9. The same study was conducted by Matsushita et al. in which low and high calorie fat meal was compared in secretors blood groups. ALP activity in B secretors is 8.8% higher due to high calorie meal than low calorie meal and 5.2% higher in O secretors but in our study, 22.7% increase was seen in A blood group, 19.7% in B, 25% in AB and 22.6% in O blood group after taking breakfast. This increase was equally regardless both genders. Because this increase ranges from 19.7% to 25% which can greatly affect the diagnosis important of ALP. As NIAP dependent on fatty meal and markedly increased after fatty meal so it issuggested that, as a rule, for ALP activity analysis blood …show more content…
Since blood groups are not alterable in healthy people, they have assumed considerable importance in forensic medicine in the analysis of genetic variability, human genetics & anthropology [1]. The property of individuals to secrete these antigenic substances in body fluids such as saliva, gastric juice, seminal fluid etc. is termed as the secretor status. A pair of alleles Se and se determines the secretor status. The knowledge of secretor status can be applied for tissue transplantation among other applications [2]. Various studies have been done trying to co-relate the ABO blood groups with diseases eg. Peptic ulcer, duodenal ulcer, pernicious anemia, gallstones, carcinoma of the stomach and Ischemic Heart Disease (IHD)