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27 Cards in this Set
- Front
- Back
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what are neutrophils produced by |
bone marrow |
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how can neutrophils dying be delayed |
by pathogensl |
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what does neutrophils have on their surface |
have fas and TNFR1- once bound to appropriate ligand it activates FADD AND TRADD which activates caspases |
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why dont you want an inflammatory response |
can cause cytokine storm |
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what neutrophil cytokines are upregulated after stimulation |
IL-6 IL-8 IL-12, TNF-a |
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what neutrophil cytokines are prob inflammatory |
IL-6 IL-8 and TNF-a |
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what neutrophils anti inflammatory cytokines |
resolvin and lipoxin |
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how do neutrophils phagocytose targets |
through prr |
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explain neutrophil recruitment |
roll along walls of post capillary tubules respond to pathogen induced chemotactic signals move out of vascular system and into tissues- stop rolling movement and get firm adhesion to endothelial wall |
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what is the process of passing though the endothelial cell layer called |
extravasation or diapedesis |
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tethering and rolling of neutrophils along blood vessle wall is due to what |
reversible binding of transmembrane glycoprotein adhesion molecules called selectins |
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different lectins are involved in what |
different things |
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name 3 types of selectin |
leukocyte ( l-selectin) endothelial selectin platelet selectin |
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explain leukocyte selectin |
L-selectin binds to fucosylated variant of CD34 |
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expain platelet selectin |
p-selectin released onto endothelial cells and binds to PSGL-1 p-selectin gycoprotein ligand on neutrophil |
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explain endothelial selectin |
e-selectin binds to varous sialyic acid and fucose glycoproteins on neutrophil |
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what happens when neutrophil makes its first binding |
firm adhesion from the cell |
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what is some examples of frim adhesion |
integrins intercellular adhesion molecules (icams) |
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explain integrins |
group of heterodimeric transmembrane glycoprotein that mediate cell-cell cell-extracellular matrix adhesion |
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give examples of integrins |
macrophage antigen 1 (MAC1) lymphocyte associated function antigen 1( LFA1) |
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explain what happens in intracellular adhesion molecules ( icams) |
MAC1 binds icam preferentially on endothelial cells LFA1 binds icams preferentially on endothelial cells |
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where does neutrophil homing to transmigration sites on the endothelium happen |
at tricellular junctions |
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where is pecam1 found |
found on neutrophils and endothelial cells |
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what can PECAM1 do and what can this lead to |
serve as its own ligand to form homodimers, has a junctional location on endothelial cells so can serve as a homing device lead to extravastation |
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how do neutrophils move through subendothelial matrix |
very little is known proteases produces CD18 and VLA Which bind to fibronectin need to be done in a way were the correct ligands move through the tissues |
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what can TNF-a and IL-1 do in adhesion |
upregulate adhesion molecules but not chemotactic themselves |
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what are the 5 neutrophil receptors for chemoattractsnts |
PAF, C5a, leukotriene B4, formyl, methionyl, leucyl- phenylalanine chemokines |
