Block 3 Midblock Other Viral Infections Hermel

Front 1

EBV and CMV overview

Back 1

members of herpesviridae family, cause persistent infections by latently infecting different cell types, enveloped DNA viruses

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disease caused by EBV

Back 2

infectious mono

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highest incidence of EBV

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15-24 yo esp in college and military

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symptoms of EBV

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fever up to 104, night sweats, malaise, pharyngitis, tonsillitis, lymphadenopathy, splenatomegaly

Front 5

EBV pathogenesis

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Viral LMP-1 and LMP-2 proteins drive naïve B cells to proliferate and become resting memory cells which is where latent virus lies

Front 6

Lab findings of EBV

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polyclonal B cell activator, elevated serum Ig, presence of heterophile antibodies, IgM antibodies to viral capsid antigens (VCA)

Front 7

Treatment of EBV

Back 7

supportive treatment only

Front 8

heterophile antibodies

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anti sheep RBC Abs yielding a positive Monospot test

Front 9

Acute serological profiles for EBV infections

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positive heterophile antibodies, VCA-IgM, IgG, EA (early antigens)

Front 10

EBV differentail

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CMV infection, group A streptococcal infections esp strep throat

Front 11

what happens to mono pts given ampicillin or amoxicillin

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they develop a rash

Front 12

Carcinogenesis of EBV

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burkitts lymphoma, nasopharyngeal carcinoma, B cell lymphoma in immunocompromised pts

Front 13

what does LMP1 do

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induces cellular transformation and promotes cell motility and invasio. Engages multiple signaling cascades

Front 14

EBV nuclear antigin 1

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expressed in all EBV associated malignancies and also contributes to cell growth and transformation (essential for viral genome mx. ) aka EBNA 1

Front 15

CMV preferrentiall infects

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monocytes

Front 16

CMV mainly causes disease in

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immunocompromised pts

Front 17

CMV infection differentials

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EBV infection

Front 18

cmv pathogenesis

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latent infection, inhibition of host cellular immune responses, transplacental passage to fetus

Front 19

cmv differs from ebv mono by

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no heterophil antibodies, cervical lymphadenitis and pharyngitis are rare. Age of onset is 28, milder liver involvement

Front 20

CMV disease in AIDS pts

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CMV retinits

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CMV disease in ca/tpx pts

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interstitial pneumonitis

Front 22

most common viral cause of birth defects

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CMV, causes stillbirths

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treatment of life threatening CMV infections

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Ganciclovir Valganciclovir Cifofovir Foscarnet

Front 24

ganciclovir and valganciclovir require and cause

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require activation of viral and host kinases, inhibit DNA polymerase +/- chain termination

Front 25

what do CMV infected cells look like

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haloed nuclear inclusion (owls eye)

Front 26

hemorrhagic fever viruses are all

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enveloped RNA viruses

Front 27

hemoragic fever viruses characterized by

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a variety of cutaneous and systemic manifestations, all due to vascular instability and bleeding

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symptoms of hemorrhagic fevers

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fever, myalgia, headache, prostration, hemorrhage, conjunctival infection, coagulopathy, capillary leak, hypotension, shock, death

Front 29

arthropod vectors

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arboviruses

Front 30

mosquitos carry

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flaviviruses (dengue fever)

Front 31

rodent contact

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arena viruses can be through bites or inhalation of dried roted shit or urnie

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HF pathogenesis

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toxic effects on endothelial cells, interference with interferon a and b fx

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key event in hf pathogenesis

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damage to vascular endothelium (capillary toxicity(

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lab findings of HF

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leukopenia is suggestive, thrombocytopenia is typical, AST SGOT typically elevated and has prognostic value

Front 35

arenaviruses

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lassa, junin

Front 36

arenaviruses spread by

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inhallation of dried rodent shit or urnie

Front 37

lassa fever

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endemic to west africa, mortality highest in preggos, can be treated with Ribavirin

Front 38

Tacaribe complex hemorrhagic fever

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Junin

Front 39

flaviviruses

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dengue, mosquito borne illness, has 4 serotypes

Front 40

serotypes of Dengue

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Den 1-4

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Dengue

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sever febrile disease rapid onset of high fever, headache, retro orbital pain, diffuse and severe body pain (muscle and bone), weakness and maculopapular rash

Front 42

what are common findings with dengue fever

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leukopenia and thromboctyopenia

Front 43

Dengue fever immunity

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lifelong but serotype specific

Front 44

filoviruses

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ebola, marburg

Front 45

treatment of filoviruses

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high mortality rates, supportive care only, barrier precautions necessary