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365 Cards in this Set

  • Front
  • Back

What are lymph nodes?

Oval/bean-shaped structures located along lymphatic vessels

What is the function of lymph nodes?

House immune cells

What are inguinal lymph nodes?

Lymph nodes located in groin area

What are axillary lymph nodes?

Lymph nodes located in the armpit area

What are cervical lymph nodes?

Lymph nodes located in the neck area

What is the fibrous capsule (of the lymph node)?

Dense CT surrounding & extending into lymph nodes

What are trabeculae (of lymph node)?

Partitions that divide lymph nodes into compartments

What are the lymphatic nodules?

Groups of B cells located in outer cortex


[look like "meatballs" in the lymph nodes]

What are the medullary cords (of lymph node)?

Lymphatic tissue primarily consisting of macrophages

What are the germinal centers (of lymph node)?

Center of lymphatic nodules where B cells proliferate, but ONLY in response to antigen

What is the function of afferent lymphatic vessles?

Carry lymph INTO lymph nodes

What is the function of efferent lymphatic vessels?

Carry lymph AWAY from lymph nodes

What are lymphatic sinuses?

Passageways for lymph to flow

Trace the pathway of lymph through nodal sinuses

Subcapular sinus -->


Trabecular sinus -->


Medullary sinus -->


Efferent vessels

Where is the subcapsular sinus located?

Passageway under fibrous capsule

Where is the trabecular sinus located?

Passageway near trabeculae of lymph nodes

Where is the medullary sinus located?

Passageway near medulla of lymph nodes

What is the function of lymph ducts?

Return lymph to blood

Where is the cisterna chyli located?

Beginning of thoracic duct

What differentiates the cisterna chyli from other lymph vessels?

It's enlarged

What is the function of the cisterna chyli?

Drains lymphatic GI to transport lipids

Approximately how long is the thoracic duct?

18"

What is the function of the thoracic duct?

Drains lower & upper L of body & lower R of body of lymph

Where is the thoracic duct located?

Entrance into L subclavian vein & juggular

Approximately how long is the right lymphatic duct?

3"

What is the function of the right lymphatic duct?

Drains R upper 1/2 of body of lymph

Where is the right lymphatic duct located?

Entrance into R subclavian vein & juggular

What is the function of the lymph capillaries?

Drains interstitial fluid from systemic capillaries

What are the lacteals?

Lymphatic capillaries of small intestine

What is the function of the lacteals?

Transport lipids & lipid-soluble vitamins (D, E, A, K)

What is the mammary plexus?

Nodes & vessels of the mammary area

What is the largest mass of lymphatic tissue?

Spleen

What is the function of the spleen?

Filters blood

What is red pulp?

Blood-filled sinuses of the spleen

What is white pulp?

Lymphatic tissue around a central artery

What is white pulp primarily composed of?

-Lymphocytes
-Macrophages

What is the thymus?

Bi-lobed organ b/w sternum & aorta where T cells mature (i.e., acquire immunocompetency)

What are the lobules of the thymus?

Compartments of the thymus separated by trabeculae

What does M.A.L.T. stand for?

Mucosa Associated Lymphatic Tissue

What is M.A.L.T.?

Lymphatic tissue of the tonsils and all tracts that open to the outside of body

What are Peyer's patches (in ileum)?

Lymphatic nodules in lamina propria of mucous membrane

What do the tonsils consist of?

M.A.L.T.

How many tonsils are there?

-2 palatine


-2 lingual


-1 pharyngeal

Where are the palatine tonsils located?

Posterior region of oral cavity

Where is the pharyngeal tonsil located?

Embedded in posterior nasopharynx

Where are the lingual tonsils located?

At base of tongue where the tongue attaches to floor

What are the 5 types of leukocytes?

-Neutrophils


-Monocytes


-Eosinophils


-Basophils


-Lymphocytes

What types of leukocytes are involved in phagocytosis?

-Neutrophils


-Monocytes (after transforming into fixed/wandering macrophages)

What is the general function of lymphocytes?

Protection against disease, injury, & foreign invaders

What is the function of basophils?

Liberate heparin (anticoagulant), histamine (vasodialator), & sepatonin

What is the function of lymphocytes?

Mediate immune response (antigen/antibody reactions)

What are the types of lymphocytes?

-B cells


-T cells


-Natural killer (NK) cells

What is the function of B cells?

Develop into plasma cells that secrete antibodies

What is the function of T cells?

Attack invading viruses, cancer cells, & transplant cells

What is the function of NK cells?

Attack a wide variety of infectious microbes & certain spontaneously arising tumor cells

What is lymph?

Clear or milky white fluid found in lymphatic vessels

What is chyle?

Lymph draining from sm. intestine that is milky white due to presence of dietary lipids

Trace the flow of lymph?

Interstitial fluid -->


Afferent lymphatic vessels -->


Regional lymph nodes -->


Efferent lymphatic vessels -->


R/L lymphatic duct -->


Venous blood (via subclavian veins)

What are means by which lymph is moved?

-Skeletal muscle pump


-Respiratory pump


-Pressure in interstitial space


-One-way valves

What is the immune system's 1st line of defense?

-Skin


-Mucous membranes

What is the immune system's 2nd line of defense?

-Antimicrobial substances (interferons, complement systems, iron-binding proteins, antimicrobial protein)


-NK cells


-Phagocytes

What are internal lines of defense?

-NK cells


-Phagocytes


-Inflammation


-Fever

What structures release interferon?

-Lymphocytes


-Macrophages


-Fibroblasts

What is the function of interferon?

Used to prevent viral replication

What is interleuken-I?

Regulatory & inflammatory cytokines

What is interleuken-II?

Cytokine signalling molecule that regulates WBCs

Characteristics of inflammation?

-Redness


-Heat


-Swelling


-Pain

What is inflammation?

Body's immediate response to injury/infection involving influx of plasma & immune cells to localized area

What are the functions of inflammation?

-Dispose of microbes/foreign material


-Dilute toxins


-Prepare for healing

Stages of inflammation?

1) Vasodilation


2) Emigration


-Pus


3) Tissue repair


-Depends on tissue damaged

What is the function of prostaglandins?

May stimulate the emigration of phagocytes through capillary walls

What are the functions of leukotriene?

-Causes increased permeability


-Functions in adherence of phagocytes to pathogens


-Chemotactic agent that attracts phagocytes

What is chemotaxis?

Movement of phagocytes to site of damage

What is pus?

Accumulation of dead phagocytes & damaged tissue

What is the nasal cavity?

Space w/in internal nose

What are the functions of the nasal cavity?

Warms, humidifies, and cleans air

What are the external nares?

Openings in the nasal cavity (nostrils)

What is the vestibule (of nasal cavity)?

Anterior portion of nasal cavity (just inside external nares) containing:


-Sweat glands


-Sebaceous glands


-Hair

What is the nasal septum?

Partition between 2 nasal passages

What forms the nasal septum?

--Vomer


--Perpendicular plate (of ethmoid bone)

What are the functions of the nasal concha & meatuses?

--Increase surface area in internal nose


--Disrupt air flow

What are the functions of the internal nares?

Serve as filter, keeping particles from making it into trachea & lungs

What are the functions of the paranasal sinuses?

--Decrease weight of skull


--Resonate voice


--Buffer against blow to face


--Prevent rapid temp. changes


--Humidify & heat inhaled air

What is the function of the nasolacrimal ducts?

Transmit tears from lacrimal duct to inferior meatus in nasal cavity

What is the olfactory epithelium?

Specialized epithelial tissue involved in smell (neurons, support cells, & mucus)

What is the pharynx?

the "throat," connecting nasal & oral cavities to larynx

What is the function of the Eustachian tubes?

Equalize pressure & drain middle ear

What do the Eustachian tubes connect?

Middle ear to pharynx

What is another name for the adenoids?

Pharyngeal tonsil

What do the adenoids consist of?

Mucosa-Associated Lymphatic Tissue (M.A.L.T.)

What is the function of the soft palate?

Close off nasal passages & airways during swallowing & speech

What are the functions of the uvula?

--Prevents food from entering trachea during swallowing


--Speech (in some cultures)

What is the oropharynx?

Common passageway for air & food/drink

What is the fauces?

Cavity @ back of mouth leading to pharynx

What are the palatine tonsils?

Visible tonsils on L & R sides

What is the function of the palatine tonsils?

Help filter inspired air

Where are lingual tonsils located?

Posterior base of tongue

What are the divisions of the pharynx?

--Nasopharynx


--Oropharynx


--Laryngopharynx

What is the larynx?

Voice box;


encloses vocal cords

What is the thyroid cartilage?

Largest, anterior laryngeal cartilage

What is the function of thyroid cartilage?

Protect vocal cords

What is the Adam's apple called?

The laryngeal prominence

What is the laryngeal prominence?

The bump @ thyroid cartilage where 2 plates meet

What is the special feature of the cricoid cartilage?

Only completely fused cartilage

What is the function of the cricoid cartchilage?

Attachment for muscles & ligaments

What is the function of the epiglottis?

Covers glottis when swallowing

What is the function of the arytenoid cartilages?

Adjust the tension of the true vocal cords

What is the cuneiform cartilage?

Club-shaped elastic cartilages anterior to the corniculate cartilages

What is the function of the cuneiform cartilage?

Support vocal folds & lateral aspects of epiglottis

What is the corniculate cartilage?

Horn-shaped pieces of elastic cartilage located at apex of ea. artenoid cartilage

What is the function of the corniculate cartilage?

Supports epiglottis

What is a mucous membrane?

Membrane that lines a body cavity that opens to the exterior


(AKA - mucosa)

What is another name for the ventricular folds?

False vocal cords

What are the functions of the ventricular folds?

--Close off to increase thoracic pressure


--Protection from choking

What is the vestibule (of the larynx)?

Space underneath epiglottis laryngopharynx

What are the aryepiglottic folds?

Sides of epiglottis

What is the ventricle (of the larynx)?

A lateral expansion of the middle portion of the laryngeal cavity

What are the true vocal cords?

Pair of folds in inferior portion of mucous membrane of larynx

What is the function of true vocal cords?

Vibrate to produce sound

What is the glottis?

Opening @ upper part of larynx between vocal cords

What is the trachea?

Tubular passageway for air

What are the dimensions of the trachea?

12 cm long
25 cm diameter

What is the carina?

Internal ridge that divides R & L primary bronchi

What reflex is located at the carina?

The cough reflex

What type of tissue does the trachealis muscle consist of?

Smooth muscle tissue

What is the function of the bronchial tree?

Conducts air breathed in through nasal cavity down to alveoli

What is the function of the primary bronchii?

Conducts air into/out of ea. lung

What are the secondary bronchii?

Airway that conducts air into a specific lobe of lung

What are the lobes of the R lung?

-Superior


-Middle


-Inferior

What are the lobes of the L lung?

-Superior


-Inferior

What is the function of the tertiary bronchii?

Conduct air to/from bronchiopulmonary segment

What are bronchioles?

Air conducting ducts that supply each pulmonary lobe

What tissue do bronchioles consist of?

Cilliated simple columnar tissue

What are the terminal bronchioles?

Smallest air conducting ducts that supply pulmonary acini

What tissue do terminal bronchioles consist of?

Non-cilliated simple cuboidal epithelial tissue

What are respiratory bronchioles?

Transitional zone concerned with air conduction & gas exchange b/w air & blood

What tissue do respiratory bronchioles consist of?

Simple cuboidal epitheleal tissue to simple squamous epithelial tissue

What are alveolar ducts?

Branch of respiratory bronchiole around which alveoli & alveolar sacs are arranged

What are alveolar sacs?

2 or more alveoli sharing a common opening

What are alveoli?

Cup-shaped pouch lined supported by elastic basement membrane

What tissue do alveoli consist of?

Simple squamous epithelium

What is the function of the respiratory membrane?

Gas exchange

What are the lungs?

Main organs of respiration

What is the apex (of the lung)?

Narrow superior portion of lung

What is the base (of the lung)?

Broad inferior portion of lung that fits over the diaphragm

What is the hilus (of the lungs)?

Where bronchi, nerves, pulmonary blood vessels, & lymphatic vessels enter & exit lungs

What is the costal surface (of the lungs)?

Surface of lungs @ the ribs

What is the cardiac notch?

Medial concavity the L lung has to accommodate the heart

What is the mediastinum?

Area of thoracic cavity between plurae of lungs that extends from sternum to vertebral column

What is the function of pulmonary arteries?

Carries oxygen-poor blood from pulmonary trunk to R & L lungs

What is the function of pulmonary veins?

Returns oxygen-rich blood to the heart from the lungs by draining into L atrium

What are pulmonary capillaries?

Gas exchange vessels in lungs

What is the pleura?

Serous membrane that covers lungs & lines wall of thoracic cavity & diaphragm

What is the visceral pleura?

Deep layer of serous membrane that covers the lungs themselves

What is the parietal pleura?

Superficial layer of serous membrane that lines the walls of thoracic cavity

What is the diaphragm?

Dome-shaped skeletal muscle between thoracic cavity & abdominal cavity

What are the muscles used for inhalation?

--Diaphragm


--External intercostals

What are the muscles used for forced expiration?

--Abdominal muscles


--Internal intercostals

What muscles are used for forced inhalation?

--Sternocleidomastoid (SCM)


--Scalenes


--Pectoralis minor

What are carotid bodies?

Clusters of chemoreceptors on/near carotid sinus that respond to changes in blood levels of O2, CO2, & H+

What are aortic bodies?

Clusters of chemoreceptors on/near aortic arch that respond to changes in blood levels of O2, CO2, & H+

What marks the beginning of the respiratory zone?

1st alveolus

What differentiates bronchi from bronchioles?

Bronchi have cartilage

What cells are the basis of antibody mediated immunity?

B lymphocytes (AKA - B cells)

What cells are the basis of cell mediated immunity?

T lymphocytes (AKA - T cells)

List the circulation pathway of lymph (peripheral to central)

1. Interstitial fluid


2. Lymphatic capillaries


3. Afferent lymphatic vessels


4. Lymph nodes


5. Efferent lymphatic vessels


6. Lymphatic trunks


7. Lymphatic ducts


8. Junction of internal jugular & subclavian veins

What are the 2 lymphatic ducts & what parts of the body do they drain?

--Right lymphatic duct (drains upper right quarter of body)


--Thoracic duct (drains all other three quarters of body)

What are the primary lymphatic organs?

--Red bone marrow


--Thymus

What are the secondary lymphatic organs (& tissue)

--Lymph nodes


--Spleen


--Lymphatic nodules

Describe the flow of lymph through lymph nodes

1. Afferent vessels


2. Subcapsular sinus


3. Trabecular sinus


4. Medullary sinus


5. Hilum


6. Efferent vessels

What does the outter cortex of a lymph node contain?

B cells

What does the inner cortex of a lymph node contain?

--T cells


--Dendritic cells

What does the medulla of a lymph node contain?

Macrophages

What is an immunocompetent cell?

A cell capable of mounting an immune response

What are the regional lymph node groups?

--Submandibular
--Cervical
--Mediastinal 
--Axillary 
--Inguinal  

--Submandibular


--Cervical


--Mediastinal


--Axillary


--Inguinal

What is white pulp?

Lymphatic tissue of spleen where lymphocytes & macrophages carry out immune function

What is red pulp?

Blood-filled sinuses of spleen where platelets are stored & old RBCs are destroyed

Where are interferons (INFs) produced?

In virus infected...


--Lymphocytes


--Macrophages


--Fibroblasts

What is the complement system?

Proteins in blood plasma that "complement" or enhance certain immune functions when activated

What are some of the actions of the complement system?

--Cytolysis of microbes


--Phagocytosis promotion


--Inflammation

What are contained in the granules released by NK cells?

Perforin


--or--


Granzymes

How do perforins affect target cells?

Perforates target cell's membrane, causing cytolysis

How do granzymes affect target cells?

Induce target cell to undergo apoptosis

What are the stages of phagocytosis?

1. Chemotaxis


2. Adherence


3. Ingestion


4. Digestion


5. Killing

What are the stages of inflammatory response?

1. Vasodilation & increased blood vessel permeability


2. Emigration of phagocytes


3. Tissue repair

What are the characteristic signs of inflammation & their causes?

--Heat (vasodilation)


--Redness (vasodilation)


--Swelling (vasodilation)


--Pain (injury to neurons, prostaglandins &/or kinins, & increased pressure due to vasodilation)

What is a cytokine?

A substance released by an immune system cell that have an effect on other cells, such as...


--Interferon


--Interleukin


--Growth factors

What is pus?

A mass of dead phagocytes & damaged tissue

What are the functions of Interleukin-I (IL-1)?

--Mediate inflammation


--Induce fever

What is the function of a mast cell?

Release histamine & other substances during inflammatory & allergic responses

What is inflammation?

Non-specific defensive response to tissue damage

What is the function of histamine?

--Cause vasodilation


--Increase permeability of cells

What are the functions of prostaglandins (PGs)?

--Intensify effects of histamine & kinins


--Stimulate emigration of phagocytes thru capillary walls

What properties distinguish innate from adaptive immunity?

--Specificity


--Memory

Types of adaptive immunity?

--Cell-mediated immunity


--Antigen-mediated immunity

What is cell-mediated immunity most effective against?

--Intracellular pathogens


--Some cancer cells


--Foreign tissue transplants

What is antigen-mediated immunity most effective against?

Extracellular pathogens, including...


--Viruses


--Bacteria


--Fungi

What is clonal selection?

The process by which lymphocyte proliferates & differentiates in response to a specific antigen

What is an epitope?

Specific marker on surface of antigen that IDs the antigen as "foreign"

How is the body able to ID epitopes not encountered before?

Genetic recombination

What are the stages of respiration?

--Pulmonary ventilation (@ alveoli)


--External respiration (@ pulmonary capillaries)


--Internal respiration (@ systemic capillaries & body tissues)

What is the function of the conducting zone?

Bring air into lungs

What passageways make up the conducting zone?

--Nose


--Mouth


--Pharynx


--Larynx


--Trachea


--Bronchi


--Bronchioles


--Terminal bronchioles

What is the function of the respiratory zone?

Main site of gas exchange

What are the passageways associated with the respiratory zone?

--Respiratory bronchioles


--Alveolar ducts


--Alveolar sacs


--Alveoli

What is Henry's Law as it relates to partial pressure?

Increasing the partial pressure of a gas "over" a solution will result in more of that gas dissolving into the solution

What is Dalton's Law as it relates to partial pressure?

With regards to a mixture of gases, the pressure of each gas in a mixture is directly proportional to the percentage of that gas in the mixture

What is a pneumothorax?

When pleural cavity fills with air, possibly causing lung to collapse

What is pleural effusion?

Fluid accumulation in the pleural cavity caused by inflammation

What are the components of a pulmonary lobule?

--Elastic connective tissue (CT)


--Branch from a terminal bronchiole


--Respiratory bronchiole


--Alveoli


--Lymphatic vessel


--Arteriole


--Venule

What is the function of elastic CT fibers surrounding lungs?

Allow the lung to expand to take in air & then retract to express air from lungs during passive expiration

What is surfactant?

Fluid that lowers surface tension of alveolar fluid (so alveoli don't collapse in on themselves)

What is emphysema?

When inner walls of air sacs weaken & eventually rupture resulting in 1 lg. airspace instead of many sm. spaces




(Decreased surface area = Less effective respiration)

What is neonatal KDS?

Lack of surfactants produced in preemies resulting in more labored breathing




(Less surfactants = More work required to overcome surface tension)

What is Tidal Volume?

Volume of air in-/expired during normal, quiet breathing




(abt. 500 mL)

What is Inspiratory Reserve Volume (IRV)?

Volume of air inspired during very deep inhalation




(abt. 3100 mL, depending on height & gender)

What is Vital Capacity?

Inspiratory reserve +
Tidal volume +


Expiratory reserve


(abt. 4800 mL)

What is Residual Volume (RV)?

Air still present in lungs after a forced exhalation




(abt. 1200 mL)

What is Total Lung Capacity?

Vital capacity +


Residual capacity

What is Minute Ventilation (MV) & how is it calculated?

Total amt. of air inhaled & exhaled in 1 min.




MV = respiratory rate x tidal volume

What is Alveolar Ventilation Rate (AVR) & how is it calculated?

Volume of air per min. that actually reaches alveoli




AVR = respiratory rate x (tidal volume - dead space)

Neutrophil

What is the function of a neutrophil?

Phagocytosis



Basophil

What is the function of a basophil?

Release chemicals during allergic response or inflammation



Eosinophil

What is the function of eosinophils?

--Break down histamine (via histaminase)


--Fight parasites



Monocyte

What is the function of a monocyte?

Phagocytosis

What cells do macrophages develop from?

Monocytes



Lymphocyte

What are the structures in green?
What are the structures in green?

Lymphatic capillaries


Lymph node

Afferent lymphatic vessel


Efferent lymphatic vessel



Inguinal lymph nodes

Axillary lymph nodes

Cervical lymph nodes



Fibrous capsule



Trabeculae



Lymphtatic nodules (generally)


-or-


Cortical nodules (specifically in lymph nodes)



Medullary cord

Germinal center



Afferent lymphatic vessel



Efferent lymphatic vessel

Medullary sinus



Subcapsular sinus



Trabecular sinus



Medullary sinus



Cisterna chyli



Chyle



Cisterna chyli



Thoracic duct

What is the function of the thoracic duct?

Transport lipids & lipid soluble vitamins (D, E, A, & K) to blood



Right lymphatic duct



Mammary plexus



Spleen



Thymus

Palatine tonsil

M.A.L.T.



Pharyngeal tonsils


-or-


Adenoids

M.A.L.T.

Lingual tonsils

M.A.L.T.



Trabeculae in trabecular sinus



Lymphatic nodule



Germinal center



B cells (in response to antigen)



Spleen



White pulp

Central artery



Red pulp



Trabecular sinus



Subcapsular sinus



Nasal cavity



Vestibule



Nasal septum



Superior nasal concha

Middle nasal concha

Inferior nasal concha

Inferior nasal meatus

Middle nasal meatus

Superior nasal meatus



Internal nares

Internal nares



Frontal sinus



(Opening to) frontal sinus

Sphenoid sinus



(Opening to) sphenoid sinus



(Opening to) ethmoid sinus



(Opening to) maxillary sinus



(Opening of) nasolacrimal duct



Laryngopharynx

Nasopharynx

Oropharynx

Nasopharynx



Eustachian tube



Pharyngeal tonsils


-or-


Adenoids



Soft palate



Uvula



Uvula



Oropharynx



Fauces



Palatine tonsils



Lingual tonsils

Laryngopharynx



Larynx



True vocal cords



Thyroid cartilage



Laryngeal prominence


-or-


Adam's apple

What is this structure?

What is this structure?

Cricoid cartilage

What is this structure?

What is this structure?

Cricoid cartilage

Cricoid cartilage



Epiglottis



Arytenoid cartilage



Arytenoid cartilage



Cuneiform cartilage



Cuneiform cartilage



Corniculate cartilage



Corniculate cartilage



Corniculate cartilage



Ventricular folds


-or-


False vocal cords



Vestibule



Aryepiglottic fold



Aryepiglottic folds



Ventricle



Glottis



Hilus



Cardiac notch (L lung only)



Superior lobes

Inferior lobes



Middle lobe (R lung only)



Oblique fissure



Horizontal fissure (R lung only)



Mediastinum



Trachea



Carina



L primary bronchus



R primary bronchus



R superior secondary bronchus



R middle secondary bronchus



R inferior secondary bronchus



L superior secondary bronchus



L inferior secondary bronchus

Tertiary bronchi



Alveolus
(pl. Alveoli)



Respiratory bronchiole



Alveolar duct



Alveolar sac



Alveolar sac



Respiratory membrane



Pleural cavity

What condition is this?

What condition is this?

Pleural effusion, excessive fluid in the pleural cavity

What condition is this?

What condition is this?

Pneumothorax, air in the pleural cavity

Diaphragm



External intercostal muscles

Internal intercostal muscles



Sternocleidomastoid muscles

Scalene muscles



Chemoreceptors (peripheral)

Carotid bodies



Aortic body



Medulla oblongata



Chemoreceptors (central)



Alveolar duct