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18 Cards in this Set
- Front
- Back
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fibronectin is the high molecular weight protein that connects collagen, fibrin and some proteoglycans
what do you call the transmembrane protein they hang onto |
integrins
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GAGs are generally composed of two things
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a glucoronic (or iduronic) acid
and an amino sugar that can be sulfated or acetylated |
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where does proteoglycan synthesis start
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in the rough ER
linkage of a trisaccharide to serine or threonine residues of the central protein strand activated amino sugars and UDP-glucaronic acids pile are added to make the repeating saccharide units |
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so the three elements of the proteoglycan are
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a protein core with serine or threonine residues
a trisaccharide link of xylose, gal, gal repeating uronic acid and amino sugars |
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whats the last thing that happens to a proteoglycan in synthesis
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sulfation
by PAP phosphoadenosylphosphosulfate |
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a defect in the sulfation of the growing proteoglycans can lead to what kind of diseases
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chondrodystrophies
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what do you call a lot of proteoglycans arranged by link proteins on a central strand of hyaluronate
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proteoglycan aggregate
assembled extracellularly |
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the molecular weight of hyaluronate is in the millions
where is it synthesized |
hyalonurate is synthesized by integral membrane proteins and released into the ECM by ABC transporters
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4 places you're gonna find hyalonuric acid
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the vitreous body of the eye
they synovial fluid of the joints cartilage loose connective tissues |
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heparin is a GAG
where do you find it |
INTRAcellularly
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in what type of cells do you find heparin
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mast cells
lining the arteries, especially in the lungs, liver and skin |
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what's heparin got a lot of
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sulphur
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in the clotting cascade prothrombin is cleaved to thrombin
thrombin cleaves fibrinogen to fibrin to form the clot what is the anticoagulative action of heparin |
heparin facilitates the binding of anti-thrombin to thrombin which leads to the end of blood clotting
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most plasma proteins are glycoproteins, the exception being-
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albumin
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mucins are long proteins with a negatively charged _________
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sialic acid (NANA)
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proteins can be glycosylated two ways
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O-linkages to hydroxyl groups (mainly UDP-sugars and UDP-amino sugars) ie Blood Types
N-linkages to the Nitrogen of Asparagine (only) |
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N-glycosolation occurs where
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in the ER
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what is the scaffold precursor for an oligosaccharide that will be transfered to an Asparagine reside of a growing polypeptide chain
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dolichol pyrophosphate
(dolichol PP) |
